Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Ma, Yun; Zhang, Shujun; Wei, Huanjie; Dong, Yafang; Shen, Liang; Liu, Shujuan; Zhao, Qiang; Liu, Li; Wong, Wai Yeung

doi:10.1039/c8dt00720a

Cited by 19 publications

(8 citation statements)

References 39 publications

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“…41 The cationic quaternary amine functionality in Ir-1-N + and Ir-2-N + was designed to enhance hydrophilicity, cellular uptake and internalization of the PSs, by analogy with other ionic transition metal complexes. [42][43][44] The introduction of a quinolone-triphenylamine derivative as the cyclometalating ligand aims to increase the molar absorption and the singlet oxygen ( 1 O 2 ) generation ability of Ir-2-N + . The corresponding nanoparticles (NPs) Ir-1-N + NPs and Ir-2-N + NPs were prepared by self-assembly process with poloxamer (F127) as surfactant.…”

Section: Introductionmentioning

confidence: 99%

AIE-active Ir(iii) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

et al. 2022

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Section: Introductionmentioning

confidence: 99%

AIE-active Ir(iii) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

et al. 2022

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“…The ttpy ligand was prepared by the condensation reaction between 4‐methylbenzaldehyde and 2‐acetylpyridine according to a previously described method . Phosphorescent complex [Ir(ttpy) 2 ] 3+ was synthesized in two steps: First, iridium(III) chloride salt and 1 equiv.…”

Section: Resultsmentioning

confidence: 54%

Constructing Multi‐Stimuli‐Responsive Luminescent Materials through Outer Sphere Electron Transfer in Ion Pairs

Shen

She

et al. 2019

Advanced Optical Materials

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materials, which can be broadly applied as bioprobes, [2] environmental monitors, [3] optical data storage medium, [4] etc. Generally, the stimuli-responsive luminescent materials are designed based on an inner sphere mechanism for electron transfer, and there are very few examples of such materials based on the outer sphere electron transfer mechanism. In fact, the design and preparation of stimuli-responsive materials based on inner sphere electron transfer mechanism is more difficult because tedious synthetic procedures or complex covalent modifications are often involved (Figure 1a). Supramolecular interactions constructed materials can be considered as ideal candidates to overcome this limit. Ion pairs, particularly those in which one or both of the components are transition metal complexes, have attracted increasing attention recently. [5] The ion-paired materials are of practical importance in the development of organic light-emitting diode, [6] dye-sensitized solar cells, [7] catalysts, [8] chemical sensors, [9] as well as smart electronic devices. [10] Importantly, ionic donor− acceptor interactions may provide an outer sphere mechanism for electron transfer that would enable the construction of stimuli-responsive materials.Ionic phosphorescent iridium(III) complexes have received significant attention due to their appealing photophysical properties, such as high photoluminescence (PL) quantum yields, excellent photostability, significant Stokes shifts, and high sensitivity toward surrounding environments. [11] Among the various ionic iridium(III) complexes, bis-terpyridine iridium(III) complexes are one of the most attractive candidates for the formation of stimuli-responsive ion pairs due to the following features: i) rich photochemistry, complicated excited states, and remarkable photophysical properties are ideal for stimuli-responsive character, [12] ii) high cationic character (charge +3) enables strong electrostatic interactions between donor and acceptor, and iii) very high energy content in the excited states makes them powerful photo-oxidants, [13] ensuring efficient PET processes. Based on these facts, it was hypothesized that the emission intensity of a bis-terpyridine iridium(III) complex would be quenched by the addition of a strong electron donor via a PET process. Subsequently, the consumption Stimuli-responsive luminescent materials are of scientific and technological interest due to their wide range of optoelectronic applications. The utilization of photoinduced electron transfer (PET) reactions is an effective strategy to design various stimuli-responsive luminescent materials. To date, most of these materials are based on the inner sphere electron transfer mechanism, which refers to a redox chemical reaction that proceeds via a covalent bridge. In contrast, the method of using outer sphere electron transfer mechanism is superior to the covalent approach as it does not require tedious synthesis. Ion pairs, which are composed of two oppositely charged components, are ideal for t...

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“…The 1 O 2 production efficiencies of free TCPP molecules and UiO‐66‐TCPP nanoparticles were monitored and compared by UV‐vis spectra using a singlet oxygen indicator (DPBF) . Upon the irradiation of a red‐light LED source, the unchanged absorption peak of DPBF shows its high photostability (Figure S9A).…”

Section: Resultsmentioning

confidence: 99%

Mitochondria‐Targeted Nanoscale MOFs for Improved Photodynamic Therapy

et al. 2019

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Due to the existence of hypoxic microenvironment, the efficacy of photodynamic therapy (PDT) is frequently weakened. As a result, targeted treatment toward oxygenrich mitochondria is considered as a promising cancer therapy. Herein, both triphenylphosphine (TPP) and folic acid (FA) are simultaneously grafted onto nanoscale metal-organic frameworks (NMOFs) to realize dual-targeting delivery of the nanoplatforms into cancer cells and their mitochondria via the proposed phosphorylation modification strategy. A large amount of highly efficient photosensitizer of porphyrinic molecules is integrated into the NMOFs with a uniform particle size of about 65 nm. Thanks to the strong ZrÀ OÀ P bonding, a dense coverage of phosphonate-conjugating targeting molecules on NMOFs is obtained and each surficial unsaturated ZrÀ O cluster is adequately occupied. The resultant dual-targeting NMOFs feature high biostability and biocompatibility, as well as improved cellular uptake and mitochondrial accumulation. The PDT efficacy of these dualtargeting NMOFs is significantly improved with a low IC 50 of 0.74 μM upon 10 min light radiation, which is at least four times higher than that of non-targeting counterparts. This phosphorylation strategy would be hopeful for immobilizing a variety of biogenic groups on NMOFs to make them targetable to various specific organelles and to improve the therapy efficacy on related diseases.

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Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

Cited by 19 publications

References 39 publications

AIE-active Ir(iii) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

AIE-active Ir(iii) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy

Constructing Multi‐Stimuli‐Responsive Luminescent Materials through Outer Sphere Electron Transfer in Ion Pairs

Mitochondria‐Targeted Nanoscale MOFs for Improved Photodynamic Therapy

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