Environment-sensitive hydrogels for drug delivery

Qiu, Yong; Park, Kinam

doi:10.1016/j.addr.2012.09.024

Cited by 874 publications

(547 citation statements)

References 105 publications

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“…Imitating this behavior of nature archetypes, synthetic systems attain adaptability to environmental changes (e.g., artifi cial irises [ 1 ] adjust to the light intensity) as well as possibility to interact with the environment mechanically [ 2,3 ] or chemically. [ 4,5 ] Mimicking the mechanics of the plant cell swelling process in osmosis, the shape of soft objects can be tailored by using stimuli-responsive polymers. [ 6 ] In hydrogel composites, [ 7 ] a reversible shape transformation including elongation, twisting, or folding [ 8 ] is achieved upon external chemical or thermal stimulation rendering these biomimetic devices to be mechanically active.…”

Section: Doi: 101002/adma201503696mentioning

confidence: 99%

Biomimetic Microelectronics for Regenerative Neuronal Cuff Implants

et al. 2015

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Section: Doi: 101002/adma201503696mentioning

confidence: 99%

Biomimetic Microelectronics for Regenerative Neuronal Cuff Implants

et al. 2015

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“…Both systems will allow for point-of-care continuous monitoring and delivery. Stimulusresponsive polymers are being investigated for disease site drug delivery and have been reviewed extensively 67,68 . A coupling of this knowledge base and that of the advanced fabrication of polymers, and specifically hydrogel microneedles will see the growth of SRM's.…”

Section: Emergence Of Smart Biofunctional Microneedles With Combined mentioning

confidence: 99%

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

Cahill

O’Cearbhaill

2015

Bioconjugate Chem.

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Microneedles have recently been adopted for use as a painless and safe method of transdermal therapeutic delivery through physically permeating the stratum corneum. While microneedles create pathways to introduce drugs, they can also act as conduits for biosignal sensing. Here, we explore the development of microneedles as both biosensing and drug delivery platforms. Microneedle sensors are being developed for continuous monitoring of biopotentials and bioanalytes through the use of conductive and electrochemically reactive biomaterials. The range of therapeutics being delivered through microneedle devices has diversified, while novel bioabsorbable microneedles are undergoing first-in-human clinical studies. We foresee that future microneedle platform development will focus on the incorporation of biofunctional materials, designed to deliver therapeutics in a stimulus responsive fashion. Biofunctional microneedle patches will require improved methods of attaching to and conforming to epithelial tissues in dynamic environments for longer periods of time and thus present an assortment of new design challenges. Through the evolution of biomaterial development and microneedle design, biofunctional microneedles are proposed as a next generation of stimulus responsive drug delivery systems.

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“…반응함으로써 물질의 물리/ 화학적 특성이 제어되는 장점이 있으며, 이로 인하여 조직 공학 [1][2][3], 약물 전달 시스템 [4][5][6][7], 바 이오 센서 [4,[8][9][10]] 등 정밀함을 필요로 하는 의료 및 재료산업 분야에 널리 응용되고 있다.…”

Section: 서 론 외부 자극에 응답하는 입자는 미세한 외부 환경의 변화에unclassified

Synthesis of Shape Reconfigurable Janus Particles by External pH Stimuli

Eom¹,

Kim²,

Kang

et al. 2014

Clean Technology

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: This study presents a micromolding for the synthesis of Janus particles with reconfigurable shape by pH stimuli. First, we use acrylic acid (AA) as pH responsive monomer in the hydrophilic part and trimethylolpropane triacylate (TMPTA) in the hydrophobic part, respectively. The change of acidity in solvent induces the swelling of hydrophilic part in the Janus particles. The pH-responsive Janus particles show different swelling ratio of hydrophilic part in according to composition of acrylic acid in diverse range (0-70% v/v) and pH (3-11). As the concentration of acrylic acid in the hydrophilic part and environmental pH increase, the hydrophilic part in the Janus particles is proportionally swelled. Second, we fabricate novel type of Janus particles with two different hydrophilicities. As a proof of concept, we have applied acrylic acid (AA) and 2-(dimethylamino)ethyl methacrylate (DAEMA) into each part because the monomers provide reverse responsive activity. As expected, these Janus particles show different shape anisotropies with reconfigurable property in accordance with the polarity of each part at same acidity of environmental solvent. We envision that the stimuli responsive Janus particles have a wide application from fundamental science to diagnostic apparatus.

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Environment-sensitive hydrogels for drug delivery

Cited by 874 publications

References 105 publications

Biomimetic Microelectronics for Regenerative Neuronal Cuff Implants

Biomimetic Microelectronics for Regenerative Neuronal Cuff Implants

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

Synthesis of Shape Reconfigurable Janus Particles by External pH Stimuli

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