Enhanced Targeted Delivery of Cyclodextrin‐Based Supermolecules by Core–Shell Nanocapsules for Magnetothermal Chemotherapy

Abstract

In this study, double-emulsion capsules (DECs) capable of concealing drug-incorporated targeted-supermolecules are developed to achieve "on-demand" supermolecule release and enhanced sequential targeting for magneto-chemotherapy. These water-in-oil-in-water DECs less than 200 nm in diameter are synthesized using a single component of PVA (polyvinyl alcohol) polymer and the magnetic nanoparticles, which are capable of encapsulating large quantities of targeted supermolecules composed of palitaxel-incorporated beta-cyclodextrin decorated by hyaluronic acid (HA, a CD44-targeting ligand) in the watery core. The release profiles (slow, sustained and burst release) of the targeted supermolecules can be directly controlled by regulating the high-frequency magnetic field (HFMF) and polymer conformation without sacrificing the targeting ability. Through an intravenous injection, the positive targeting of the supermolecules exhibited a 20-fold increase in tumor accumulation via the passive targeting and delivery of DECs followed by positive targeting of the supermolecules. Moreover, this dual-targeting drug-incorporated supermolecular delivery vehicle at the tumor site combined with magneto-thermal therapy suppressed the cancer growth more efficiently than treatment with either drug or supermolecule alone.

Organic/Inorganic Self‐Assembled Hybrid Nano‐Architectures for Cancer Therapy Applications

“…Hu and co‐workers synthesized a PNC composed of PVA and PEG‐PLGA via a W/O/W emulsion procedure. [ 460 ] The PNC is capable of loading IONPs and Ptx‐conjugated HA in the shell and core region. High‐frequency magnetic field was reported to control the release profile of the loaded β ‐CD‐modified HA with the conjugation of Ptx (Ptx‐CD‐HA).…”

Construction and application of a liver cancer-targeting drug delivery system based on core–shell gold nanocages

“…In this study, a copolymer PM with an appropriate LCST was prepared and employed as the gatekeeper to the gold nanocarrier. Hyaluronan (HA), a negatively charged natural polymer that is nontoxic and biodegradable, [18][19][20] can be degraded by the hyaluronidase (HAase) existing at both the internal and external regions of the tumor cells. 21 In addition, HA has the special affinity for CD44 receptors, which are overexpressed on cancer cells and can promote most of HA-nanoparticles to enter the cancer cells and enable degradation of the bound HA by the HAase in intracellular lysosomes.…”

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

“…9a). 186 Under a high-frequency magnetic field (HFMF), the obtained P-DECs could be damaged to release drugs (Fig. 9b and c).…”