Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy

Yoon, Paul; Tsvankin, Vadim; Shrock, Zachary; Meng, Boyu; Zhang, Xiaofeng; Dewhirst, Mark W.; Fecci, Peter E.; Adamson, Justus; Oldham, Mark

doi:10.1016/j.ijrobp.2017.11.013

Cited by 23 publications

(24 citation statements)

References 20 publications

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“…[70] Despite this weakness of the CL, several authors have attributed an improved anticancer effect of their nanomaterials combined with radioisotopes to a Cherenkov process. [66,71,72] Table 1. Radiolytic yield, half-life and approximate migration distance of main radiolysis products in water.…”

Section: Light Generation By Radiation: Cherenkov Effectmentioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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Engineered nanomaterials that produce reactive oxygen species on exposure to X‐ and gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies. Similar to photodynamic therapy but suitable for large and deep tumors, this new approach where nanomaterials acting as sensitizing agents are combined with clinical radiation can be effective at well‐tolerated low radiation doses. Suitably engineered nanomaterials can enhance cancer radiotherapy by increasing the tumor selectivity and decreasing side effects. Additionally, the nanomaterial platform offers therapeutically valuable functionalities, including molecular targeting, drug/gene delivery, and adaptive responses to trigger drug release. The potential of such nanomaterials to be combined with radiotherapy is widely recognized. In order for further breakthroughs to be made, and to facilitate clinical translation, the applicable principles and fundamentals should be articulated. This review focuses on mechanisms underpinning rational nanomaterial design to enhance radiation therapy, the understanding of which will enable novel ways to optimize its therapeutic efficacy. A roadmap for designing nanomaterials with optimized anticancer performance is also shown and the potential clinical significance and future translation are discussed.

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Section: Light Generation By Radiation: Cherenkov Effectmentioning

confidence: 99%

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

et al. 2020

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“…Mediated by the Cherenkov light generated by MV x-rays, psoralens have recently shown radiosensitizing properties for low-dose fractionated radiotherapy, both in vitro and in preclinical tumor models in vivo. 60,61 This novel approach is thought to be based on fundamentally different mechanisms of action than conventional physical or chemical radiosensitizers. There are also potential synergistic interactions in x-ray-induced photosensitization using nanoparticles, as discussed below.…”

Section: Emerging and Future Medical X-ray Technologies Enabled By Opmentioning

confidence: 99%

“…Examples of x-ray-mediated phototherapeutics with psoralen photosensitization by Cherenkov light. (a) Spectral overlap of Cherenkov light and psoralen absorption, relative to the UVA light used in PUVA 61. (b) Scintillating CeF 3 nanocrystals coupled with photosensitizer (VP), with spectral overlap of the scintillation emission with the Soret band of VP, producing singlet-oxygen ( 1 O 2 ) from collisional quenching by molecular oxygen (O 2 ) 135.…”

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confidence: 99%

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

Pogue

Wilson

2018

J. Biomed. Opt.

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X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues. However, optical photon energies are comparable with molecular energy levels, thereby providing the strength of intrinsic molecular specificity. Additionally, optical technologies are highly advanced and diversified, being ubiquitously used throughout medicine as the single largest technology sector. Both have dominant spatial localization value, achieved with optical surface scanning or x-ray internal visualization, where one often is used with the other. Therapeutic delivery can also be enhanced by their synergy, where radiooptical and optical-radio interactions can inform about dose or amplify the clinical therapeutic value. An emerging trend is the integration of nanoparticles to serve as molecular intermediates or energy transducers for imaging and therapy, requiring careful design for the interaction either by scintillation or Cherenkov light, and the nanoscale design is impacted by the choices of optical interaction mechanism. The enhancement of optical molecular sensing or sensitization of tissue using x-rays as the energy source is an important emerging field combining x-ray tissue penetration in radiation oncology with the molecular specificity and packaging of optical probes or molecular localization. The ways in which x-rays can enable optical procedures, or optics can enable x-ray procedures, provide a range of new opportunities in both diagnostic and therapeutic medicine. Taken together, these two technologies form the basis for the vast majority of diagnostics and therapeutics in use in clinical medicine.

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“…We thank Drs. Pratx and Kapp for their interest in the RECA approach (Radiotherapy Enhanced by Cherenkov photo-Activation) and for raising valuable questions (1, 2).…”

Section: To the Editormentioning

confidence: 99%

In Reply to Pratx and Kapp

Oldham

Yoon

Adamson

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy

Abstract: This work demonstrates for the first time the potential for photo-activation of psoralen directly in situ, from Cherenkov light generated by a clinical megavoltage treatment beam.

Cited by 23 publications

References 20 publications

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Mechanisms for Tuning Engineered Nanomaterials to Enhance Radiation Therapy of Cancer

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine

In Reply to Pratx and Kapp

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