Ent-abietane and ent-pimarane diterpenoids from Croton mubango (Euphorbiaceae)

Unprecedented diterpenoid dimers with soluble epoxide hydrolase inhibitory effect from Euphorbia fischeriana

“…Jolkinolide A is the major component in E. fischeriana produced by diterpene synthases from GGPP. 25,26 The hydration of Δ 11,12 in jolkinolide A could form intermediate i, which could be further oxidized to produce unit B. The hydrolysis of the lactone in jolkinolide A was able to obtain another intermediate ii, which could give iii by ketoenol tautomerism.…”

“…11 However, the occurrence of ent-abietane-type diterpenoids is limited relatively, which were mainly found in Euphorbiaceae plants in recent years. 12,13 Euphorbia fischeriana Steud. is a well-known poisonous plant in the genus Euphorbia belonging to the Euphorbiaceae family.…”

“…11 However, the occurrence of ent -abietane-type diterpenoids is limited relatively, which were mainly found in Euphorbiaceae plants in recent years. 12,13…”

Diterpenoids and C13 Nor-Isoprenoid Identified From the Leaves and Twigs of Croton yanhuii Activating Apoptosis and Pyroptosis

“…The essential oil extracted from the seeds of C. tiglium shows anti-tumor activity ( Niu et al, 2020 ). Previous secondary metabolite investigations of this genus revealed that diterpenoids were the main ingredients ( Xu et al, 2018 ), including clerodane ( Fattorusso et al, 2002 ), tigliane ( Cui et al, 2019 ), kaurane ( Kuo et al, 2013 ), labdane ( Yang et al, 2016 ), and pimarane ( Isyaka et al, 2020 ), which have a wide range of biological activities, such as cytotoxic, anti-inflammatory, and anti-microbial ( Morales et al, 2005 ; Kuo et al, 2007 ; Leite et al, 2017 ). Aside from those abovementioned, alkaloids ( Novello et al, 2016 ), flavonoids ( Cruz et al, 2020 ), phenylpropanoids ( Abreu et al, 2020 ), and other terpenoids like sesquiterpenoids are present in the genus Croton .…”

Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert

“…In our continued search for bioactive compounds from African Croton species (Aldhaher et al, 2017;Isyaka et al, 2020;Langat et al, 2011;Langat et al, 2012;Mulholland et al, 2010) we report the phytochemistry of the stem bark of the Kenyan endangered arborescent C.…”