Enhancing Natural Killer Cell Activity

Ghoneum, Mamdooh

doi:10.1007/978-981-19-5735-2_2

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…RBAC was shown to be an immunomodulator by activating NKC [10,11,41,42,[73][74][75][76][77][78][79] and macrophages [9,42,[80][81][82][83][84][85][86][87][88]. Notably, the ability to enhance NKC cytotoxic activity has also been discussed in many other reviews [14,20,22,89]. RBAC also exerted influences over other immune cells, such as T and B lymphocytes [9,75,76,78,80,82,[90][91][92], dendritic cells [41,86,90,91,93] and neutrophils [94,95], by affecting the production of cytokines to regulate their activities [78, 82-84, 94, 96, 97].…”

Section: Plos Onementioning

confidence: 99%

Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis

Ooi,

Micalos,

Pak

2023

PLoS ONE

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Rice bran arabinoxylan compound (RBAC) is a polysaccharide modified by Lentinus edodes mycelial enzyme widely used as a nutraceutical. To explore translational research on RBAC, a scoping review was conducted to synthesise research evidence from English (MEDLINE, ProQuest, CENTRAL, Emcare, CINAHL+, Web of Science), Japanese (CiNii, J-Stage), Korean (KCI, RISS, ScienceON), and Chinese (CNKI, Wanfang) sources while combining bibliometrics and network analyses for data visualisation. Searches were conducted between September and October 2022. Ninety-eight articles on RBAC and the biological activities related to human health or disease were included. Research progressed with linear growth (median = 3/year) from 1998 to 2022, predominantly on Biobran MGN-3 (86.73%) and contributed by 289 authors from 100 institutions across 18 countries. Clinical studies constitute 61.1% of recent articles (2018 to 2022). Over 50% of the research was from the USA (29/98, 29.59%) and Japan (22/98, 22.45%). A shifting focus from immuno-cellular activities to human translations over the years was shown via keyword visualisation. Beneficial effects of RBAC include immunomodulation, synergistic anticancer properties, hepatoprotection, antiinflammation, and antioxidation. As an oral supplement taken as an adjuvant during chemoradiotherapy, cancer patients reported reduced side effects and improved quality of life in human studies, indicating RBAC’s impact on the psycho-neuro-immune axis. RBAC has been studied in 17 conditions, including cancer, liver diseases, HIV, allergy, chronic fatigue, gastroenteritis, cold/flu, diabetes, and in healthy participants. Further translational research on the impact on patient and community health is required for the evidence-informed use of RBAC in health and disease.

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Section: Plos Onementioning

confidence: 99%

Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis

Ooi,

Micalos,

Pak

2023

PLoS ONE

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“…Biobran/MGN-3 was also found to show substantial anticancerous activity in various experiments on rats and mice. In humans, as well, biobran/MGN-3 was reported to show positive results against several malignancies type via enhancing the natural killer cell activity (Ghoneum, 2023). Similarly, Japanese fermented brown rice with Aspergillus oryzae (FBRA-1) has been found to show carcinogenic preprotection activity in the urinary bladder, stomach, lungs, colon, and liver of rodents.…”

Section: Anticancerous Activitymentioning

confidence: 99%

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

Kumar

Singh

Sharma

2023

eFood

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Rice is an essential crop, growing in nearly every part worldwide. Grains are the most common rice plant part consumed as food; however, other plant parts also have some significant values apart from grains. Rice bran is the outer layer of the rice grain, an excellent source of various phenolic, flavonoid, and phytoactive compounds. This review article discusses the various compounds found in rice bran with their structure and properties. Different medicinal properties of rice bran are also discussed in this review article. Several constituents of rice bran show anticancerous activity through various mechanisms like cell cycle arrest and regulation of apoptotic factors. Anti‐inflammatory, antidiabetic, antihypertensive, and cholesterol‐lowering are the other activities of rice bran, briefly explained in the article, along with their mechanism of action. A bibliographic network, including keyword bibliography analysis and a three‐field plot, has also been discussed to show the trends and network of common keywords in the recently published documents in the Scopus database. Overall, this review explores the rice bran compositions with their structures, activity, and various medicinal uses of rice bran, which can be proven an efficient oil source for nutritional purposes.

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Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms

Ooi,

Micalos,

Kim

et al. 2024

Pharmaceutical Biology

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Context Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties. Objective This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment. Methods This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis. Results The evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year. Conclusion RBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.

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Enhancing Natural Killer Cell Activity

Cited by 3 publications

References 35 publications

Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis

Modified rice bran arabinoxylan as a nutraceutical in health and disease—A scoping review with bibliometric analysis

Recent trends of potential medicinal uses of rice bran with its composition and bibliographic analysis

Rice bran arabinoxylan compound as a natural product for cancer treatment – an evidence-based assessment of the effects and mechanisms

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