Enhanced tolerance and antitumor efficacy by docetaxel-loaded albumin nanoparticles

Abstract

Docetaxel is one of the most active chemotherapeutic agents for cancer treatment. The traditional docetaxel injection (TAXOTERE Õ ) is currently formulated in the surfactant polysorbate 80, which has been associated with severe adverse reactions. To avoid the use of polysorbate 80 as well as to reduce the systemic toxicity of docetaxel, in this study, docetaxel-loaded albumin nanoparticles were fabricated by a novel simple self-assembly method. The resulting nanoparticles showed a mean diameter size of 150 nm. After being encapsulated into nanoparticles, docetaxel displayed similar cytotoxicity to traditional injection. Since polysorbate 80 was not involved in nanoparticles, the hemolysis was completely eliminated. The maximal tolerance dose of nanoparticles was also increased, which allowed a higher dose to be safely intravenously injected and produced ideal antitumor effects. The 150 nm diameter also allowed the nanoparticles to accumulate in tumor tissue via the enhanced permeability and retention effect. The passive targeting ability further caused the higher antitumor effects of nanoparticles than that of traditional injection at the same dose (7.5 mg/kg). Therefore, docetaxel-loaded albumin nanoparticles fabricated by our strategy showed higher promise in their safety and effectiveness than the traditional docetaxel injection.

In vitro characterization of pH-sensitive Bletilla Striata polysaccharide copolymer micelles and enhanced tumour suppression in vivo

“…Both DTX‐SA‐BSP copolymer micelles and DTX injection slowed down the tumour growth which may be attributed to DTX. However, the tumour growth inhibition rate of DTX‐SA‐BSP copolymer micelles was higher than that of DTX injection which could be attributed to the DTX‐SA‐BSP copolymer micelles internalization and localization of DTX through cellular uptake.…”

<p>Co-Delivery of Curcumin and Paclitaxel by “Core-Shell” Targeting Amphiphilic Copolymer to Reverse Resistance in the Treatment of Ovarian Cancer</p>

“…The (PEI-SA)HA/PC presented good safety and tolerability. This may still be attributed to the targeting of nanoparticles which reduce the drug adverse reactions 46–48. This does not mean that (PEI-SA) HA/PC is fully non-toxic, but for adverse drug reactions, some other work can be done to avoid it.…”

Pharmacokinetics and in vitro/in vivo antitumor efficacy of aptamer-targeted Ecoflex^&reg; nanoparticles for docetaxel delivery in ovarian cancer

“…For instance, DTX-loaded albumin NPs fabricated by Tang et al 38 by a novel simple self-assembly method could inhibit tumor size to 524.34 mm 3 22 days after injection with DTX at a dose of 7.5 mg/kg, compared to 669.46 mm 3 by free DTX and 1,403 mm 3 in control group. When the injection dose of DTX-albumin NPs was increased to 30 mg/kg, the tumor volume was inhibited to 233 mm 3 .…”