Enteric neural crest-derived cells: Origin, identification, migration, and differentiation

Young, Heather M.; Newgreen, Don

doi:10.1002/1097-0185(20010101)262:1<1::aid-ar1006>3.0.co;2-2

Cited by 157 publications

(89 citation statements)

References 131 publications

(120 reference statements)

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“…Cardiac neural crest cells originate from a similar head and neck region and form cardiac outflow tract, as well as heart septae and parts of the venricular myocardium (Brown and Baldwin, 2006;Hutson and Kirby, 2007;Jiang et al, 2000). Vagal and sacral neural crest cells migrate from two opposite sides to populate the gastrointestinal system and differentiate into the neurons that innervate the digestive tract (Anderson et al, 2006a;Durbec et al, 1996;Young and Newgreen, 2001). Trunk neural crest cells migrate from the back of the embryo to form sensory and sympathetic neurons, adrenal gland, Schwann cells, and pigment cells of the skin (Hutson and Kirby, 2007;Nagy et al, 2003).…”

Section: Embryonic Migratory Eventsmentioning

confidence: 99%

Cell biology of embryonic migration

Kurosaka¹,

Kashina²

2008

Birth Defects Research Pt C

117

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Cell migration is an evolutionarily conserved mechanism that underlies the development and functioning of uni-and multicellular organisms and takes place in normal and pathogenic processes, including various events of embryogenesis, wound healing, immune response, cancer metastases, and angiogenesis. Despite the differences in the cell types that take part in different migratory events, it is believed that all of these migrations occur by similar molecular mechanisms, whose major components have been functionally conserved in evolution and whose perturbation leads to severe developmental defects. These mechanisms involve intricate cytoskeleton-based molecular machines that can sense the environment, respond to signals, and modulate the entire cell behavior. A big question that has concerned the researchers for decades relates to the coordination of cell migration in situ and its relation to the intracellular aspects of the cell migratory mechanisms. Traditionally, this question has been addressed by researchers that considered the intra-and extracellular mechanisms driving migration in separate sets of studies. As more data accumulate researchers are now able to integrate all of the available information and consider the intracellular mechanisms of cell migration in the context of the developing organisms that contain additional levels of complexity provided by extracellular regulation. This review provides a broad summary of the existing and emerging data in the cell and developmental biology fields regarding cell migration during development.

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Section: Embryonic Migratory Eventsmentioning

confidence: 99%

Cell biology of embryonic migration

Kurosaka¹,

Kashina²

2008

Birth Defects Research Pt C

117

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“…The enteric nervous system (ENS) develops primarily from rhombencephalic neural crest cells that, upon entering the pharynx, proliferate, migrate, and colonize the entire length of the gastrointestinal tract (LeDouarin and Teillet, 1973;Tucker et al, 1986;Burns and LeDouarin, 1998;Young and Newgreen, 2001). Unlike the crest cells that form the sympathetic and spinal sensory ganglia, the enteric crest cells continue to migrate caudally for a protracted period.…”

Section: Introductionmentioning

confidence: 99%

“…In the mouse, enteric crest cells are found in the foregut at E10 and invade the terminal hindgut at E14 (Kapur et al, 1992;Young et al, 1998). Although several studies have advanced our knowledge regarding the role of crest-derived cells in the development of the enteric nervous system (Young and Newgreen, 2001;Young et al, 2002), the spatial relations of pioneering crest cells to each other and to the surrounding gut mesenchymal cells have not been systematically examined as the cells progress throughout the gut.…”

Section: Introductionmentioning

confidence: 99%

“…Extensive analyses have identified critical roles for several ligand-receptor interactions (e.g., GDNF:Ret, ET-3:EtRB) in maintaining the movements and mitotic competence of the enteric crest cell population Newgreen, 2001, Newgreen andYoung, 2002a,b). A key aspect of this process is balancing proliferation of enteric crest cells and the formation of postmitotic neurons and glia.…”

Section: Introductionmentioning

confidence: 99%

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Appearance of neurons and glia with respect to the wavefront during colonization of the avian gut by neural crest cells

Conner

Focke

Noden

et al. 2002

Developmental Dynamics

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The enteric nervous system is formed by neural crest cells that migrate, proliferate, and differentiate into neurons and glia distributed in ganglia along the gastrointestinal tract. In the developing embryo some enteric crest cells cease their caudal movements, whereas others continue to migrate. Subsequently, the enteric neurons form a reticular network of ganglia interconnected by axonal projections. We studied the developing avian gut to characterize the pattern of migration of the crest cells, and the relationship between migration and differentiation. Crest cells at the leading edge of the migratory front appear as strands of cells; isolated individual crest cells are rarely seen. In the foregut and midgut, these strands are located immediately beneath the serosa. In contrast, crest cells entering the colon appear first in the deeper submucosal mesenchyme and later beneath the serosa. As the neural crest wavefront passes caudally, the crest cell cords become highly branched, forming a reticular lattice that presages the mature organization of the enteric nervous system. Neurons and glia first appear within the strands at the advancing wavefront. Later neurons are consistently located at the nodes where branches of the lattice intersect. In the most rostral foregut and in the colon, some neurons initially appear in close association with extrinsic nerve fibers from the vagus and Remak's nerve, respectively. We conclude that crest cells colonize the gut as chains of cells and that, within these chains, both neurons and glia appear close to the wavefront. Developmental Dynamics 226:91-98, 2003.

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“…In E10.5 mice, neural crest-derived cells are present in the rostral midgut, but not in the caudal midgut (Young and Newgreen, 2001). All GFP + neurons examined in E10.5 mice in the current study were present in the rostral midgut and were therefore close to the migratory wavefront.…”

Section: Developmental Neurobiologymentioning

confidence: 99%

The migratory behavior of immature enteric neurons

Hao

Anderson

Kobayashi

et al. 2008

Developmental Neurobiology

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While they are migrating caudally along the developing gut, around 10%-20% of enteric neural crest-derived cells start to express pan-neuronal markers and tyrosine hydroxylase (TH). We used explants of gut from embryonic TH-green fluorescence protein (GFP) mice and time-lapse microscopy to examine whether these immature enteric neurons migrate and their mode of migration. In the gut of E10.5 and E11.5 TH-GFP mice, around 50% of immature enteric neurons (GFP + cells) migrated, with an average speed of around 15 lm/h. This is slower than the speed at which the population of enteric neural crest-derived cells advances along the developing gut, and hence neuronal differentiation seems to slow, but not necessarily halt, the caudal migration of enteric neural crest cells. Most migrating immature enteric neurons migrated caudally by extending a long-leading process followed by translocation of the cell body. This mode of migration is different from that of non-neuronal enteric neural crestderived cells and neural crest cells in other locations, but resembles that of migrating neurons in many regions of the developing central nervous system (CNS). In migrating immature enteric neurons, a swelling often preceded the movement of the nucleus in the direction of the leading process. However, the centrosomal marker, pericentrin, was not localized to either the leading process or swelling. This seems to be the first detailed report of neuronal migration in the developing mammalian peripheral nervous system. ' 2008 Wiley Periodicals, Inc. Develop Neurobiol 69: 22-35, 2009

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Enteric neural crest-derived cells: Origin, identification, migration, and differentiation

Cited by 157 publications

References 131 publications

Cell biology of embryonic migration

Cell biology of embryonic migration

Appearance of neurons and glia with respect to the wavefront during colonization of the avian gut by neural crest cells

The migratory behavior of immature enteric neurons

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