Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge

Integration of Tissue-engineered Cartilage With Host Cartilage: An In Vitro Model

“…This is contrary to other studies showing inhibition of cell death was essential in promoting integration [13,21]. We do not know why our system differs in this respect, but it may be that the extent of contact between the implant and surrounding tissue is critical for the efficacy of integration.…”

Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats

“…Nec-1 has been shown to promise as a cellular protectant in adult rodent models of ischemic brain injury [15] , retinal ischemia-reperfusion injury [16] and myocardial infarction [17]. A previously study showed that Nec-1 could inhibit the chondrocyte cell death on cartilage integrated repair [18]. However, the effect of Nec-1 on GIOP was still ambiguous.…”

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α

“…52 We further anticipate a strategy of chondroprotection where a glucocorticoid, administered from the locale of the injury/repair site in a manner that provides its sustained release at much lower levels than clinical injections, can also impact tissue healing and repair of the engineered graft upon implantation. 41,42 While future plans are aimed at further optimization of the dex microsphere strategy, including the testing of other proinflammatory cytokines such as TNF-a and the evaluation of tissue integrative repair in a cartilage explant ring model, [113][114][115] the efficacy of our approach on cartilage repair will necessarily have to be evaluated in vivo.…”