2015
DOI: 10.3390/s150510511
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Enhanced Sensitive Love Wave Surface Acoustic Wave Sensor Designed for Immunoassay Formats

Abstract: We report a Love wave surface acoustic wave (LW-SAW) immunosensor designed for the detection of high molecular weight targets in liquid samples, amenable also for low molecular targets in surface competition assays. We implemented a label-free interaction protocol similar to other surface plasmon resonance bioassays having the advantage of requiring reduced time analysis. The fabricated LW-SAW sensor supports the detection of the target in the nanomolar range, and can be ultimately incorporated in portable dev… Show more

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Cited by 32 publications
(20 citation statements)
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“…While both SPR and SAW sensors display theoretically similar sensitivities and detection limits [57], the acoustic sensor is extremely sensitive to temperature variations and care must be taken to properly control the environment around the instrument to keep the temperature stable [12].…”
Section: Methodsmentioning
confidence: 99%
“…While both SPR and SAW sensors display theoretically similar sensitivities and detection limits [57], the acoustic sensor is extremely sensitive to temperature variations and care must be taken to properly control the environment around the instrument to keep the temperature stable [12].…”
Section: Methodsmentioning
confidence: 99%
“…94 From a diagnostic and therapeutic perspective, there are multiple approaches that have been explored. Csete and Hunt, for example have proposed SAW-based biosensors for the early detection of sepsis, with the focus being detecting NO, rather than a biological target, in human breath.…”
Section: Saw-based Sensorsmentioning
confidence: 99%
“…18 The sensitivity of Love-mode and shear-horizontal SAW sensors for molecular targets in water, like protein and DNA, is exceedingly poor, with roughly μM to nM detection limits. 94,195 However, the potential impact of powerful sensors in the bioanalytical domain is significant, and it is in this area where there may be the most opportunity for future developments in SAW devices. We therefore focus on these applications as an area for future research.…”
Section: Perspectives and Directions For The Futurementioning
confidence: 99%
“…The presence of analytes in the medium influences factors of the wave such as its speed and amplitude. The substrate used in a SAW resonator has piezoelectric properties that allow transversal waves to propagate across the surface . When a receptor is adhered to the surface, whether through adsorption or some other kind of reaction, the reception of the wave will be modified due to changes in the wave characteristics .…”
Section: Volatile Biomarker Analysis and Miniaturized Gas Sensing Sysmentioning
confidence: 99%
“…When a receptor is adhered to the surface, whether through adsorption or some other kind of reaction, the reception of the wave will be modified due to changes in the wave characteristics . SAW resonators have been used as an immunoassay format, for the detection of VOCs such as ethanol, acetone, and propanol, and as part of gas chromatography for the early screening of lung cancer…”
Section: Volatile Biomarker Analysis and Miniaturized Gas Sensing Sysmentioning
confidence: 99%