Enhanced Solubility and Antitumor Activity of Annona Squamosa Seed Oil via Nanoparticles Stabilized with TPGS: Preparation and In Vitro and In Vivo Evaluation

Ao, Hui; Lu, Likang; Li, Manzhen; Han, Meihua; Guo, Yifei; Wang, Xiangtao

doi:10.3390/pharmaceutics14061232

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…We think the major reason that 90 mg/kg of OA-ENPs displayed much better tumor targetability than 30 mg/kg of OA-ENPs and 10 mg/kg of OA-ENPs was the result of dosing effect, which was later confirmed by Hui Ao et al. ( 2022 ).…”

Section: Resultsmentioning

confidence: 80%

A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid

Wang

et al. 2022

Drug Delivery

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Oleic acid (OA) is a kind of monounsaturated omega-3 fatty acid that abounds in plants and animals which can induce apoptosis and has broad-spectrum inhibitory activity against a variety of tumor cell lines. However, OA is quite insoluble and thus inconvenient to be efficiently delivered in vivo. In this work, OA was fabricated into nanoparticles to generate OA elastic nanoparticles (OA-ENPs) with a particle size of 185.6 nm and good stability in various physiological media. OA-ENPs alone achieved a high tumor inhibition rate of 60.3% without significant side effect. More surprisingly, the resultant OA-ENPs displayed dose-dependent tumor targetability. Low dose of OA-ENPs (10 mg/kg) mainly distributed in the liver after intravenous injection, while high dose of OA-ENPs mainly distributed in tumor. At the high dose of 90 mg/kg, OA-ENPs accumulation in tumor reached nearly twice as that in the liver. Here we provide a simple but effective way to achieve excellent tumor targetability without the need of any surface modification of nanoparticles.

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Section: Resultsmentioning

confidence: 80%

A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid

Wang

et al. 2022

Drug Delivery

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“…Even within the same species, there may be variations in the FA composition of the seed oil. For instance, research revealed that oleic (37.0%), palmitic (25.1%), and linoleic (10.9%) acids were the predominant FAs in ASSO [74][75][76]. In contrast, 32.0% linoleic and 29.0% oleic contents have been observed [60].…”

Section: Proximate Composition Of Annona Seeds and Seed Oil Extractionmentioning

confidence: 99%

Chemopreventive Potential of Oils Extracted from Seeds of Three Annona Species

Attanayake,

Rupasinghe,

Gamage

et al. 2024

Seeds

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Annona fruit, leaves, seeds, roots, and bark have been conventionally used in many countries for medical treatments as they are considered ideal sources of pharmacologically active compounds, but Annona remains an underutilized fruit in many countries. The fruit of these plants is delicately flavored and is used in industrial products such as ready-to-serve beverages, wine, jellies, jam, and fruit-butter preserve, while the seeds generally go to waste. Annona seed oil contains numerous health-benefiting factors such as vitamins, minerals, bioactive compounds, fatty acids, antioxidants, and phenolic compounds, which are responsible for various biological activities, including antibacterial, antioxidant, and antitumor activities. Cancer is a worldwide major health problem that remains unresolved. Even though the current treatments can manage to reduce tumor growth, there is an urgent need to investigate more efficient but less expensive novel techniques to overcome some of the restrictions in treating tumors. Annona might offer an indispensable choice besides chemotherapy and radiotherapy, especially for terminally ill patients, as the Annona genus contains secondary metabolites in nearly every component of Annona plants. Research has shown that many Annona species contain promising components that could potentially exhibit anticancer activity, but the information available is scarce and inconsistent. Annona muricata (Soursop, “Katuanoda”), Annona squamosa (Sweetsop, “Seenianoda”), and Annona reticulata (Custard apple, “Welianoda”) are three commonly cultivated edible Annona species in Sri Lanka. The main objective of the review was to present an updated comprehensive literature analysis of the putative chemopreventive functions against cancer cell lines/the anticancer effect on cancers, phytochemical properties, and antioxidant properties possessed by the seed oils of three selected common Annona species. Although there are some in vitro and in vivo experimental investigations supporting the benefits of Annona seed oils, clinical investigations are still needed to explore concealed areas, determine the effects on the human body, determine the safest concentration, and determine health-contributing benefits before they are submitted to clinical trials.

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