2019
DOI: 10.1007/s11011-018-0370-8
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Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress

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Cited by 14 publications
(10 citation statements)
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“…In another study, an increase in Npas4 expression was detected in the hippocampus of mice subjected to prolonged exposure to an enriched environment early in life [42], and this enriched environment often also caused an enhancement of social behavior in the adult animals [43,44]. Rats with higher hippocampal expression of Npas4 [38] manifest enhanced exploratory behavior.…”
mentioning
confidence: 92%
“…In another study, an increase in Npas4 expression was detected in the hippocampus of mice subjected to prolonged exposure to an enriched environment early in life [42], and this enriched environment often also caused an enhancement of social behavior in the adult animals [43,44]. Rats with higher hippocampal expression of Npas4 [38] manifest enhanced exploratory behavior.…”
mentioning
confidence: 92%
“…Constitutively, active Akt can enhance the myelination of the central nervous system of mice, and as the mouse ages, the increase of myelin sheath continues, leading to the enlargement of the optic nerve and white matter area [ 71 ]. EE plays a positive role in myelination by reversing the decrease of Akt and MBP levels in the forebrain area of chronic fixed stress rats [ 11 ]. mTOR is a well-known Akt substrate.…”
Section: Effect Of Enriched Environment On Myelinationmentioning
confidence: 99%
“…The ERK signaling could active during the rapid growth and thickness of myelin and promote OL differentiation and the initiation of myelination in Erk1/2 KO mice [ 75 ]. It is gratifying that EE promotes myelination and increases myelin thickness by improving ERK mRNA levels in the forebrain of rats with chronic fixation stress [ 11 ].…”
Section: Effect Of Enriched Environment On Myelinationmentioning
confidence: 99%
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“…Therefore, non-pharmacological therapies are emerging [ 32 , 33 ], which can be used concurrently with pharmacotherapy to improve treatment outcomes. Interestingly, these alternative approaches can also be mimicked at the preclinical level by housing the animal in an enriched environment (EE), resembling psychological support [ 34 , 35 , 36 ]. Because individuals characterized by an inherited reduction in SERT expression are more sensitive to both negative and positive environmental stimuli [ 37 ], we hypothesized that SERT knockout rats would benefit most from EE and would display a reduction in depression-like behavior and related neuroplasticity markers when compared to wild-type animals.…”
Section: Introductionmentioning
confidence: 99%