Enhancing sustained drug release property of chitosan in spheroids through crosslinking reaction and coacervation

Zakaria, Lidawati; Wong, Tin Wui; Anuar, Nor Khaizan; Naharudin, Idanawati; Tripathy, Minaketan; Sheshala, Ravi; Hussain, Zahid

doi:10.1016/j.powtec.2019.07.006

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…The in vitro release studies were carried out at 37 °C, where 30.0 mg of SR-Sf-SD sample was inserted into a cellulose bag (Millipore HAWPO4700MF smooth membrane) and acconditioned within the fluorescence quartz cuvette containing 3 mL of the F127 receptor solution (4.0% w/v) at pH 7.4, guaranteeing the sink condition . The system was kept under constant agitation, and the kinetic profile of release was monitored by the acquisition of spectra (kinetic mode) of electronic absorption and fluorescence emission. , …”

Section: Methodsmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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Safranine-O (Sf) is a photosensitizer (PS) displaying a remarkable potential for photodynamic therapy (PDT). In this work, we have used the combination of Sf with F127 Pluronic and Carbopol (C934P) to obtain a stimuliresponsive hydrogel (SR-Sf). This thermoresponsive-photoactive nanostructured system was prepared by two different methods: direct addition (DA) and solid dispersion (SD). Both SR-Sf have had their physical and chemical properties evaluated for veterinary applications, especially considering their ability to be used as a commercial product, aiming at the prophylactic or therapeutic treatment of breast gland infections. In general, the rheological and mechanical properties, as well as the sol−gel transition temperature, indicated suitable properties for using them as a topical system in veterinary (and human) applications. The ex vivo release studies showed a satisfactory permeation profile of the SR-Sf hydrogel, reaching the full length of the overall skin toward the dermis within 30 min of application (989 μm). The in vitro studies showed photodynamic inactivation using Sf-F127 with a significant reduction in isolated colonies. The in vivo case report with dairy goat demonstrated that the SR-Sf hydrogel veterinary use platform emerged as an innovative approach for the treatment of local infections without generating antibiotic residues in the milk produced.

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Section: Methodsmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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“…The release test was performed on a SR-8 Plus Hanson Research, dissolution system using apparatus I (basket), under agitation speed of 50 rpm and 37.0 ± 0.4 °C, with a precisely weighed mass of samples containing the same drug content. A total of 500.0 mL phosphate buffer was used as a dissolution medium (0.1 mol∙L −1 , pH 7.4), ensuring sink conditions [71,72].…”

Section: Methodsmentioning

confidence: 99%

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

Lima

Coêlho

Silva³

et al. 2019

Materials

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Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol–gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug. The systems were characterized by X-ray diffraction (XRD), Therma analysis TG/DTG, and Fourier-transform infrared spectroscopy (FTIR) that supported the DDS’s formation. The hybrid showed a better drug incorporation capacity compared to the precursors, with a loading of 55.74, 49.53, and 4.71 mg g−1 for Talc + Ch, Talc, and Ch, respectively. The release assays were performed on a Hanson Research SR-8 Plus dissolver using apparatus I (basket), set to guarantee the sink conditions. The in vitro release tests showed a prolongation of the release rates of this drug for at least 4 h. This result proposes that the systems implies the slow and gradual release of the active substance, favoring the maintenance of the plasma concentration within a therapeutic window.

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“…Chitosan is a biopolymer used in a large area of applications due to its beneficial properties such as biocompatibility, biodegradability and antimicrobial activity [1][2][3][4][5]. Among these applications, its use as a matrix for drug delivery holds the promise to overcome the side effects of the systemic administration, i.e.…”

Section: Introductionmentioning

confidence: 99%

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

Himiniuc¹,

Agop²,

Ghizdovăţ³

et al. 2021

Mater. Plast.

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Controlled drug release is a promising pathway of biomedicine, meant to suppress side effects with the aim of increasing patient s comfort. A route to achieve this goal represents the encapsulation of drugs into matrixes, capable to develop physical forces, which further can control the drugs release. To this purpose, mathematical modeling is an important tool, which offers the possibility to understand the drug release mechanisms and to further design new performant systems. In this paper, a theoretical model for drug release from an amphiphilic matrix is presented. This is achieved using a conservation multifractal law of probability density followed by validation of the model. Moreover, because non-steroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are widely used in endometriosis as painkillers for dysmenorrhea management or Asherman syndrome for reducing the endometrial inflammation, some implications of our model for drug delivery systems applied in the field of gynecology have been discussed.

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Enhancing sustained drug release property of chitosan in spheroids through crosslinking reaction and coacervation

Cited by 11 publications

References 11 publications

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release

A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

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