Entrapment of drugs in dental calculus – Detection validation based on test results from post-mortem investigations

Sørensen, Lambert K.; Hasselstrøm, Jørgen B.; Larsen, Line Staun; Bindslev, Dorthe Arenholt

doi:10.1016/j.forsciint.2020.110647

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…This is believed to be due to individual characteristics and genetic polymorphisms related to the activity of the CYP1A2 isoform of the P-450 cytochrome, involved in substance metabolism [74,84]. Caffeine presence can also be assessed by analyzing urine, cerebrospinal fluid, saliva, bile, dental calculus, and tissue fragments, such as kidney or spleen [74,81,[95][96][97][98]. Additionally, when analyzing cases of deaths due to energy drink overdose, it is crucial to collect witness reports regarding the victim's symptoms and analyze the scene of the incident to search for elements indicating intensive consumption, such as empty cans of drinks.…”

Section: State Of Knowledgementioning

confidence: 99%

Medical and forensic aspects of energy drinks and caffeine shots

Kycler,

Rzepczyk,

Markowska

et al. 2024

Med Og Nauk Zdr.

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Introduction andObjective. The number of users of energy drinks and caffeine shots worldwide is very high and varies depending on the age group. In many countries, legislative measures have been taken to restrict access to these products for minors. The main ingredient in energy boosters is caffeine which is responsible for the stimulating properties of these products. Other substances, such as guarana, taurine, vitamins, and simple sugars, are also included in their composition. The aim of the study is to investigate the impact of these products on the body, and their medical and forensic aspects. Review Methods. A literature review was conducted using PubMed, Medline, Google Scholar, and information from legal documents and product labels available on the market. Brief description of the state of knowledge. The use of high-caffeine products is associated with a negative impact on various systems in the human body, with cardiovascular issues being the most commonly observed. Based on available literature, it can be speculated that children are most vulnerable to the harmful effects of these substances. Another concern related to energy drinks and caffeine shots is their interaction with many medications and other substances. There have been cases reported of overdosing on energy drinks, suicide attempts, and deaths, as a result. In medico-legal diagnostics, toxicological examinations regarding caffeine levels in the blood and appropriate differential diagnostics are crucial. Summary. The consumption of energy drinks and caffeine shots may pose a threat to health. Further analyses of the broad impact of these products on the human body, with special consideration for children, are needed.

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Section: State Of Knowledgementioning

confidence: 99%

Medical and forensic aspects of energy drinks and caffeine shots

Kycler,

Rzepczyk,

Markowska

et al. 2024

Med Og Nauk Zdr.

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“…Therefore, it should always be cautiously assumed that plants with a medical use identified in calculus were indeed used as ‘medication’ even if the disorder they were taken for is visible on the skeleton. Before closing, we should mention that recent work adopting ultra-high-performance liquid chromatography-tandem mass spectrometry using pneumatically assisted electrospray ionization (UHPLC-ESI-MS/MS) on modern samples begins to reveal the potential of using dental calculus to detect the consumption of drugs and medication in the form of chemical compounds ( Sørensen et al, 2021 ). This is a promising approach though still at an early stage.…”

Section: Combining Osteoarchaeological Parameters With Dental Calculusmentioning

confidence: 99%

Beyond dirty teeth: Integrating dental calculus studies with osteoarchaeological parameters

Radini

Nikita

2023

Quaternary International

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“…Age and sex can be estimated by analyzing the dentin. Some authors have identified drugs, proteins, lipids, and carbohydrates in the tartar collected from corpses or from a living person, which can point to a certain population group through information related to socio-economic status, occupation, diet, dental, or systemic diseases [ 15 , 16 ]. However, the existing technique can be exhausting and complicated in a larger scale expertise, which requires a much larger number of forensic odontostomatological identifications.…”

Section: Literature Reviewmentioning

confidence: 99%

Enhancing the Evidence with Algorithms: How Artificial Intelligence Is Transforming Forensic Medicine

Piraianu,

Fulga,

Musat

et al. 2023

Diagnostics

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Background: The integration of artificial intelligence (AI) into various fields has ushered in a new era of multidisciplinary progress. Defined as the ability of a system to interpret external data, learn from it, and adapt to specific tasks, AI is poised to revolutionize the world. In forensic medicine and pathology, algorithms play a crucial role in data analysis, pattern recognition, anomaly identification, and decision making. This review explores the diverse applications of AI in forensic medicine, encompassing fields such as forensic identification, ballistics, traumatic injuries, postmortem interval estimation, forensic toxicology, and more. Results: A thorough review of 113 articles revealed a subset of 32 papers directly relevant to the research, covering a wide range of applications. These included forensic identification, ballistics and additional factors of shooting, traumatic injuries, post-mortem interval estimation, forensic toxicology, sexual assaults/rape, crime scene reconstruction, virtual autopsy, and medical act quality evaluation. The studies demonstrated the feasibility and advantages of employing AI technology in various facets of forensic medicine and pathology. Conclusions: The integration of AI in forensic medicine and pathology offers promising prospects for improving accuracy and efficiency in medico-legal practices. From forensic identification to post-mortem interval estimation, AI algorithms have shown the potential to reduce human subjectivity, mitigate errors, and provide cost-effective solutions. While challenges surrounding ethical considerations, data security, and algorithmic correctness persist, continued research and technological advancements hold the key to realizing the full potential of AI in forensic applications. As the field of AI continues to evolve, it is poised to play an increasingly pivotal role in the future of forensic medicine and pathology.

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Entrapment of drugs in dental calculus – Detection validation based on test results from post-mortem investigations

Cited by 12 publications

References 34 publications

Medical and forensic aspects of energy drinks and caffeine shots

Medical and forensic aspects of energy drinks and caffeine shots

Beyond dirty teeth: Integrating dental calculus studies with osteoarchaeological parameters

Enhancing the Evidence with Algorithms: How Artificial Intelligence Is Transforming Forensic Medicine

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