Enhanced sciatic nerve regeneration by poly-L-lactic acid/multi-wall carbon nanotube neural guidance conduit containing Schwann cells and curcumin encapsulated chitosan nanoparticles in rat

Jahromi, Hossein Kargar; Farzin, Ali; Hasanzadeh, Elham; Barough, Somayeh Ebrahimi; Mahmoodi, Narges; Najafabadi, Mohammad Reza H.; Farahani, Morteza Sagharjoghi; Mansoori, Korosh; Shirian, Sadegh; Ai, Jafar

doi:10.1016/j.msec.2019.110564

Cited by 81 publications

(42 citation statements)

References 58 publications

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“…The total fiber number is significantly smaller than in the autologous nerve transplantation group, but the axon diameter has been measured 3.7 µm, which is significantly higher than found for autografts (2.3‐µm; Hadlock et al., 2000). Also, a poly‐l‐lactic acid‐based multiwall carbon nanotube has been seeded both with rat SCs, and curcumin encapsulated chitosan nanoparticles (Jahromi et al., 2020). Bridging a 10 mm sciatic nerve defect in rats with this tube has confirmed a specific SC‐ and curcumin‐induced enhancement of sciatic nerve regeneration.…”

Section: Schwann Cell Therapy For Nerve Regenerationmentioning

confidence: 99%

Adipose tissue stem cells in peripheral nerve regeneration—In vitro and in vivo

Rhode

Beier

Ruhl

2020

J of Neuroscience Research

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Section: Schwann Cell Therapy For Nerve Regenerationmentioning

confidence: 99%

Adipose tissue stem cells in peripheral nerve regeneration—In vitro and in vivo

Rhode

Beier

Ruhl

2020

J of Neuroscience Research

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“…[106]. Polyester has attracted wide attention in various tissue engineering applications due to its good biocompatibility, acceptable biodegradability and thermoplastic processability [107]. Hydrogel scaffolds are limited in mechanical stability and have a potential risk of swelling.…”

Section: Polyestersmentioning

confidence: 99%

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Zhang

2020

Polymers

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Fabrication of nerve conduits for perfectly repairing or replacing damaged peripheral nerve is an urgent demand worldwide, but it is also a formidable clinical challenge. In the last decade, with the rapid development of manufacture technologies, 3D printing and bioprinting have been becoming remarkable stars in the field of neural engineering. In this review, we explore that the biomaterial inks (hydrogels, thermoplastic, and thermoset polyesters and composite) and bioinks have been selected for 3D printing and bioprinting of peripheral nerve conduits. This review covers 3D manufacturing technologies, including extrusion printing, inkjet printing, stereolithography, and bioprinting with inclusion of cells, bioactive molecules, and drugs. Finally, an outlook on the future directions of 3D printing and 4D printing in customizable nerve therapies is presented.

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“…Indeed, in silico experiments suggest that a 0.6 mm wall thickness, with an 80% porosity, can be considered optimal for nerve regeneration (Kokai et al, 2009;Tonda-Turo et al, 2011a;Chiono and Tonda-Turo, 2015). Data obtained from in vitro and in vivo experiments on rat sciatic nerve injury model demonstrated that a wall thickness lower than 0.6 mm or higher than 0.8 mm is suboptimal and leads to controversial results (Rutkowski and Heath, 2002;Stang et al, 2009;Tonda-Turo et al, 2011a;Chiono and Tonda-Turo, 2015;Teuschl et al, 2015;Wang et al, 2017;Jahromi et al, 2020). Nevertheless, further studies are necessary to identify the more adequate thickness, since in literature conflictual in vivo results were published.…”

Section: Biomaterials Characteristics To Be Used As a Nerve Conduitmentioning

confidence: 99%

Natural-Based Biomaterials for Peripheral Nerve Injury Repair

Fornasari

Carta

Gambarotta

et al. 2020

Front. Bioeng. Biotechnol.

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Peripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient's life quality. To repair severe nerve injuries characterized by substance loss and to improve the regeneration outcome at both motor and sensory level, different strategies have been investigated. Although autograft remains the gold standard technique, a growing number of research articles concerning nerve conduit use has been reported in the last years. Nerve conduits aim to overcome autograft disadvantages, but they must satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist, since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potentiality to be used to produce nerve guides. Although they share many characteristics with synthetic biomaterials, natural-based biomaterials should also be preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review reports the strengths and weaknesses of natural-based biomaterials used for manufacturing peripheral nerve conduits, analyzing the interactions between natural-based biomaterials and biological environment. Particular attention was paid to the description of the preclinical outcome of nerve regeneration in injury repaired with the different natural-based conduits.

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Enhanced sciatic nerve regeneration by poly-L-lactic acid/multi-wall carbon nanotube neural guidance conduit containing Schwann cells and curcumin encapsulated chitosan nanoparticles in rat

Cited by 81 publications

References 58 publications

Adipose tissue stem cells in peripheral nerve regeneration—In vitro and in vivo

Adipose tissue stem cells in peripheral nerve regeneration—In vitro and in vivo

3D Printing and Bioprinting Nerve Conduits for Neural Tissue Engineering

Natural-Based Biomaterials for Peripheral Nerve Injury Repair

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