Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders

Priya, Sakshi; Tomar, Yashika; Desai, Vaibhavi Meghraj; Singhvi, Gautam

doi:10.1080/17425247.2023.2190095

Cited by 13 publications

(5 citation statements)

References 99 publications

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“…The conventional drug delivery systems have demonstrated suboptimal efficacy at high doses and are associated with side-effects, which lead to challenges in adherence to therapy. 26 …”

Section: Research On Cb-prp In Wound and Dermatological Disordersmentioning

confidence: 99%

“…The conventional drug delivery systems have demonstrated suboptimal efficacy at high doses and are associated with side-effects, which lead to challenges in adherence to therapy. 26 A previous pilot study treated 12 patients with dystrophic (dermolytic) epidermolysis bullosa (DEB) with CB-PRP gel during 2014-2017. 14 Eight patients showed good-to-very good results, while the treatment was minimally (-/þ to þ) or not effective (-) in two patients and two patients, respectively.…”

Section: Research On Cb-prp In Wound and Dermatological Disordersmentioning

confidence: 99%

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Application of cord blood-derived platelet-rich plasma in the treatment of diseases

Tang,

Li,

Chen

et al. 2024

J Int Med Res

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Platelet-rich plasma (PRP), a blood product containing high concentrations of platelets, has been increasingly used for the treatment of a number of diseases because of its anti-inflammatory and regenerative properties. PRP is generally obtained from the patient’s own peripheral blood when used in clinical applications, but allogeneic PRP extracted from umbilical cord blood has also attracted attention due to its unique advantages. The main purpose of this narrative review was to summarize the research and clinical application of cord blood-derived PRP (CB-PRP) in the treatment of diseases up to April 2024. This review also discusses the differences between CB-PRP and autologous PRP (A-PRP). A thorough search of PubMed® and Clinicaltrials.gov identified 13 articles and four clinical trials. To date, CB-PRP has been primarily studied in the fields of orthopaedics, dermatology, neurology, obstetrics/gynaecology and ophthalmology. This is likely to be because this research is relatively novel. Considering the differences between the characteristics of A-PRP and CB-PRP, it is thought that CB-PRP might hold more promise for broader applications in the future.

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“…The conventional drug delivery systems have demonstrated suboptimal efficacy at high doses and are associated with side-effects, which lead to challenges in adherence to therapy. 26 …”

Section: Research On Cb-prp In Wound and Dermatological Disordersmentioning

confidence: 99%

Section: Research On Cb-prp In Wound and Dermatological Disordersmentioning

confidence: 99%

Application of cord blood-derived platelet-rich plasma in the treatment of diseases

Tang,

Li,

Chen

et al. 2024

J Int Med Res

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“…Mostly, in these disorders, topical delivery of drugs becomes the first line of therapy to achieve localized or targeted therapeutic action. Decrease in systemic side effects, avoidance of first-pass metabolism, ability to provide site-specific delivery, and minimization of dosing frequency by boosting the drug levels at the point of action are some of the noted advantages of topical drug delivery approaches . Also, the large surface area of the skin makes it a potential route for the delivery of pharmaceutical products like local anesthetics, antiseptics, antibacterial, antifungal, and anti-inflammatory agents for localized therapeutic action …”

Section: Introductionmentioning

confidence: 99%

“…Decrease in systemic side effects, avoidance of first-pass metabolism, ability to provide site-specific delivery, and minimization of dosing frequency by boosting the drug levels at the point of action are some of the noted advantages of topical drug delivery approaches. 3 Also, the large surface area of the skin makes it a potential route for the delivery of pharmaceutical products like local anesthetics, antiseptics, antibacterial, antifungal, and anti-inflammatory agents for localized therapeutic action. 4 The skin itself acts as a major challenge for topical drug delivery as it restricts the entry of the therapeutic substances to reach the target site, hence scientists have been looking for ways to make topical drug delivery more effective.…”

Section: Introductionmentioning

confidence: 99%

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Tomar,

Pandit,

Priya

et al. 2023

ACS Omega

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Nanotechnology has yielded nanostructure-based drug delivery approaches, among which nanofibers have been explored and researched for the potential topical delivery of therapeutics. Nanofibers are filaments or thread-like structures in the nanometer size range that are fabricated using various polymers, such as natural or synthetic polymers or their combination. The size or diameter of the nanofibers depends upon the polymers, the techniques of preparation, and the design specification. The four major processing techniques, phase separation, self-assembly, template synthesis, and electrospinning, are most commonly used for the fabrication of nanofibers. Nanofibers have a unique structure that needs a multimethod approach to study their morphology and characterization parameters. They are gaining attention as drug delivery carriers, and the substantially vast surface area of the skin makes it a potentially promising strategy for topical drug products for various skin disorders such as psoriasis, skin cancers, skin wounds, bacterial and fungal infections, etc. However, the large-scale production of nanofibers with desired properties remains challenging, as the widely used electrospinning processes have certain limitations, such as poor yield, use of high voltage, and difficulty in achieving in situ nanofiber deposition on various substrates. This review highlights the insights into fabrication strategies, applications, recent clinical trials, and patents of nanofibers for different skin disorders in detail. Additionally, it discusses case studies of its effective utilization in the treatment of various skin disorders for a better understanding for readers.

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“…[20] TDD is one of the ways to improve the chemical and physical stability of drugs, effectively protecting them from environmental exposure and are effectively applied to sub-surface skin infections, where conventional topical applications may have poor penetration. [21] For instance, compounds like proteins and peptides including polymyxin B (PMB), have been delivered to an infection site using a TDD platform to improve therapeutic efficacy, reduce harmful effects, and facilitate a sustained controlled release. [22] PMB is an antibiotic that is effective in treating Gram-negative bacterial infec-tions.…”

Section: Introductionmentioning

confidence: 99%

Porous silicon microneedle patches for delivery of polymyxin‐based antimicrobials

Tabassum,

Rudd,

Yan

et al. 2023

Nano Select

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There is a global trend of increasing antibiotic resistance to Gram‐negative bacteria and the medical research community is looking for alternative antibiotics. Antibiotics such as polymyxin B (PMB) show excellent efficacy and low resistance rates against Gram‐negative bacteria. The topical administration of PMB, however, has clinical limitations such as minimal residence time, making it difficult for its use to treat skin infections. Here, we present porous silicon microneedle (pSi MN) patches to deliver PMB to the skin. pSi MN patches are fabricated by, first, generating the projections by dry Si etching techniques, followed by an electrochemical etching to create porous layers around the MNs. After loading PMB into the porous layer, the antibacterial activity of pSi MNs is determined by measuring the inhibition zone of Gram‐negative Escherichia coli. Next, PMB is efficiently delivered into the epidermal layer of ex vivo skin models, as confirmed by chemical mapping using matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI). The results demonstrate that pSi MN patches are an efficient and versatile tool for the transdermal delivery of PMB with maintained bioactivity and antimicrobial efficacy, thus expanding the possibilities of current transdermal drug delivery systems.

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Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders

Cited by 13 publications

References 99 publications

Application of cord blood-derived platelet-rich plasma in the treatment of diseases

Application of cord blood-derived platelet-rich plasma in the treatment of diseases

Evolving Trends in Nanofibers for Topical Delivery of Therapeutics in Skin Disorders

Porous silicon microneedle patches for delivery of polymyxin‐based antimicrobials

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