Enhanced Selective Sonosensitizing Efficacy of Ultrasound-Based Anticancer Treatment By Targeted Gold Nanoparticles

Brazzale, Chiara; Canaparo, Roberto; Racca, Luisa; Foglietta, Federica; Durando, Giovanni; Fantozzi, Roberto; Caliceti, Paolo; Salmaso, Stefano; Serpe, Loredana

doi:10.2217/nnm-2016-0293

Cited by 75 publications

(51 citation statements)

References 70 publications

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“…In this case, the NPs acted as sources of nucleation sites, enhancing the inertial cavitation rate in biological environment, and the minor resistance of cancer cells to physical stress is exploited with respect to healthy ones [105]. A recent study [106] on gold NPs, functionalized with PEG and folic acid and activated with ultrasound, showed a promising reduction in cancer cells growth, accompanied by a significant generation of ROS species. Sazgarnia et al [107] also found that the combination of gold NPs, ultrasound and intense pulsed light was a good strategy to further improve the therapeutic effect on tumors.…”

Section: Nps Used In the Sonodynamic Therapymentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

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353

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Nps Used In the Sonodynamic Therapymentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

Self Cite

353

247

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“…Polymer-metal hybrid nanoparticles offer many advantages for diagnosis and therapy, owing to the possibility to endow these materials with multiple functionalities for detecting disease, releasing therapeutic agents or treat the pathology by enhancing externally applied physical stimuli. [1][2][3][4][5][6] However, the clinical applications of nanoparticles in general have been limited by complex and unpredictable pharmacokinetics and targeting. [7][8][9][10] In order to achieve maximal clinical response in vivo any diagnostic or therapeutic agent needs to accumulate at the target tissue and gain access to disease relevant cells and appropriate intracellular compartments.…”

Section: Introductionmentioning

confidence: 99%

Switching of Macromolecular Ligand Display by Thermoresponsive Polymers Mediates Endocytosis of Multiconjugate Nanoparticles

et al. 2018

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Ligand-mediated targeting and internalization of plasma membrane receptors is central to cellular function. These types of receptors have accordingly been investigated as targets to facilitate entry of diagnostic and therapeutic constructs into cells. However, there remains a need to characterize how receptor targeting agents on nanoparticles interact at surface receptors and whether it is possible to control these interactions via exogenous stimuli. Here, we describe the switchable display of the iron-transporting protein, transferrin (Tf), at the surface of thermoresponsive polymer-coated gold nanoparticles and show that internalization of the coated nanoparticles into target cells changes across temperature ranges over which transferrin is expected to be sterically "hidden" by an extended polymer chain and then "revealed" by polymer chain collapse. The switching process is dependent on the numbers of transferrin molecules and thermoresponsive polymer chains attached and whether the assay temperature is above or below the transition temperatures of the responsive polymers at the nanoparticle surfaces. Significantly, however, the control of internalization is critically reliant on overall nanoparticle colloidal stability while the thermoresponsive component of the surface undergoes conformational change. The data show that the cell entry function of complex and large biomolecule ligands can be modulated by polymer-induced accessibility change but that a simple "hide and reveal" mechanism for ligand display following polymer chain collapse is insufficient to account for nanoparticle uptake and subsequent intracellular trafficking.

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“…Considering the various types of materials that can be loaded into the vesicles with the techniques described above, we can assert that NPs can be finely tuned for a wide number of applications through a strict control of physical and chemical parameters [112]. However, when administered into the body, they could face some problems such as opsonization and/or aggregation [113,114].…”

Section: Loading Nanotechnological Modification Into Evsmentioning

confidence: 99%

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Susa

Limongi

Dumontel

et al. 2019

Cancers

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Fast diagnosis and more efficient therapies for cancer surely represent one of the huge tasks for the worldwide researchers’ and clinicians’ community. In the last two decades, our understanding of the biology and molecular pathology of cancer mechanisms, coupled with the continuous development of the material science and technological compounds, have successfully improved nanomedicine applications in oncology. This review argues on nanomedicine application of engineered extracellular vesicles (EVs) in oncology. All the most innovative processes of EVs engineering are discussed together with the related degree of applicability for each one of them in cancer nanomedicines.

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Enhanced Selective Sonosensitizing Efficacy of Ultrasound-Based Anticancer Treatment By Targeted Gold Nanoparticles

Abstract: The combined use of targeting capacity and the ultrasound sensitizing effect, make FA-PEG-GNP promising candidates for the site-specific cancer treatment.

Cited by 75 publications

References 70 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Switching of Macromolecular Ligand Display by Thermoresponsive Polymers Mediates Endocytosis of Multiconjugate Nanoparticles

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

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