Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells

Shalev, Y.; Hadaya, Oren; Bransi, R.; Landau, S.; Azaizeh, Hassan; Muklada, H.; Glasser, Tzach; Roth, Zvi; Deutch-Traubman, Tova; Haj-Zaroubi, Manal; Argov-Argaman, Nurit

doi:10.1016/j.heliyon.2022.e09025

Cited by 8 publications

(3 citation statements)

References 76 publications

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“…[ 103 ] Mammary epithelial cells exposed to extracts of Pistacia lentiscus containing ethyl gallate, gallic acid, myricetin, have improved mitochondrial activity and greater secretion of protein and fat; however, isolated polyphenols were not as effective as exposure to the complete plant extract suggesting additive or even synergistic effect on milk production traits. [ 104 ] To our knowledge, there is no information regarding the use of lentisk in breastfeeding women.…”

Section: Resultsmentioning

confidence: 99%

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

Kelleher,

Burkinshaw,

Kuyooro

2024

Molecular Nutrition Food Res

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Botanicals and herbal supplements contain a diverse array of polyphenols that may affect mammary gland function and promote galactagogue activity. This scoping review is conducted to identify scientific literature elucidating how polyphenols affect mammary gland biology and cellular mechanisms critical for lactation. A literature search of PubMed and Medline reviews relevant studies in dairy animals, rodent models, and cultured mammary epithelial cells that are published from January 2010 until July 2023, to ascertain effects of polyphenols on mechanisms regulating milk production and composition. The PRISMA‐ScR (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses for Scoping Review) strategy is applied and 80 studies on polyphenols and their implications on milk production and composition are included in this review. Limited information delineating effects of polyphenols on the molecular pathways that affect lactation are found, although available information suggests modulation of Stat5 signaling/differentiation, Stat3 signaling/remodeling, mTOR and insulin signaling/energy production, and nuclear factor kappa beta (NFκβ) signaling/oxidative stress and inflammation may play roles. A profound lack of mechanistic information underscores the critical need for further research to understand the impact of botanical supplements and polyphenols on milk production and composition in humans to establish maternal nutritional guidelines to support lactation and breastfeeding goals.

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Section: Resultsmentioning

confidence: 99%

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

Kelleher,

Burkinshaw,

Kuyooro

2024

Molecular Nutrition Food Res

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“…Thirteen triterpenoids were isolated from P. lentiscus resin; four of the compounds exhibited moderate inhibitory effect against NO production inmurine macrophage cells (RAW 264.7) (95). Sixteen tirucallane triterpenoids from leaves and stems of P. lentiscus were assessed for NO inhibitory potential; four of the compounds exhibited stronger inhibitory activities than positive control dexamethasone (175).…”

Section: Pharmacological Usesmentioning

confidence: 99%

A Review of the Phytochemical Properties and Pharmacological Uses of the Genus Pistacia L. (Anacardiaceae)

Crutcher,

Schroeder,

Wagner

et al. 2023

Infarma

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O gênero Pistacia pertence à família Anacardiaceae e é composto por cerca de vinte espécies, sendo as mais comuns P. atlantica, P. chinensis, P. integerrima, P. khinjuk, P. lentiscus, P. terebinthus, P. vera e P. weinmanifolia. Várias partes dessas diferentes espécies são ricas em importantes compostos fitoquímicos, incluindo constituintes de óleo essencial, monoterpenoides, sesquiterpenoides, diterpenoides, triterpenoides, tetraterpenoides, flavonoides, compostos fenólicos, taninos, ácidos graxos, esteroides e outros compostos. A literatura publicada revelou muitos usos farmacológicos para várias espécies. As partes das plantas mais estudadas quanto à composição química foram as folhas, com 36%, seguidas dos frutos, com 19 %. Esses usos incluem efeitos antioxidantes, hepatoproteção, efeitos anti-inflamatórios, efeitos antimicrobianos, propriedades cicatrizantes/analgésicas, propriedades anticancerígenas, digestivo e tratamento de várias condições crônicas. Após a investigação completa sobre este gênero, as propriedades fitoquímicas e usos farmacológicos de nove espécies de Pistacia foram descritas nesta abrangente revisão da literatura.

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“…Roza et al (2020) mengatakan bahwa pemberian daun singkong meningkatkan produksi susu kerbau karena kandungan tanin terkondensasi dalam daun singkong yang berperan dalam membentuk tannin-protein kompleks dan meningkatkan protein by pass di dalam rumen, sehingga daun singkong sebagai sumber protein tambahan dapat meningkatkan produksi susu dan komposisi susu. Sementara Shalev et al( 2022) mengatakan bahwa kandungan fenolik pada suatu ekstrak berpengaruh terhadap peningkatan produksi dan metabolisme sel-sel kelenjar susu.…”

Section: Pembahasanunclassified

Histological of Mice Mammal Glands That Supplementation With Infuse Water of Manihot Esculenta Leaves

Warmadewi,

Rai Suarni,

Sudatri

2023

SIMBIOSIS

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Phytoestrogens are plant compounds whose structure and properties are similar to estrogens. Flavonoids are one of the phytoestrogen compounds and cassava leaves are known to contain flavonoid compounds. This study was conducted to determine the effect of steeping cassava leaves on the histology of the mammary glands of female mice. This study used a completely randomized design (CRD) which consisted of 4 treatments and 6 replications. The treatment consisted of K0 as a control given 0.5 mL/bb/day of distilled water, P1 given 0.5 mL of cassava leaves steeped with a concentration of 7%, P2 given 0.5 mL of cassava leaves steeped at a concentration of 9%, P3 which was given a decoction of cassava leaves 0.5 mL with a concentration of 11% for 21 days. On the 22nd day, surgery was performed, then the mammary glands of the mice were taken to make histological incisions. Histological incisions of the mice's mammary glands were made using the paraffin method and hematoxylyn-eosin staining and observed under a microscope with 100x magnification with the help of optilab and the image raster program. Parameters observed included the number of mammary gland alveoli, the number of mammary gland ducts, and the diameter of the mammary gland ducts. The data obtained was analyzed statistically with the SPSS series 23 for Windows program. If the results of the analysis show a significant difference, then continue with the Duncan test. The results showed that steeping cassava leaves significantly increased the average number of alveoli, number of ducts and duct diameter of the mammary glands of female mice. The most influential dose of steeped cassava leaves was the dose of 9 g/Kg BW of female mice.

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Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells

Cited by 8 publications

References 76 publications

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

Polyphenols and Lactation: Molecular Evidence to Support the Use of Botanical Galactagogues

A Review of the Phytochemical Properties and Pharmacological Uses of the Genus Pistacia L. (Anacardiaceae)

Histological of Mice Mammal Glands That Supplementation With Infuse Water of Manihot Esculenta Leaves

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