Enhancement of Anticancer Activities from Lithospermum erythrorhizon Extracts by Ultra High Pressure Process

Seo, Yong-Chang; Choi, Woon Yong; Kim, Jinhyun; Cho, Jeong-Sub; Kim, Young-Ock; Kim, Jin Chul; Lee, Hyeon-Yong

doi:10.7783/kjmcs.2011.19.2.103

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…꾸지뽕나무의 연구는 주로 항암 (Lee et al, 1994a)과 항 산화 (Choi et al, 2009a;Chon et al, 2005;Lee et al, 1994b)에 대해 실시되었으며 항균 (Choi et al, 2009b;Lee et al, 2004), 항당뇨 (Park et al, 2001) 등에 관한 연구도 꾸준히 실시되어 다양한 효능이 밝혀지고 있다. 우리나라에서는 항암물질을 갖는 약용작물에 대한 연구는 꾸준히 진행되어 왔는데 (Ha et al, 2010;Seo et al, 2011) 특히 꾸지뽕나무의 항암 활성을 보이는 물질에 관한 연구는 Lee 등 (1994b)에 의해 시작되어 taxifolin, orobol, eridictyol, dihydrokaempferol, steppogenin 등과 같은 flavonoid계 화합 물이 분리되었고 이들의 세포독성을 비교한 결과 taxifolin을 제외한 4종의 화합물이 P388 cell (임파성백혈구계 세포)에 대 해 높은 항암 활성이 있음이 보고되었다. 또한 gericudranin A~E 등도 분리되었는데 (Lee et al, 1994a;Yoo, 1995 재료 및 방법 (Lee et al, 1996) gericudranin A의 구조를 변형시켜 더 높은 세포독성을 보이는 3-deoxygeriducranin A가 합성되기도 하였다 (Choi et al, 1997).…”

Section: 서 언unclassified

Cytotoxicity of Methanol Extracts from Cudrania tricuspidata Bureau

Choi¹,

You²,

Jang³

et al. 2012

Korean Journal of Medicinal Crop Science

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: In order to develop as a natural source of anticancer materials of Cudrania tricuspidata, the cytotoxicity of methanol extracts by harvesting parts and times against 8 cell lines including 293 (normal kidney cells) and A-431 (epidermoid carcinoma cells) were investigated using MTT assay. All harvesting parts had hardly cytotoxicity against 293. And methanol extracts of stem bark and root bark showed very high cytotoxicities against 7 cancer cell lines. The cytotoxicity was the highest against HeLa (cervix adenocarcinoma cells) and followed by MCF-7 (breast adenocarcinoma cells), AGS (stomach adenocarcinoma cells), HT-29 (colon adenocarcinoma cells), HepG2 (hepatoblastoma cells), A549 (lung carcinoma cells) and A-431. By the way, leaf extract had a cytotoxicity against only AGS and ripe fruit extract had no cytotoxicity. Among harvesting times, the cytotoxicity of root bark were high from April to September but that of stem bark showed a little difference. These results showed that anticancer activities of Cudrania tricuspidata extracts were eventful changes by harvesting parts and times.

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Section: 서 언unclassified

Cytotoxicity of Methanol Extracts from Cudrania tricuspidata Bureau

Choi¹,

You²,

Jang³

et al. 2012

Korean Journal of Medicinal Crop Science

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“…초고압 공정은 다른 식품의 보 존성과 기능성을 향상시킬 수 있고 압력을 이용해 물과 오일을 순간적으로 균일하게 전달시켜 다른 공정에 비해 화학변화가 일어나지 않는다. 단시간 내에 추출할 수 있 고, 불순물이 적게 거의 없어 고순도의 단일 성분 추출물 을 얻을 수 있는 장점이 있다 Seo et al, 2011;Jeon et al, 2013).…”

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Comparison of Saponin Content and Antioxidant Effect depending on the Processing Method of Codonopsis lanceolata

Kim

Jeon²,

Hyun

2021

Biomed Sci Letters

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Codonopsis lanceolata, called deodeok in Korean, has been verified for various effects, including anti-aging and antiinflammatory effects and insomnia improvement, and is one of the healthy foods that Koreans enjoy eating. In this study, the saponin content, lansemaside A content, and total saponin content of deodeok were analyzed using high-pressure sterilization and solid fermentation by mixed lactic acid bacteria. The antioxidant effect was compared to determine improved processing methods of deodeok. The lansemaside A content of deodeok samples depending on the preprocessing methods was analyzed: 2,594.10 mg/kg for dried deodeok, 2,100.93 mg/kg for steamed deodeok, and 1,151.31mg/kg for fermented deodeok. The total saponin content was found to be 7,209 mg/kg for dried deodeok and 8,605 mg/kg for steamed deodeok, showing a high saponin content. The total polyphenol content was highest for dried deodeok, steamed deodeok, and fermented deodeok. As for the antioxidant effect, it was analyzed that the effect of dried deodeok was the highest, followed by steamed deodeok and fermented deodeok; Dried deodeok had the highest value in total polyphenol content, not in total saponin content, which is considered to have a positive influence on its antioxidant effect. The content of lansemaside A was the highest for dried deodeok. When fermented deodeok is consumed, more beneficial effects on health can be expected by ingesting it with lactic acid bacteria cultured using saponins and polyphenols. Therefore, this study suggests the possibility of manufacturing products suitable for the needs of consumers, such as the flavor of deodeok, according to the processing methods.

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