Ensaio clínico randomizado e unicego comparando a aplicação de toxina onabotulínica intradérmica versus intramuscular na região frontal

Quadros, Maurício de; Mylius, Mariana Silveira Ferreira; Sebben, Suelen Raquel; Lodi, A; Mosena, Gabriela; Webber, Analupe

doi:10.5935/scd1984-8773.20181041281

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2023

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“…De Quadros et al . 10 and Jun et al . 11 conducted a split-face study to compare the paralyzing effects of intradermal and intramuscular botulinum toxin injections in the forehead.…”

Section: Resultsmentioning

confidence: 92%

Intramuscular <i>versus</i> intradermal botulinum toxin for forehead wrinkles: a review of side effects and efficacy

Almashali,

Almutairi,

Shadid

2023

Dermatol Reports

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Botulinum toxin type A (BTA) is a neurotoxin used for both cosmetic and non-cosmetic purposes. BTA is commonly administered as an intramuscular injection to treat wrinkles. However, when it comes to treating forehead wrinkles, IM is associated with a greater rate of ptosis. Intradermal injection is currently thought to be a better alternative. We searched PubMed and Google Scholar for research articles published between 1989 and 2023 using the following keywords: “intradermal,” “intramuscular,” “botulinum toxin,” and “forehead wrinkle.” The search yielded three randomized controlled trials and a double-blind, split-face case report on 58 patients. We found that although intradermal and intramuscular injections have symmetrical anti-wrinkle effects, the former results in a lower rate of ptosis and a greater degree of pain.

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“…De Quadros et al . 10 and Jun et al . 11 conducted a split-face study to compare the paralyzing effects of intradermal and intramuscular botulinum toxin injections in the forehead.…”

Section: Resultsmentioning

confidence: 92%