Enhancement of nitroxide‐reducing activity in rats after chronic administration of vitamin E, vitamin C, and idebenone examined by an <i>in Vivo</i> electron spin resonance technique

Matsumoto, Seiji; Mori, Norio; Tsuchihashi, Nobuaki; Ogata, Toru; Lin, Yijing; Yokoyama, Hidekatsu; Ishida, S.

doi:10.1002/mrm.1910400219

Cited by 17 publications

(26 citation statements)

References 15 publications

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“…This may permit a potential release of dopamine during subsequent intakes of METH, resulting in active production of free radicals. When free radicals are repeatedly produced in biological systems, their radical-scavenging ability may gradually reduce (Matsumoto et al 1998). Furthermore, radical-induced neuronal damage is caused by a disruption of the balance between the toxic activity of radicals and the scavenging ability (De Vito and Wagner 1989).…”

Section: Discussionmentioning

confidence: 98%

Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

et al. 2006

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SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.

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Section: Discussionmentioning

confidence: 98%

Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

et al. 2006

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“…Consistent with no change in baseline pressure, we found no effect of tempol on basal plasma 8-isoprostane levels. Finally, tempol can cross the blood-brain barrier,65, 66 and so we cannot rule out the possibility that reductions in ROS within the central nervous system contribute to the tempol-mediated attenuation of the pressor response to acute air jet stress.…”

Section: Discussionmentioning

confidence: 99%

Endothelin Activation of Reactive Oxygen Species Mediates Stress-Induced Pressor Response in Dahl Salt-Sensitive Prehypertensive Rats

D’Angelo¹,

Loria²,

Pollock³

et al. 2010

Hypertension

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Abstract-Experiments were designed to test the hypothesis that endothelin (ET) and/or reactive oxygen species contribute to the pressor response induced by acute air jet stress in normotensive Dahl salt-sensitive rats maintained on a normal salt diet (prehypertensive). Mean arterial pressure was chronically monitored by telemetry before and after 3-day treatment with the free radical scavenger 4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol) or ET receptor antagonists ABT-627 (ET A antagonist) or A-182086 (ET A/B antagonist) supplied in the drinking water. Rats were restrained and subjected to pulsatile air jet stress (3 minutes). Plasma samples at baseline and during acute stress were analyzed for 8-isoprostane (measure of reactive oxygen species production) and ET. Neither Tempol nor ET receptor antagonist treatment had an effect on baseline mean arterial pressure or plasma 8-isoprostane. The pressor response to acute stress was accompanied by significant increases in plasma 8-isoprostane and ET. Tempol significantly reduced both the total pressor response (area under the curve) and the stress-mediated increase in plasma 8-isoprostane; conversely, Tempol had no effect on the stress-induced increase in plasma ET. Combined ET A/B antagonism, but not selective ET A receptor blockade, similarly suppressed the pressor response to stress and stress-mediated rise in 8-isoprostane. Together these results indicate that reactive oxygen species contribute to the pressor response to acute air jet stress. Furthermore, the increase in reactive oxygen species occurs downstream of ET B receptor activation. (Hypertension. 2010;56:282-289.)Key Words: endothelin Ⅲ reactive oxygen species Ⅲ air jet stress Ⅲ Dahl salt-sensitive rat Ⅲ blood pressure R eactive oxygen species (ROS) contribute to the pathogenesis of cardiovascular dysfunction associated with several diseases, including hypertension, chronic heart failure, ischemic heart disease, hyperlipidemia, and diabetes mellitus. [1][2][3] In addition, results from several laboratories suggest that ROS are implicated in normal cardiovascular function. Systemic administration of the free radical scavenger 4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) leads to significant decreases in mean arterial pressure (MAP), heart rate (HR), and sympathetic nerve activity in normotensive animals, 4 -6 suggesting an important role for ROS in the regulation of arterial pressure. Studies performed in vitro 7,8 and in vivo 9,10 also demonstrate that ROS are involved in the constrictor or pressor response, respectively, to various agonists.A growing body of evidence suggests that behavioral stress elicits production of ROS; most of these reports, however, focus on chronic stress paradigms. 11,12 Numerous studies suggest that acute stress may induce cardiovascular dysfunction, [13][14][15][16][17][18][19][20] and additional studies have shown that cardiovascular hyperreactivity is strongly associated with future cardiovascular disease. [21][22][23][24][25][26][27][28] Proposed as a m...

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“…Because the B, produced in the singleturn coil of the SCR can penetrate about 2 mm away from the center of the coil, it is considered that the half-life on the skin reflects that in the skin and the muscle (such as rectus muscle of abdomen). It is well-known that intravenously injected nitroxide radicals are reduced in the liver and other organs and excreted from the kidney [1,[7][8][9]. Nitroxide radicals are reduced to hydroxylamines by reductants [9], whereas hydroxylamines are oxidized to nitroxide radicals by oxidants such as potassium ferricyanide.…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats

et al. 2000

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Three kinds of surface-coil-type resonators (SCRs) operating at 720 MHz were fabricated for in vivo temporal electron spin resonance (ESR) measurements. The inner diameter of the singleturn coil of the SCRs was 3, 4, or 10 mm. Resonator Q increases and the detection limit decreases with coil diameter. The distance across which the microwave magnetic field can penetrate in the direction facing to the coil was about the same (about 2 mm) for all SCRs. In vivo kinetic studies of intravenously injected 4-hydroxy-2,2,6,6-tetramethylpiperidin-l-oxyl (TEMPOL) were performed at the liver, kidney, stomach, rectum, vein, and skin of rats with SCRs suited to the target areas. The halflife of TEMPOL was estimated from the exponential decay of the ESR signal intensity (the peak-topeak height). Different sites in the rat showed apparent differences in the half-life of TEMPOL. This suggests that the apparent differences in the reducing ability of TEMPOL are related to the organ or tissue where measurement is taken because no excretion of TEMPOL was observed.

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Enhancement of nitroxide‐reducing activity in rats after chronic administration of vitamin E, vitamin C, and idebenone examined by an in Vivo electron spin resonance technique

Cited by 17 publications

References 15 publications

Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

Endothelin Activation of Reactive Oxygen Species Mediates Stress-Induced Pressor Response in Dahl Salt-Sensitive Prehypertensive Rats

Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats

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