Enhancing the Solubility and Transdermal Delivery of Drugs Using Ionic Liquid‐In‐Oil Microemulsions

Lü, Beibei; Bo, Yiyang; Yi, Mingjie; Wang, Zhenyuan; Zhang, Jiaheng; Zhu, Zhenye; Zhao, Yanli

doi:10.1002/adfm.202102794

Cited by 43 publications

(30 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the aim of overcoming these issues, several attempts have been made to improve solubility, dissolution rate, and bioavailability of poorly water-soluble drugs, leading to the development of novel formulations (amorphous systems, microemulsions, inclusion of cyclodextrins, and solid dispersions), as well as the application of new technologies (hot melt extrusion and spray drying) [2,[5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Clay-Based Hydrogels as Drug Delivery Vehicles of Curcumin Nanocrystals for Topical Application

et al. 2022

View full text Add to dashboard Cite

The poor water solubility of a significant number of active pharmaceutical ingredients (API) remains one of the main challenges in the drug development process, causing low bioavailability and therapeutic failure of drug candidates. Curcumin is a well-known Biopharmaceutics Classification System (BCS) class IV drug, characterized by lipophilicity and low permeability, which hampers topical bioavailability. Given these premises, the aim of this work was the design and the development of curcumin nanocrystals and their incorporation into natural inorganic hydrogels for topical application. Curcumin nanocrystals were manufactured by the wet ball milling technique and then loaded in clay-based hydrogels. Bentonite and/or palygorskite were selected as the inorganic gelling agents. Curcumin nanocrystal-loaded hydrogels were manufactured by means of a homogenization process and characterized with respect to their chemico-physical properties, in vitro release, antioxidant activity and skin permeation. The results highlighted that the presence of bentonite provided an increase of curcumin skin penetration and simultaneously allowed its radical scavenging properties, due to the desirable rheological characteristics, which should guarantee the necessary contact time of the gel with the skin.

show abstract

Section: Introductionmentioning

confidence: 99%

Clay-Based Hydrogels as Drug Delivery Vehicles of Curcumin Nanocrystals for Topical Application

et al. 2022

View full text Add to dashboard Cite

show abstract

“…1a, a broad peaks between 3000-3700 cm − 1 was linked to -OH stretching vibrations involved in the hydrogen bond interaction. (Lu et al 2021) The absorption peaks observed at 2922 cm − 1 and 2848 cm − 1 corresponded to C-H stretching vibrations from CH and CH 2 in cellulose, hemicellulose and lignin. Similarly, multiple peaks in the regions between 1000-1800 cm − 1 were related to the functional groups in cellulose, hemicellulose and lignin of the plant.…”

Section: Chemical Structure and Morphology Characterization Of M-ca/jeppmentioning

confidence: 96%

High performance Juncus effusus cellulosic adsorbent modified with citric acid and magnetic Fe3O4 for dye wastewater

Zhou

Yan

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

Eco-friendly cellulose-based magnetic adsorbents have attracted great attention in the field of dye adsorption recently. Herein, we utilized the pith of biomass Juncus effusus (JE) to synthesize a novel type of magnetic adsorbents for the treatment of wastewater containing methylene blue (MB). After employing citric acid (CA) for esterified modification and then loading Fe3O4 upon JE, the obtained magnetic citric acid-modified JE pith powders (M-CA/JEPP) showed outstanding adsorption properties. For 50 mg/L MB dye solution, the adsorption efficiency could reach 98.34% within 10 min under basic condition and the maximum adsorption capacity was 293.132 mg/g at 303 K. Moreover, magnetization overcomes the disadvantages of JE powders density being small which is very difficult to collect. In the other words, this magnetic adsorbent has excellent reusability and it is easily to be separated from water, which provides new insights for development of cellulose-based adsorbents to remove dye in aqueous systems.

show abstract

“…Ionic liquids (ILs) have been reported to improve drug solubility and tissue permeability. ,− For instance, Samir Mitragotri et al reported the use of novel IL (choline glycolate) through intestinal injection to deliver drugs to the intestine. The IL can significantly improve the absorption of drugs in the intestine via reducing the viscosity of mucus and enhancing the drug paracellular transport .…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Ionic Liquid by Interfacial Self-Assembly of Metal-Phenolic Network for Efficient Gastric Absorption of Oral Drug Delivery

Shen

Zhang

Feng

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Improving bioavailability of orally delivered drugs is still challenging, as conventional drug delivery systems suffer from non-specific drug delivery in the gastrointestinal (GI) tract and limited drug absorption efficiency. Gastric drug delivery is even more difficult due to the harsh microenvironment, short retention time, and physiologic barriers in the stomach. Here, an oral drug delivery microcapsule system was developed for gastric drug delivery, which consists of ionic liquid (IL) as the inner carrier and metal-phenolic network (MPN) as the microcapsule shell. The IL@MPN microcapsules are prepared by interfacial self-assembly of Fe III and quercetin at the interface of hydrophobic IL ([EMIM][NTf 2 ]) and water. The formation of MPN shell could improve the stability of IL droplets in water and endow the system with pH-response drug release properties, while the encapsulated IL core could efficiently load the drug and enhance the drug tissue permeability. The IL@MPN microcapsules showed enhanced drug absorption in the stomach after oral administration in a rat model, where the microcapsules are disassembled in gastric acid, and the released IL could reduce the viscosity of mucus gel and increase the drug transport rate across endothelial cells. This work presents a simple yet efficient strategy for oral drug delivery to the stomach. Given the diversity and versatility of both MPN and IL, the proposed self-assembled microcapsules could expand the toolbox of drug delivery systems with enhanced oral drug bioavailability.

show abstract

Enhancing the Solubility and Transdermal Delivery of Drugs Using Ionic Liquid‐In‐Oil Microemulsions

Cited by 43 publications

References 48 publications

Clay-Based Hydrogels as Drug Delivery Vehicles of Curcumin Nanocrystals for Topical Application

Clay-Based Hydrogels as Drug Delivery Vehicles of Curcumin Nanocrystals for Topical Application

High performance Juncus effusus cellulosic adsorbent modified with citric acid and magnetic Fe3O4 for dye wastewater

Microencapsulation of Ionic Liquid by Interfacial Self-Assembly of Metal-Phenolic Network for Efficient Gastric Absorption of Oral Drug Delivery

Contact Info

Product

Resources

About