Enhancing Sublingual Tablet Quality through QbD: Current Trends and Insights"

Abstract

The field of pharmaceutical development has witnessed a significant shift toward implementing Quality by Design (QbD) principles to enhance the quality, safety, and efficacy of various drug delivery systems. As a promising alternative to traditional oral dosage forms, sublingual tablets have gained attention for their rapid onset of action and improved patient compliance. This re-view article aims to provide a comprehensive overview of the fundamental principles of QbD and its relevance in the context of sublingual tablets. It delves into the intricate relationship between Critical Quality Attributes (CQAs) and Critical Process Parameters (CPPs), emphasizing the necessity of a systematic approach to achieving product excellence. Furthermore, the article highlights the benefits of implementing QbD in sublingual tablet development, potential challenges, and the regulatory landscape for QbD in pharmaceutical development.