This paper reports a numerical study of mixed convection heat transfer with entropy generation in a vented complex shape cavity filled with MWCNT−MgO (15:85 vol %) /water hybrid nanofluid. A hot source is placed at the mid potion of the inclined plate of the enclosure, while the rest of the rigid walls are adiabatic. A thermo-dependent correlations proposed by [12] for the dynamic viscosity and the thermal conductivity, especially developed for the considered fluid, are used. After validation of the model, the analysis has been done for a Reynolds numbers ranging from 10 to 600 and total nanoparticles volume fraction ranging from 0.0 to 0.02 using the finite volume method. The predicted results of streamlines, isotherms, isentropic lines, average Nusselt number, average entropy generation and average Bejan number are the main focus of interest in the present paper.