The growing production of coke and, consequently, coke wastewater is a significant problem for the environment. Coke wastewater, because it contains high amounts of toxic substances, is classified as an extremely hazardous industrial wastewater. The treatment of such wastewater requires a combination of advanced physicochemical and biological methods. The aim of the research was to investigate the effectiveness of the application of the ultrasonic disintegration of coke wastewater in a sequencing batch reactor (SBR). The tests were conducted in two stages, wherein the first stage involved determining the most favorable sonication conditions, that is, time and amplitude. The authors used the following amplitudes: 31 µm; 61.5 µm; 92 µm; 123 µm and times: 120 s; 240 s; 480 s; 960 s. The second stage focused on treating coke wastewater in SBRs (Reactor A—a proportion of coke wastewater in the mixture: 5%, 10%, and 20%; reactor B—sonicated coke wastewater, proportion in mixture: 5%, 10%, 20%). The efficiency of the treatment process was determined based on the rate of removal of selected parameters: chemical oxygen demand (COD), total organic carbon (TOC), inorganic carbon (IC), ammoniacal nitrogen (N-NH4), total nitrogen (TN), the course of pH changes. The study revealed that sonication of coke wastewater increased biodegradability and reduced its toxicity. The use of the preliminary sonication of coke wastewater before biological treatment improved the degree of removal of the tested parameters by approximately 10%. The volumetric ratio of coke wastewater in the mixture had the greatest impact on the obtained results. The use of an ultrasound field allows the treatment process to be executed with a coke wastewater addition exceeding 10%. In addition, it was found that in order to increase the coke wastewater treatment efficiency, one should optimize individual phases in the SBR and the pollution load.