Enterococci: An Important Nosocomial Pathogen

Bhardwaj, Sonia Bhonchal

doi:10.5772/intechopen.90550

Cited by 12 publications

(7 citation statements)

References 49 publications

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“…In recent years, among the MDR bacteria responsible for nosocomial infections, the Enterococcus spp. received particular attention due to its ability to cause urinary tract infection, bacteremia, and infective endocarditis [ 8 , 9 ]. Enterococci are Gram-positive, opportunistic microorganisms that normally inhabit the human gastrointestinal tract [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy

et al. 2021

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Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent years, among the multidrug-resistant microorganisms responsible for nosocomial infections, the Enterococcus species have received much attention. Indeed, Enterococcus have peculiar skills in their ability to acquire resistance genes and to cause severe diseases, such as endocarditis. This study showed the prevalence and antimicrobial resistance rate of Enterococcus spp. isolated from clinical samples, from January 2015 to December 2019 at the University Hospital “San Giovanni di Dio e Ruggi d’Aragona” in Salerno, Italy. A total of 3236 isolates of Enterococcus faecalis (82.2%) and Enterococcus faecium (17.8%) were collected from urine cultures, blood cultures, catheters, respiratory tract, and other samples. Bacterial identification and antibiotic susceptibility were performed with VITEK 2. E. faecium showed a high resistance rate against ampicillin (84.5%), ampicillin/sulbactam (82.7%), and imipenem (86.7%), while E. faecalis showed the highest resistance rate against gentamicin and streptomycin high level, but both were highly sensitive to such antibiotics as tigecycline and vancomycin. Studies of surveillance are an important tool to detect changes in the resistance profiles of the main pathogens. These antimicrobial susceptibility patterns are necessary to improve the empirical treatment guideline of infections.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy

et al. 2021

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“…Enterococci are the second most frequent cause of bacteremia, nosocomial urinary tract infection, infective endocarditis, gastrointestinal, intra-abdominal, pelvic, and oral infections. Enterococcus faecalis has become an important microorganism in public health because of multidrug resistance in VRE [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Antitumoral Activity of Biohybrids Based on Turmeric and Silver/Silver Chloride Nanoparticles

et al. 2021

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The phyto-development of nanomaterials is one of the main challenges for scientists today, as it offers unusual properties and multifunctionality. The originality of our paper lies in the study of new materials based on biomimicking lipid bilayers loaded with chlorophyll, chitosan, and turmeric-generated nano-silver/silver chloride particles. These materials showed a good free radical scavenging capacity between 76.25 and 93.26% (in vitro tested through chemiluminescence method) and a good antimicrobial activity against Enterococcus faecalis bacterium (IZ > 10 mm). The anticancer activity of our developed bio-based materials was investigated against two cancer cell lines (human colorectal adenocarcinoma cells HT-29, and human liver carcinoma cells HepG2) and compared to one healthy cell line (human fibroblast BJ cell line). Cell viability was evaluated for all prepared materials after a 24 h treatment and was used to select the biohybrid with the highest therapeutic index (TI); additionally, the hemolytic activity of the samples was also evaluated. Finally, we investigated the morphological changes induced by the developed materials against the cell lines studied. Biophysical studies on these materials were done by correlating UV–Vis and FTIR absorption spectroscopy, with XRD, SANS, and SAXS methods, and with information provided by microscopic techniques (AFM, SEM/EDS). In conclusion, these “green” developed hybrid systems are an important alternative in cancer treatment, and against health problems associated with drug-resistant infections.

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“… 37 Similarly, the Enterococcus genus has also been found to be predominant in COVID-19 patients, signifying its potential involvement in the disease process. 38 These findings emphasize that microbial composition dysbiosis was more prevalent in the Delta infected patients and its mortality outcomes.…”

Section: Discussionmentioning

confidence: 86%

Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity

Devi,

Kumari,

Yadav

et al. 2023

iScience

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Enterococci: An Important Nosocomial Pathogen

Cited by 12 publications

References 49 publications

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy

Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy

Characterization and Antitumoral Activity of Biohybrids Based on Turmeric and Silver/Silver Chloride Nanoparticles

Longitudinal study across SARS-CoV-2 variants identifies transcriptionally active microbes (TAMs) associated with Delta severity

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