Enhancing protease enantioselectivity by ionic liquids based on chiral- or ω-amino acids

Hofmeister effects: an explanation for the impact of ionic liquids on biocatalysis

“…Coincidently, all these successful IL designs share the same structural pattern, i.e., they are all water-mimicking and holding chaotropic cations and kosmotropic anions. Moreover, Zhao et al (2006d) have prepared ILs carrying anions of chiral-or -amino acids for the enzymatic hydrolysis of l-phenylalanine methyl ester. A higher enantioselectivity was generally observed in the ILs based on d-amino acids rather than in the ILs derived from l-isomers, presumably because the d-form is more kosmotropic.…”

The surface tension, density and refractive index of amino acid ionic liquids: [C3mim][Gly] and [C4mim][Gly]

“…As a new-generation ''greener ionic liquid'', amino acid ionic liquids (AAILs) are synthesized from natural amino acids [1,2], which are easily biodegradable, and have attracted considerable attention from industry and the academic community [1][2][3][4][5][6][7]. AAILs have strong hydrogen-bonding ability, which is useful for dissolving biomaterials such as DNA and other carbohydrates.…”

Evaluation of the biocompatibile ionic liquid 1-methyl-3-methylimidazolium dimethylphosphite pretreatment of corn cob for improved saccharification

“…As a result, recent efforts have been focused on exploration of enzymefriendly and environment-friendly ionic liquids (Roosen et al 2008), because green solvent is promising for commercial application (Kamiya et al 2008). Although deactivation of cellulase in the presence of low concentrations of [Bmim]Cl, a typical cellulose-treated IL, was demonstrated (Turner et al 2003), up to 60% (v/v) of [Emim][OAc] and DMEAA gave to enzymatic resolution of amino acids (Zhao et al 2006;Rayne and Mazza 2007), implying that the anionic component of ILs plays a key role in enzymatic catalysis. Moreover, Kamiya reported enzymatic saccharification process in presence of moderate concentration of IL 1-ethyl-3-methylimidazolium diethylphosphate (Kamiya et al 2008).…”