Enhanced wound healing activity of Ag–ZnO composite NPs in Wistar Albino rats

Kantipudi, Sravani; Sunkara, Jhansi Rani; Rallabhandi, Muralikrishna; Thonangi, Chandi Vishala; Cholla, Raga Deepthi; Kollu, Pratap; Parvathaneni, Madhu Kiran; Pammi, S.V.N.

doi:10.1049/iet-nbt.2017.0087

Cited by 35 publications

(23 citation statements)

References 22 publications

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“…Nowadays, nanoparticles are primarily the most important aspect of nanotechnology because of their economic and commercial significance. Recent studies have shown the role of metals in life‐threatening diseases [2–4], particularly in the metabolism of glucose and the relation of their decreased levels with the emergence of DM, such as vanadium [5], chromium [6], magnesium [7], and zinc [8].…”

Section: Introductionmentioning

confidence: 99%

Zinc oxide nanoparticles augment CD4, CD8, and GLUT‐4 expression and restrict inflammation response in streptozotocin‐induced diabetic rats

Elassy

El-Dafrawy

El-Azim

et al. 2020

IET nanobiotechnol.

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Section: Introductionmentioning

confidence: 99%

Zinc oxide nanoparticles augment CD4, CD8, and GLUT‐4 expression and restrict inflammation response in streptozotocin‐induced diabetic rats

Elassy

El-Dafrawy

El-Azim

et al. 2020

IET nanobiotechnol.

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“…Furthermore, a variety of single-metal oxide nanoparticulate matrices were doped to enhance their use for wound care. For instance, antimicrobial Ag NPs doped with Zn accelerated wound healing in rats [ 86 ], while the Zn-doping of CuO NPs increased their antimicrobial activity [ 87 ]. Several research groups enhanced the antibacterial properties of multifunctional ZnO NPs by doping with Co [ 88 ], Mn [ 89 ] and Ta [ 90 ].…”

Section: Metal Oxide Nanoparticle Hybrid Materialsmentioning

confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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“…Recent studies proposed various solutions that combine ZnO with different kinds of dressing in the form of gelatin/ointments [103], hydrogel [104,105,106], or electrospinning mats [107], made mainly with synthetic polymers or natural polymers or even a mix. Figure 6 shows a comparison between fibrous tissues manufactured by electrospinning, hydrogels, and electrospun gelatinous fibers.…”

Section: Zno–polymeric Hybrid Electrospun Nanomaterialsmentioning

confidence: 99%

“…Kantipudi et al [103] used AgNPs and Ag-ZnO composite NPs (0.1 g NPs) formulated into gel using the Carbapol 934 as a base gel, and they tested their ability to wound healing in vivo on excision wound (4 cm length and 2 mm depth) in adult male Albino Wistar rats. The composite showed good wound healing ability from the early stages, and after 10 days the wound showed fibrosis, caused by rapid epithelialization of the skin, indicating maximum effectiveness of healing.…”

Section: Zno–polymeric Hybrid Electrospun Nanomaterialsmentioning

confidence: 99%

ZnO Nanostructures and Electrospun ZnO–Polymeric Hybrid Nanomaterials in Biomedical, Health, and Sustainability Applications

et al. 2019

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ZnO-based nanomaterials are a subject of increasing interest within current research, because of their multifunctional properties, such as piezoelectricity, semi-conductivity, ultraviolet absorption, optical transparency, and photoluminescence, as well as their low toxicity, biodegradability, low cost, and versatility in achieving diverse shapes. Among the numerous fields of application, the use of nanostructured ZnO is increasingly widespread also in the biomedical and healthcare sectors, thanks to its antiseptic and antibacterial properties, role as a promoter in tissue regeneration, selectivity for specific cell lines, and drug delivery function, as well as its electrochemical and optical properties, which make it a good candidate for biomedical applications. Because of its growing use, understanding the toxicity of ZnO nanomaterials and their interaction with biological systems is crucial for manufacturing relevant engineering materials. In the last few years, ZnO nanostructures were also used to functionalize polymer matrices to produce hybrid composite materials with new properties. Among the numerous manufacturing methods, electrospinning is becoming a mainstream technique for the production of scaffolds and mats made of polymeric and metal-oxide nanofibers. In this review, we focus on toxicological aspects and recent developments in the use of ZnO-based nanomaterials for biomedical, healthcare, and sustainability applications, either alone or loaded inside polymeric matrices to make electrospun composite nanomaterials. Bibliographic data were compared and analyzed with the aim of giving homogeneity to the results and highlighting reference trends useful for obtaining a fresh perspective about the toxicity of ZnO nanostructures and their underlying mechanisms for the materials and engineering community.

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Enhanced wound healing activity of Ag–ZnO composite NPs in Wistar Albino rats

Cited by 35 publications

References 22 publications

Zinc oxide nanoparticles augment CD4, CD8, and GLUT‐4 expression and restrict inflammation response in streptozotocin‐induced diabetic rats

Zinc oxide nanoparticles augment CD4, CD8, and GLUT‐4 expression and restrict inflammation response in streptozotocin‐induced diabetic rats

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

ZnO Nanostructures and Electrospun ZnO–Polymeric Hybrid Nanomaterials in Biomedical, Health, and Sustainability Applications

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