Enrichment of beneficial bacteria in the skin microbiota of bats persisting with white-nose syndrome

Lemieux-Labonté, Virginie; Simard, Anouk; Willis, Craig K. R.; Lapointe, François‐Joseph

doi:10.1186/s40168-017-0334-y

Cited by 208 publications

(62 citation statements)

References 73 publications

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“…Our results join a growing body of evidence suggesting that the microbiota can respond to environmental change. Even though we did not detect dysbiosis in these animals, we recognize that dysbiosis of the microbiota may be monitored as an early warning sign about potential downstream effects on host ecology and health (Bahrndorff, Alemu, Alemneh, & Lund Nielsen, 2016;Cheng et al, 2015;Lemieux-Labonté, Simard, Willis, & Lapointe, 2017;Thomason, Mullen, Belden, May, & Hawley, 2017). We further showed that the relative abundances of some core microbiota members are related to innate immune function.…”

Section: Discussionmentioning

confidence: 67%

“…dysbiosis of the microbiota may be monitored as an early warning sign about potential downstream effects on host ecology and health(Bahrndorff, Alemu, Alemneh, & Lund Nielsen, 2016;Cheng et al, 2015;Lemieux-Labonté, Simard, Willis, & Lapointe, 2017;Thomason, Mullen, Belden, May, & Hawley, 2017). dysbiosis of the microbiota may be monitored as an early warning sign about potential downstream effects on host ecology and health(Bahrndorff, Alemu, Alemneh, & Lund Nielsen, 2016;Cheng et al, 2015;Lemieux-Labonté, Simard, Willis, & Lapointe, 2017;Thomason, Mullen, Belden, May, & Hawley, 2017).…”

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confidence: 99%

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Habitat fragmentation is associated with dietary shifts and microbiota variability in common vampire bats

Ingala

Becker

Holm

et al. 2019

Ecology and Evolution

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Host ecological factors and external environmental factors are known to influence the structure of gut microbial communities, but few studies have examined the impacts of environmental changes on microbiotas in free‐ranging animals. Rapid land‐use change has the potential to shift gut microbial communities in wildlife through exposure to novel bacteria and/or by changing the availability or quality of local food resources. The consequences of such changes to host health and fitness remain unknown and may have important implications for pathogen spillover between humans and wildlife. To better understand the consequences of land‐use change on wildlife microbiotas, we analyzed long‐term dietary trends, gut microbiota composition, and innate immune function in common vampire bats (Desmodus rotundus) in two nearby sites in Belize that vary in landscape structure. We found that vampire bats living in a small forest fragment had more homogenous diets indicative of feeding on livestock and shifts in microbiota heterogeneity, but not overall composition, compared to those living in an intact forest reserve. We also found that irrespective of sampling site, vampire bats which consumed relatively more livestock showed shifts in some core bacteria compared with vampire bats which consumed relatively less livestock. The relative abundance of some core microbiota members was associated with innate immune function, suggesting that future research should consider the role of the host microbiota in immune defense and its relationship to zoonotic infection dynamics. We suggest that subsequent homogenization of diet and habitat loss through livestock rearing in the Neotropics may lead to disruption to the microbiota that could have downstream impacts on host immunity and cross‐species pathogen transmission.

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Section: Discussionmentioning

confidence: 67%

mentioning

confidence: 99%

Habitat fragmentation is associated with dietary shifts and microbiota variability in common vampire bats

Ingala

Becker

Holm

et al. 2019

Ecology and Evolution

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show abstract

“…Principal coordinate analysis (PCoA) was performed to get principal coordinates and visualize from complex, multidimensional data. Observed species, Shannon, Simpson, Chao1, and ACE are used to evaluate the complexity of species diversity . OTUs were further used for genome prediction of microbial communities by PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States) …”

Section: Methodsmentioning

confidence: 99%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

331

277

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Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

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“…Principal coordinates analysis (PCoA) was performed to get principal coordinates and visualize from complex, multidimensional data. Observed-species, Shannon, Simpson, Chao1, and ACE are used to evaluate the complexity of species diversity (54). Operational taxonomic units (OTUs) were further used for genome prediction of microbial communities by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) (55).…”

Section: Gut Microbiota Analysismentioning

confidence: 99%

Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets

et al. 2019

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Obesity increases the risk of developing insulin resistance and diabetes and is a major public health concern. Our previous study shows that dietary β‐hydroxy‐β‐methylbutyrate (HMB) improves lipid metabolism in a pig model. However, it remains unclear whether HMB blocks obesity through gut microbiota. In this study, we found that HMB reduced body weight, alleviated the whitening of brown adipose tissue, and improved insulin resistance in mice fed a high‐fat diet (HFD). High‐throughput pyrosequencing of the 16S rRNA demonstrated that HMB administration significantly reversed the gut microbiota dysbiosis in HFD‐fed mice, including the diversity of gut microbiota and relative abundances of Bacteroidetes and Firmicutes. Moreover, microbiota transplantation from HMB‐treated mice attenuated HFD‐induced lipid metabolic disorders. Furthermore, HFD‐fed mice showed lower short‐chain fatty acids, whereas administration of HMB increased the propionic acid production. Correlation analysis identified a significant correlation between propionic acid production and the relative Bacteroidetes abundance. Sodium propionate treatment also attenuated HFD‐induced lipid metabolic disorders. Collectively, our results indicated that HMB might be used as a probiotic agent to reverse HFD‐induced obesity, and the potential mechanism was associated with reprogramming gut microbiota and metabolism, especially Bacteroidetes‐mediated propionic acid production. In future studies, more efforts should be made to confirm and expand the beneficial effects of HMB to human models.—Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H., Gao, J., Xu, K., Li, T., Yin, Y., Li, F., Yin, J., Kong, X. Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets. FASEB J. 33, 10019–10033 (2019). http://www.fasebj.org

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Enrichment of beneficial bacteria in the skin microbiota of bats persisting with white-nose syndrome

Cited by 208 publications

References 73 publications

Habitat fragmentation is associated with dietary shifts and microbiota variability in common vampire bats

Habitat fragmentation is associated with dietary shifts and microbiota variability in common vampire bats

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Gut microbiota mediates the protective effects of dietary β‐hydroxy‐β‐methylbutyrate (HMB) against obesity induced by high‐fat diets

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