Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988–1994 and 1999–2004

López, David S.; Wulaningsih, Wahyu; Tsilidis, Konstantinos K.; Baillargeon, Jacques; Williams, SB; Urban, Randall J.; Rohrmann, Sabine

doi:10.1007/s42000-020-00179-w

Cited by 6 publications

(5 citation statements)

References 49 publications

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“…The EWAS was proposed to identify multiple environmental factors (173 to 266 nutritional and lifestyle factors) associated with complex diseases (e.g. deficiency testosterone 67 , peripheral arterial disease 68 ) by borrowing the GWAS methodology, including a data-driven analysis. To our knowledge, the present study was the first to examine the 3D facial morphology based on multiple environmental factors (i.e.…”

Section: Discussionmentioning

confidence: 99%

Influence of the nutritional status on facial morphology in young Japanese women

Tanikawa

Kurata²,

Tanizaki³

et al. 2022

Sci Rep

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Evidence regarding the possible influence of nutritional status on the facial morphology has thus far been insufficient. We examined whether or not the physical body compositions and dietary behaviors were correlated with any morphological characteristics of the face. One hundred and fifteen young Japanese women participated. Variables representing the dietary behaviors were extracted from self-reported survey data, and corresponding three-dimensional (3D) facial images and body compositions were examined. Multivariate analyses identified significant relationships between the nutritional status and facial topography (p < 0.05). The clustering method revealed the existence of three dietary condition patterns (“balanced diet”, “high-calorie-diet” with obesity tendency, and “imbalanced low-calorie-diet” with sarcopenic obesity tendency). Among these three patterns, a round face (increased facial width; analysis of variance [ANOVA], p < 0.05) was observed in the high-calorie-diet pattern, while the imbalanced low-calorie-diet pattern showed a more masculine face (increased face height, decreased eye height, increased non-allometric sexual shape differences; ANOVA, p < 0.05), thus suggesting the possibility of sex-hormonal influences. In summary, the body composition and dietary behaviors were found to influence the facial morphology, and potential biological influences were discussed.

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Section: Discussionmentioning

confidence: 99%

Influence of the nutritional status on facial morphology in young Japanese women

Tanikawa

Kurata²,

Tanizaki³

et al. 2022

Sci Rep

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“…31 Frequently-studied health outcomes were type 2 diabetes, 30,32,33 obesity, 34,35 and blood pressure. 36,37 Other outcomes included liver enzymes, 38 mental and social well-being, 39 testosterone deficiency, 40 diabetic retinopathy, 41 multiple sclerosis, 42 peripheral arterial disease, 43 and cardiovascular disease. 44 However, no studies have simultaneously and comprehensively examined environmental chemical exposures associated with cognitive decline in older adults.…”

Section: Introductionmentioning

confidence: 99%

Environment-Wide Association Study of Cognitive Function in U.S. Older Adults using the NHANES Data

Jang,

Lee,

Nguyen

et al. 2024

Preprint

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Neurodegenerative diseases pose increasing challenges to global aging populations. Cognitive decline in older adults is an initial indicator of neurodegenerative diseases, yet comprehensive research on environmental chemical exposures related to cognitive decline is limited. This study uses Environment-Wide Association Study (EWAS) framework to investigate associations of environmental chemicals with cognitive function in individuals aged ≥60 years. We used the Digit Symbol Substitution Test (DSST) scores (lower scores indicate cognitive decline) and chemical biomarker data of the U.S. National Health and Nutrition Examination Survey (NHANES) spanning four cycles (1999-2000, 2001-2002, 2011-2012, 2013-2014). We conducted multiple survey-weighted regression to identify biomarkers associated with DSST scores, penalized logit regression to estimate odds ratio (OR) of cognitive decline with identified biomarkers, and correlation network analyses to examine relationships among identified biomarkers and cognitive decline. After correction for multiple comparisons, 27 out of 173 biomarkers having a ≥10% detection rate were associated with DSST scores (q-value <0.05). Among them, increased odds of cognitive decline were associated with elevated levels of blood lead (Pb) (OR = 1.12, 95% CI: 1.01,1.42), blood 1,4-dichlorobenzene (1,4-DCB) (OR = 1.34, 95% CI: 1.17, 1.54), and urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) (OR = 1.34, 95% CI: 1.10, 1.62). Correlation network showed biomarkers that potentially impact cognitive decline upon related health conditions, such as stroke. In conclusion, leveraging the EWAS framework enables us to identify chemical biomarkers that were not previously discovered from traditional approaches of examining a small number of chemicals at a time. While our findings provide foundation for further research, longitudinal studies are warranted to elucidate causal relationships.

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“…A negative correlation between serum phosphorus and testosterone (T) level was also found in older men [16]. In addition, dietary phosphate intake is inversely associated with T de ciency in humans [17] and with IR in mice [18]. However, to the best of our knowledge, only one previous study reported a negative correlation relationship between serum phosphorus and IR in women with PCOS, and most of these patients were obese [19].…”

Section: Introductionmentioning

confidence: 99%

Associations of Serum Phosphorus Concentrations with Insulin Resistance and Hyperandrogenemia in Normal Weight Women with Polycystic Ovary Syndrome

Zhang

et al. 2022

Preprint

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Purpose: Serum phosphorus is reported to be associated with insulin resistance (IR) and testosterone in many populations. However, studies exploring the role of serum phosphorus in polycystic ovary syndrome (PCOS) patients are rare. Thus, we aimed to investigate the associations of serum phosphorus concentrations with IR and hyperandrogenemia (HA) in women with PCOS.Methods: This was a secondary analysis of a multicenter and large-sample clinical trial including 1000 PCOS subjects diagnosed by the modified Rotterdam criteria. A total of 508 normal-weight PCOS patients with available serum phosphorus data were enrolled in the present study. Serum phosphorus, metabolic indices, and total testosterone (TT) concentration were measured. IR status was defined by a homeostasis model assessment of insulin resistance (HOMA‐IR) ≥ 2.69, and HA status was defined as a TT level ≥ 1.67 nmol/L. Multivariable linear regression and logistic regression models were used to evaluate the associations of serum phosphorus with IR and HA.Results: Multiple linear regression analysis showed that the serum phosphorus concentration was inversely correlated with fasting plasma glucose (FPG), fasting insulin (FIN), HOMA‐IR, and TT (P trend < 0.05 for all) after adjusting for confounding factors. Logistic regression showed that the serum phosphorus concentration was negatively correlated with IR and HA status. The multivariable-adjusted odds ratios with 95% confidence intervals for IR and HA status for the lowest vs. the highest quartiles of serum phosphorus were 2.26 (1.17-4.35, P trend = 0.009) and 2.58 (1.48–4.51, P trend = 0.002), respectively. Conclusion: Our results demonstrated that lower serum phosphorus concentrations were associated with higher risk of IR and worsened HA in normal-weight women with PCOS.

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Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988–1994 and 1999–2004

Cited by 6 publications

References 49 publications

Influence of the nutritional status on facial morphology in young Japanese women

Influence of the nutritional status on facial morphology in young Japanese women

Environment-Wide Association Study of Cognitive Function in U.S. Older Adults using the NHANES Data

Associations of Serum Phosphorus Concentrations with Insulin Resistance and Hyperandrogenemia in Normal Weight Women with Polycystic Ovary Syndrome

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