Enhancing Allograft Bone Healing Through Gene Therapy

Rubery, Paul T.

doi:10.1097/brs.0b013e3181ccc7bf

Cited by 7 publications

(7 citation statements)

References 54 publications

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“…Radiological examinations were performed on X-rays and computed tomography (CT) at preoperative and postoperative visits (6,12,24, and 36 months) by the authors (L.P.; R.A.) in a blinded fashion. Two patients were lost to follow-up in the SiCaP group but had available treatment and complication data included in the results in the interest of completeness, groups, with the SiCaP patients progressing more slowly toward solid fusion.…”

Section: Radiological Assessmentmentioning

confidence: 99%

“…ICBG, for instance, has been associated with chronic donor site pain, infections, fractures, and hematomas. [14][15][16] Thus, graft materials and adjuvants other than ICBG were developed, such as synthetics grafts (calcium phosphate injectable cements, hydroxyapatite, and β-tricalcium phosphate), [17][18][19][20][21] allograft cellular bone matrix, 22 gene therapies, 23,24 demineralized bone matrix 25 and recombinant growth factors. 26 However, each of these non-ICBG materials (except for allograft cellular bone matrix) lack the three physiologic mechanisms of bone formation that ICBG possesses: osteoconduction, osteoinduction, and osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

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A Prospective, Randomized, Controlled Trial Comparing Radiographic and Clinical Outcomes between Stand-Alone Lateral Interbody Lumbar Fusion with either Silicate Calcium Phosphate or rh-BMP2

Pimenta

Marchi

Oliveira

et al. 2013

J Neurol Surg A Cent Eur Neurosurg

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Section: Radiological Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Prospective, Randomized, Controlled Trial Comparing Radiographic and Clinical Outcomes between Stand-Alone Lateral Interbody Lumbar Fusion with either Silicate Calcium Phosphate or rh-BMP2

Pimenta

Marchi

Oliveira

et al. 2013

J Neurol Surg A Cent Eur Neurosurg

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“…The use of autografts remains the gold standard in treatment of large bone defects. However, there remain significant limitations of autografts, including: increased risk of infection due to longer operative times and a second surgical incision, dramatic harvest site morbidity and pain, as well as damage to local neurovascular structures . As a result, there is a need to explore bone substitutes with desired biological and mechanical properties for these large bone defects.…”

Section: Introductionmentioning

confidence: 99%

Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials – A General Review

Liu

Chen

Zheng

et al. 2017

Adv Healthcare Materials

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Vascularization is an essential process in bone formation, remodeling and regeneration during both bone development and fracture repair. Vascularization remains a big challenge directly leading to the final success of newly regenerated bone. In this review, the advantages and disadvantages of different angiogenesis assays and bone defect models are described in details for investigating revascularization of materials of interest. Unlike conventional angiogenesis study with growth factors or pharmaceutical molecules performed in two-dimension, special considerations are taken into account whether these assays can be translated for testing three-dimensional implantable devices. Over the years, accurate and quantifiable in vitro, ex vivo and in vivo assays have been extensively demonstrated to be useful in examining how new blood vessels grow. These methods can contribute to the fundamental understanding of angiogenic properties of the materials, but a bone defect model is still pivotal in order to understand the cascade actions of angiogenesis along with bone formation. Finally, angiogenesis and osteogenesis are both complex processes interacting with each other, the choice of which assay to be performed should adequately address the clinical relevance and reflect the sequence of responses of revascularization of the test materials.

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“…In particular, the grafts can be reshaped to better match the defects, and with the help of screws and plates, the grafts can be properly stabilized. Many factors affect the healing of allograft bone 27 . Most allografts achieve union in the first 3–4 months after surgery 28,29 .…”

Section: Discussionmentioning

confidence: 99%

A new joint reconstruction technique in the treatment of giant cell tumors around the knee: Structural allograft and unicompartmental arthroplasty

Liu

Zhang

et al. 2023

Journal of Surgical Oncology

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ObjectiveThe long‐term prognosis of patients who underwent unicompartmental knee arthroplasty (UKA) with a structural allograft or hemiarticular allograft transplantation to treat giant cell tumors (GCTs) around the knee and the prosthesis survival rate were analyzed.MethodsWe retrospectively reviewed 73 patients who were diagnosed with GCTs around the knee and underwent surgery to restore joint function from 2000 to 2015. Patients were divided into two groups according to the surgical procedure used for functional knee reconstruction: hemiarticular allograft transplantation or structural allograft and UKA. The Knee Society Score (KSS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were used to analyze postoperative knee function between the two groups. The Kellgren‐Lawrence (K–L) classification system was used to evaluate the progression of osteoarthritis. The incidence of complications and the prosthesis survival rate were also investigated.ResultsPatients who underwent UKA to treat GCT demonstrated significantly improved knee function. The rate of an excellent or good KSS was significantly different between the two groups (p = 0.041 at the 1‐year follow‐up, p = 0.033 at the last follow‐up). The proportion of severe cases according to WOMAC in the two groups was also different (p = 0.030 at the 1‐year follow‐up, p = 0.021 at the last follow‐up). According to the K–L grade of unaffected compartments, UKA better prevented the progression of osteoarthritis (p = 0.034).ConclusionsPatients with GCTs around the knee could benefit from UKA. In addition to providing better knee function and range of motion, UKA could also slow the progression of osteoarthritis in the knee joint. This new surgical method could meet the needs of patients wishing to preserve joint integrity and favorable joint function.

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Enhancing Allograft Bone Healing Through Gene Therapy

Abstract: Gene therapy techniques can create revitalized allografts in a mouse model. These revitalized grafts heal faster, more completely, more durably, and stronger than allografts.

Cited by 7 publications

References 54 publications

A Prospective, Randomized, Controlled Trial Comparing Radiographic and Clinical Outcomes between Stand-Alone Lateral Interbody Lumbar Fusion with either Silicate Calcium Phosphate or rh-BMP2

A Prospective, Randomized, Controlled Trial Comparing Radiographic and Clinical Outcomes between Stand-Alone Lateral Interbody Lumbar Fusion with either Silicate Calcium Phosphate or rh-BMP2

Angiogenesis Assays for the Evaluation of Angiogenic Properties of Orthopaedic Biomaterials – A General Review

A new joint reconstruction technique in the treatment of giant cell tumors around the knee: Structural allograft and unicompartmental arthroplasty

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