Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity

Mahati, K.; Bhagya, V.; Christofer, Thomas; Sneha, A.; Rao, B.S. Shankaranarayana

doi:10.1016/j.nlm.2016.08.017

Cited by 60 publications

(39 citation statements)

References 134 publications

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“…: 108 cm × 65 cm × 65 cm) in groups of 10 to 12 rats for 6 hr/day (10 AM and 4 PM) for a 10‐day period with food and water ad libitum. The cage contained toys of different sizes and materials (plastic, wood, and metal), climbing ladders, and tunnels (Veena et al, ; Mahati et al, ). To maintain novelty, all objects were changed on alternative days.…”

Section: Methodsmentioning

confidence: 99%

“…Hippocampal slices were prepared as described earlier (Bhagya et al, ; Mahati et al, ). Briefly, the rats from different groups were deeply anesthetized with halothane.…”

Section: Methodsmentioning

confidence: 99%

“…After 20 min of stable baseline recordings at 0.033 Hz (one sweep per 30 sec), a single train of high‐frequency stimulation (HFS, 100 Hz, 1 sec) was delivered to induce LTP and recorded for 60 min. Data acquisition and analysis were performed using LTP program 2.4 (http://www.ltp-program.com) (Anderson and Collingridge, ; Bhagya et al, ; Mahati et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…Recorded video files were coded for behavioral analysis. Data were expressed as the percentage time spent in the open arms [100 × (time in the open arms/total time spent in both arms)] as an index of anxiety‐like behavior and the total number of closed‐arm entries as an index of locomotion (Anuradha et al, ; Bhagya et al, ; Mahati et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…In addition to understanding the deleterious effects of chronic stress on cognition, there is considerable interest in developing novel approaches that may ameliorate these deficits. One such approach is enriched environment (EE), which induces robust plasticity at multiple levels of neural organization (Shors et al, ; Hellemans et al, ; Mora et al, ; Furuie et al, ; Piazza et al, ; Burrows et al, ; Mahati et al, ). Environmental enrichment is exposure to a combination of complex inanimate objects with social interaction (van Praag et al, ; Pang and Hannan, ).…”

mentioning

confidence: 99%

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Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

Bhagya

Srikumar

Veena

et al. 2016

J of Neuroscience Research

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Exposure to prolonged stress results in structural and functional alterations in the hippocampus including reduced long-term potentiation (LTP), neurogenesis, spatial learning and working memory impairments, and enhanced anxiety-like behavior. On the other hand, enriched environment (EE) has beneficial effects on hippocampal structure and function, such as improved memory, increased hippocampal neurogenesis, and progressive synaptic plasticity. It is unclear whether exposure to short-term EE for 10 days can overcome restraint stress-induced cognitive deficits and impaired hippocampal plasticity. Consequently, the present study explored the beneficial effects of short-term EE on chronic stress-induced impaired LTP, working memory, and anxiety-like behavior. Male Wistar rats were subjected to chronic restraint stress (6 hr/day) over a period of 21 days, and then they were exposed to EE (6 hr/day) for 10 days. Restraint stress reduced hippocampal CA1-LTP, increased anxiety-like symptoms in elevated plus maze, and impaired working memory in T-maze task. Remarkably, EE facilitated hippocampal LTP, improved working memory performance, and completely overcame the effect of chronic stress on anxiety behavior. In conclusion, exposure to EE can bring out positive effects on synaptic plasticity in the hippocampus and thereby elicit its beneficial effects on cognitive functions. © 2016 Wiley Periodicals, Inc.

