Enhancing Bone Healing with Autogenous Prp And Hyaluronic Acid: An Experimental Study

Abstract

Objective: The aims of this study was to unveil the accelerated bone healing potential of PRP and HA, either separately or in a mixture. By evaluating their impact on tissue response, inflammation, granulation tissue formation, and osteoid presence. Background. This experimental study explores the dynamic interplay of Platelet-rich plasma (PRP) and Hyaluronic acid (HA) in this context. PRP, rich in growth factors, has emerged as a potential substitute for traditional bone grafts, while HA plays a crucial role in tissue morphogenesis and bone regeneration. This research investigates their combined effects and individual contributions to bone healing acceleration. Methods: Twenty-five adult male rabbits were introduced in the study and divided the subjects into five groups (each group 5 rabbits). Surgical procedures were performed, followed by postoperative assessments at intervals (days 3, 7, 14, 21, and 28). Bone healing progression was evaluated using a histopathological and computed tomography CT scans. Results: PRP alone demonstrated significant a cumulative effect over time, enhancing bone density. Similarly, HA exhibited noteworthy improvements at later stages. However, their combination showed significant differences compared to the control group, highlighting a potential synergistic effect on bone healing at days 14, 21, and 28. Conclusion: The combination between PRP and HA holds promise for bone healing enhancement, potentially reshaping clinical approaches.