Enhancing bioavailability and hepatoprotective activity of andrographolide fromAndrographis paniculata, a well-known medicinal food, through its herbosome

Abstract

The results proved that the andrographolide complex produced by this method has better bioavailability and hence improved hepatoprotective activity compared with andrographolide at the same dose. Andrographolide complexation is therefore helpful in solving the problem of rapid clearance and low elimination half-life associated with andrographolide from A. paniculata.

Hepatoprotective activity of Hepax–A polyherbal formulation

“…Depletion of GSH causes the remaining quinone to undergo covalent bonding with cellular macromolecules (sulphydryl groups of protein) and leads to cell death. Histopathology of the liver shows necrosis of the centrilobular hepatocytes characterized by nuclear pyknosis, eosinophilic cytoplasm and large excessive hepatic lesions [15] .…”

The Gallic Acid–Phospholipid Complex Improved the Antioxidant Potential of Gallic Acid by Enhancing Its Bioavailability

“…Therefore, to get desirable therapeutic activity, it is required to improve the bioavailability and reduce the elimination of GA. Complexation with hydrogenated soy phosphatidylcholine (HSPC), which is an important carrier of drug molecule, can improve the bioavailability and elimination-related problems. The recent studies in our laboratory with andrographolide, ellagic acid, and naringenin demonstrated that complexation with phospholipid improves the bioavailability and enhances the bioactivity of these phytochemicals (18)(19)(20) which is may be due to sustainedrelease delivery of the complex (21). So, the aim of this work was to develop GA-HSPC complex, to evaluate the effect of complexation on hepatoprotective and in vivo antioxidant activity of the complex in CCl 4 -intoxicated rats, and to study how the level of GA in rat plasma is improved along with the main pharmacokinetic parameters due to complex formation.…”

Molecular Docking of HIV-1 env gp120 Using Diterpene Lactones from Andrographis paniculata

“…Andrographolide, a bicyclic diterpenoid lactone, the main constituent of Andrographis paniculata is known for its pharmacological activities. Andrographolide is known to possess antihepatotoxic [3], antibiotic [4], anti-inflammatory [5], anti-snake venom [6], anticancerous [7] and anti-HIV [8] properties. Besides all it is generally used as immunostimulant [9] agent.…”