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Section: Methodsmentioning

confidence: 99%

“…Hippocampal slices were prepared as described earlier (Bhagya et al, ; Mahati et al, ). Briefly, the rats from different groups were deeply anesthetized with halothane.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

Bhagya

Srikumar

Veena

et al. 2016

J of Neuroscience Research

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Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Sarkaki

Mard

Bakhtiari

et al. 2022

Intl J of Devlp Neuroscience

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Developmental morphine (MOR) exposure (DME) detrimentally affects the cognitive abilities of the next generation. It is shown that postnatal rearing environments and prenatal conditions effectively impact memory. The present study investigated the effects of DME, postweaning rearing, and sex on spatial learning and memory. At molecular level, we evaluated mRNA levels of brainderived neurotrophic factor, cyclic AMP response element-binding protein (CREB), μ-opioid receptor, and ΔFosB in the hippocampus of male offspring. Female Wistar rats were treated with escalating doses of MOR or saline before mating, gestation, and lactation. On Postnatal Day 22, the male and female pups were divided into 12 groups and raised for 2 months under different conditions: standard, isolated (ISO), or enriched environment. Afterward, the Morris water maze task measured spatial learning and reference memory; rats were then sacrificed to assess hippocampus gene expressions. Results indicated the DME and isolated rearing increased latency to find the hidden platform in male offspring. DME was insignificant in female offspring, whereas rearing environments significantly altered escape latency in both sexes. We also found that the enriched environment upregulated the brain-derived neurotrophic factor mRNA in both saline and MOR groups, whereas it downregulated the mRNA levels of CREB1, μ-opioid receptor, and ΔFosB in the MOR group. In addition, the DME enhanced CREB1, μ-opioid receptor, and ΔFosB gene expression in the MOR + isolated group. Our findings signified the effects of DME, rearing environment, and sex on the spatial learning abilities of offspring. Also, we showed that DME and rearing conditions could manipulate hippocampal neurochemistry. K E Y W O R D S CREB, enriched environment, morphine, sex, ΔFosB, μ-opioid receptor 1 | INTRODUCTION Developmental toxic exposure has long-lasting impacts on the immature nervous system. Opioids are among the most abused drugs during pregnancy, adversely

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Enriched environment ameliorates chronic temporal lobe epilepsy‐induced behavioral hyperexcitability and restores synaptic plasticity in CA3–CA1 synapses in male Wistar rats

Salaka

Nair

Annamalai

et al. 2021

J of Neuroscience Research

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Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies.Pharmacoresistance and comorbidities pose significant challenges to its treatment necessitating the development of non-pharmacological approaches. In an earlier study, exposure to enriched environment (EE) reduced seizure frequency and duration and ameliorated chronic epilepsy-induced depression in rats. However, the cellular basis of beneficial effects of EE remains unknown. Accordingly, in the current study, we evaluated the effects of EE in chronic epilepsy-induced changes in behavioral hyperexcitability, synaptic transmission, synaptophysin (SYN), and calbindin (CB) expression, hippocampal subfield volumes and cell density in male Wistar rats.Epilepsy was induced by lithium-pilocarpine-induced status epilepticus. Chronic epilepsy resulted in behavioral hyperexcitability, decreased basal synaptic transmission, increased paired-pulse facilitation ratio, decreased hippocampal subfields volumes. Moreover, epileptic rats showed decreased synaptophysin and CB expression in the hippocampus. Six weeks post-SE, epileptic rats were exposed to EE for 2 weeks, 6 hr/ day. EE significantly reduced the behavioral hyperexcitability and restored basal synaptic transmission correlating with increased expression of SYN and CB. Our results reaffirm the beneficial effects of EE on behavior in chronic epilepsy and establishes some of the putative cellular mechanisms. Since drug resistance and comorbidities are a major concern in TLE, we propose EE as a potent non-pharmacological treatment modality to mitigate these changes in chronic epilepsy.

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Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity

Cited by 60 publications

References 134 publications

Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

Sex‐specific effects of developmental morphine exposure and rearing environments on hippocampal spatial memory

Enriched environment ameliorates chronic temporal lobe epilepsy‐induced behavioral hyperexcitability and restores synaptic plasticity in CA3–CA1 synapses in male Wistar rats

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