2020
DOI: 10.3389/fonc.2020.595892
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Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer

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Cited by 28 publications
(18 citation statements)
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“…Наименее изученными структурными элементами энтеральной нервной системы являются глиальные клетки. В настоящее время активно ведутся исследования глии периферической нервной системы [8,9], поскольку она выполняет множество функций, среди которых трофическая, барьерная, защитная и другие. Глиальные элементы нервных ганглиозных сплетений мы исследовали с помощью ИГХ выявления GFAP и белка S100.…”
Section: Discussionunclassified
“…Наименее изученными структурными элементами энтеральной нервной системы являются глиальные клетки. В настоящее время активно ведутся исследования глии периферической нервной системы [8,9], поскольку она выполняет множество функций, среди которых трофическая, барьерная, защитная и другие. Глиальные элементы нервных ганглиозных сплетений мы исследовали с помощью ИГХ выявления GFAP и белка S100.…”
Section: Discussionunclassified
“…An in vivo study has confirmed the tumor-promoting role for EGCs in CRC development [ 78 ]. GFAP+ EGCs were depleted in mouse models of CRC (AOM/DSS and Apc Min/+ ) by injecting either ganciclovir in gfap-tk mice or diphtheria toxin in gfap-CRE iDTR mice.…”
Section: Nervous System Innervation In Colorectal Cancermentioning
confidence: 99%
“…The epithelium of the colon is one of the most frequent sites of tumour initiation while hyperactivation of the WNT signalling pathway has been implicated in the pathogenesis of colorectal cancer [37] . Given the emerging effects of glia-derived WNT ligands on the intestinal epithelium, it is interesting that depletion of GFAP+ EGCs led to a striking reduction of tumour burden in a model of azoxymethane/DSS-induced colon cancer that was much less obvious following depletion of PLP1+ EGCs [38] . Although it is unclear whether glia-derived WNTs are implicated in tumour formation in this model, together, these studies support the central role of the GFAP+ (but not the PLP1+) subpopulation of EGCs in intestinal epithelial health 20 , 21•• , 38• .…”
Section: Enteric Glial Cells Regulate the Health Of Barrier Tissues I...mentioning
confidence: 99%
“…Given the emerging effects of glia-derived WNT ligands on the intestinal epithelium, it is interesting that depletion of GFAP+ EGCs led to a striking reduction of tumour burden in a model of azoxymethane/DSS-induced colon cancer that was much less obvious following depletion of PLP1+ EGCs [38] . Although it is unclear whether glia-derived WNTs are implicated in tumour formation in this model, together, these studies support the central role of the GFAP+ (but not the PLP1+) subpopulation of EGCs in intestinal epithelial health 20 , 21•• , 38• . In further support of a regulatory circuit involving enteric glia and the intestinal epithelium, a functional unit has been previously described in which GFAP+ EGCs produce glia-derived neurotrophic factor (GDNF), in a myeloid differentiation primary response 88 (MYD88)-dependent manner, that acts on rearranged during transfection (RET)-expressing type 3 innate lymphoid cells to secrete the tissue-protective cytokine IL-22 [39] .…”
Section: Enteric Glial Cells Regulate the Health Of Barrier Tissues I...mentioning
confidence: 99%