Enriched Gellan Gum hydrogel as visco-supplement

Leone, Gemma; Consumi, Marco; Pepi, Simone; Pardini, Alessio; Bonechi, Claudia; Tamasi, Gabriella; Donati, Alessandro; Lamponi, Stefania; Rossi, Claudio; Magnani, Agnese

doi:10.1016/j.carbpol.2019.115347

Cited by 50 publications

(32 citation statements)

References 34 publications

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“…Therefore, an increase in storage modulus of hydrogel with an increase of Q-CNF content can be attributed to the electrostatic interaction between cationic groups of CNF and phosphate ions of the PBS solution. From the storage modulus, the average mesh size which means the distance between valid crosslinking points could be calculated based on the rubber elasticity theory as described in the literatures [42,43]. After immersion in the PBS solution, the average mesh sizes were 13.6 nm and 12.0 nm for the pure PVP hydrogel and Q-CNF (0.1% consistency)-added PVP hydrogel, respectively.…”

Section: Characteristics Of Cnf-added Pvp Hydrogelmentioning

confidence: 99%

Incorporation of CNF with Different Charge Property into PVP Hydrogel and Its Characteristics

Park

Goo

et al. 2021

Nanomaterials

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Cellulose nanofibril (CNF)-added polyvinylpyrrolidone (PVP) hydrogels were prepared using different types of CNFs and their properties were investigated. CNFs with different morphology and surface charge properties were prepared through quaternization and carboxymethylation pretreatments. The quaternized CNF exhibited the narrow and uniform width, and higher viscoelastic property compared to untreated and carboxymethylated CNF. When CNF was incorporated to PVP hydrogel, gel contents of all hydrogels were similar, irrespective of CNF addition quantity or CNF type. However, the absorptivity of the hydrogels in a swelling medium increased by adding CNF. In particular, the quaternized CNF-added PVP hydrogel exhibited the highest swelling ability. Unlike that of hydrogels with untreated and carboxymethylated CNFs, the storage modulus of PVP hydrogels after swelling significantly increased with an increase in the content of the quaternized CNF. These indicate that a PVP hydrogel with a high absorptivity and storage modulus can be prepared by incorporating the proper type of CNF.

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Section: Characteristics Of Cnf-added Pvp Hydrogelmentioning

confidence: 99%

Incorporation of CNF with Different Charge Property into PVP Hydrogel and Its Characteristics

Park

Goo

et al. 2021

Nanomaterials

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“…These bands are characteristic of the polymer crosslinking by STMP. [ 37–39 ] These bands became weaker as the crosslinked density decreased. As can be seen from the Figure S2 (Supporting Information), the OPO stretching band at 1272 cm −1 and PO bending band at 1020 cm −1 are visible with Bioscaffold‐A and Bioscaffold‐B and it is faintly visible in Bioscaffold‐C.…”

Section: Figurementioning

confidence: 99%

“…The PVA crosslinking reaction with STMP was monitored by Fourier transform infrared (FT-IR) spectroscopy study on the bioscaffold samples. [38][39][40] In this study we used a neat PVA cast film as a control. The FT-IR spectra of bioscaffolds and neat PVA film showed the typical PVA bands corresponding to the hydrogen bonded OH groups at 3290 cm −1 and a CH 2 stretching band at 2930 cm −1 from the alkyl backbone of the polymer.…”

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confidence: 99%

3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair

et al. 2020

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creates a defect that intra-abdominal contents may protrude through. [1] The most common types of hernias are incisional, inguinal, femoral, umbilical and hiatal hernias. [2] Hernia repair for many defects is performed by the surgical implantation of a prosthetic mesh to firmly support and reinforce the damaged abdominal wall and facilitate the healing process (Figure 1A,B). Each year, over 400 000 incisional hernia repair surgeries are performed with a cost of ≈$15 billion in US healthcare expenditures. [3-5] Prosthetic hernia mesh implants are developed using synthetic, biologic, and coated materials. [6,7] Despite their specific advantages, these mesh implants are not very effective in minimizing potential adverse postsurgical complications. [8] Surgical hernia repair with mesh implants mostly fail due to the formation of visceral adhesions, hardening, and shrinking of the mesh after its implantation. Visceral adhesions are fibrous tissues developed from the underlying serosal membrane of stomach, intestine or colon, that attach to the implanted mesh. [9] These adhesions are mainly composed of collagen and fibroblasts that grow on the mesh and adhere to the nearby tissue, nerves and organs. [10] The mesh shrinks as the adhesions grow and scar tissue hardens, thus forming a hard, fibrous mass that may cause chronic pain, bowel obstruction, enteric fistula, infertility, poor quality of life, and failure of the surgical hernia repair. [11-13] To remove the failed hernia mesh, a complicated surgery needs to be performed, wherein the mesh must be peeled off bladder, stomach, intestine, colon, or a major blood vessel, that may adversely affect the clinical outcomes. [14] To minimize adhesions formation, graft contraction, and foreign body reactions, absorbable and biological meshes have been developed. However, these meshes are not significantly effective because of very high hernia recurrence rates. [15-17] Causative factors for adverse complications arising due to surgical mesh implantation are chronic inflammatory responses, poor mesh-tissue integration, rapid degradation of the materials, surface chemistry and topochemical design of the mesh. [18,19] We herein present the development of an intrinsically inflammation modulating 3D-fabricated biomaterial scaffold (bioscaffold) for soft tissue repair and demonstrate its in vivo efficacy in a rat ventral hernia Development of inflammation modulating polymer scaffolds for soft tissue repair with minimal postsurgical complications is a compelling clinical need. However, the current standard of care soft tissue repair meshes for hernia repair is highly inflammatory and initiates a dysregulated inflammatory process causing visceral adhesions and postsurgical complications. Herein, the development of an inflammation modulating biomaterial scaffold (bioscaffold) for soft tissue repair is presented. The bioscaffold design is based on the idea that, if the excess proinflammatory cytokines are sequestered from the site of injury by the surgical implantation of a bioscaffold,...

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“…In this study, we report an advanced pH-responsive system modified by the natural cartilage lubricant, HA [ 34 ], aiming to develop a smart bioengineered drug control release carrier (designated as MOF@HA@PCA) for OA therapy. The MOF@HA-NPs were used to deliver an anti-inflammatory agent protocatechuic acid (PCA), for controlled release in response to acidic environment of OA by using the pH-responsive property of MOF@HA.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

et al. 2020

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Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal − organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA.

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Enriched Gellan Gum hydrogel as visco-supplement

Cited by 50 publications

References 34 publications

Incorporation of CNF with Different Charge Property into PVP Hydrogel and Its Characteristics

Incorporation of CNF with Different Charge Property into PVP Hydrogel and Its Characteristics

3D‐Bioprinted Inflammation Modulating Polymer Scaffolds for Soft Tissue Repair

pH-responsive and hyaluronic acid-functionalized metal–organic frameworks for therapy of osteoarthritis

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