Enhancing the Aspirin Loading and Release Efficiency of Silver Oxide Nanoparticles Using Oleic Acid‐based Bio‐Surfactant from Enteromorpha intestinalis

Abstract

This study is an attempt to improve the loading and release potential of silver oxide nanoparticles (AgO NPs) using Oleic acid based bio-surfactant isolated from Enteromorpha instestinalis. The isolated Oleic acid based bio-surfactant was characterized using GC-MS, NMR, and HPLC. The AgO NPs were then surface-functionalized with the bio-surfactant and analyzed using XRD, HR-TEM/SAED, DLS, UV-Vis, and FTIR spectroscopy to evaluate the loading of aspirin and functional groups responsible for loading. The model drug Aspirin that has depreciated bio-availability due to poor solubility was used to test the drug carrier efficiency of the AgO NPs after the surface-functionalization. The loading of aspirin was increased by up to 80% in bio-surfactants than PEGcoated NPs (72%) at a 1:1 ratio (Aspirin/NP). The drug release profile of aspirin was evaluated by dialysis at different acidic conditions (pH 1.2, 6.8, and 7.4) and the active release of aspirin was observed in pH 6.8 and bio-surfactant produced better release than PEG and commercial tablet in all the pH conditions. To identify the mechanism of release from the carrier, the release kinetics was studied using zero-order, first-order, Higuchi's, and Korsmeyer Peppas equations and found that the release was time-dependent and non-fickian.

Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy

“…The supernatants during the loading process were measured directly by HPLC, which indicated the higher drug loading capacity of OA-MSNs than that of MSNs-NH 2 . Such high drug loading capacity of the nanocomposite can be explained by the lipophilic surface of OA grafted MSNs facilitating the adsorption of hydrophobic molecules [ 53 , 54 ]. Moreover, efficient DTX loading in the OA-MSNs was also attributed to the formation of hydrogen bonds between their functional groups [ 55 ].…”

A review on the physicochemical and biological applications of biosurfactants in biotechnology and pharmaceuticals

“…Since biosurfactants efficiently create liquid crystals in aqueous solutions, they can be used to produce superior nanomaterials. In addition to silver and iron oxide nanomaterials, biosurfactants assisted gold nanoparticles have also found considerable use in medical and health technologies [104,105]. Additionally, Aminabhavi et al used ultrasonic irradiation to create the nanostructured materials using green sonochemical methods.…”

Pollen-derived microcapsules for aspirin microencapsulation: in vitro release and physico-chemical studies

“…loading the drug on metallic nanoparticles, encapsulating in emulsions and/or natural microcapsules. 15,16 This study also presents a solution for the ASA poor solubility.…”

“…The pure ASA showed bands at 3001 cm À1 , 2871 15. cm À1 , 2699.21 cm À1 are associated with O-H stretching vibration of carboxylic acid groups.…”