2012
DOI: 10.1124/jpet.112.194464
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Enhanced Vascular Neuronal Nitric-Oxide Synthase-Derived Nitric-Oxide Production Underlies the Pressor Response Caused by PeripheralN-Methyl-d-Aspartate Receptor Activation in Conscious Rats

Abstract: Although the N-methyl-D-aspartate (NMDA) receptor (NMDAR)obligatory unit NMDAR1 is expressed in the vasculature and myocardium, the impact of peripheral NMDAR activation on blood pressure (BP) has received little attention. We demonstrate, for the first time, dose-related pressor responses elicited by systemic NMDA (125, 250, 500, and 1000 g/kg) in conscious rats. The pressor response was peripheral NMDAR-mediated because: 1) it persisted after ganglion blockade (hexamethonium; 5 mg/kg i.v.); 2) it was attenua… Show more

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Cited by 26 publications
(45 citation statements)
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“…ROS level was calculated by relative DCF fluorescence per microgram of protein. Positive and negative controls were used to validate the assay as in our previous studies (McGee and Abdel-Rahman, 2012).…”
Section: Methodsmentioning
confidence: 99%
“…ROS level was calculated by relative DCF fluorescence per microgram of protein. Positive and negative controls were used to validate the assay as in our previous studies (McGee and Abdel-Rahman, 2012).…”
Section: Methodsmentioning
confidence: 99%
“…The optimal NMDA dose/infusion rate that produced an approximately 25-mmHg increase in BP was established in our recent study (McGee & Abdel-Rahman, 2012). The rats were pretreated with water (vehicle) or ethanol (1 g/kg; 10 mL/kg of 13% ethanol diluted in water) 30 min prior to NMDA (180 μg/kg/min) or saline infusion at a rate of 9 μL/min (Harvard compact pump, Model 975) for 30 min.…”
Section: Experimental Groups and Protocolsmentioning
confidence: 99%
“…The selected DL-AP-5 dose (5 mg/kg, i.v. ), which does not cross the blood-brain barrier, caused no change in BP or HR, but virtually abolished the pressor response elicited by NMDA infusion (McGee & Abdel-Rahman, 2012). Groups 1 and 2 received AP-5, 30 min before ethanol (1 g/kg) or water; notably, the effects of ethanol (1 g/kg), compared to water, on BP and HR were investigated under Experiment 1.…”
Section: Experimental Groups and Protocolsmentioning
confidence: 99%
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