Environmental and occupational determinants of lung cancer

Shankar, Abhishek; Dubey, Anusha; Saini, Deepak; Singh, Mayank; Prasad, Chandra Prakash; Roy, S. C. Dutta; Bharati, Sachidanand Jee; Minakshi, Rinki; Singh, Navneet; Seth, Tulika; Khanna, M.; Sethi, Niharika; Kumar, Sunil; Sirohi, Bhawna; Mohan, Anant; Guleria, Randeep; Rath, Goura Kishor

doi:10.21037/tlcr.2019.03.05

Cited by 107 publications

(76 citation statements)

References 122 publications

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“…Lung cancer is preventable and awareness regarding risk factors (i.e. active and passive smoking, a variety of occupational agents and indoor and outdoor air pollution) along with behavior modifications are key strategies in lung cancer prevention [12]. The COVID-19 pandemic has adversely affected all these activities, but awareness can be continued using the various platforms for online education.…”

Section: Challenges In Lung Cancer Awarenessmentioning

confidence: 99%

Lung Cancer Management Challenges Amidst COVID-19 Pandemic: Hope Lives Here

et al. 2020

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Section: Challenges In Lung Cancer Awarenessmentioning

confidence: 99%

Lung Cancer Management Challenges Amidst COVID-19 Pandemic: Hope Lives Here

et al. 2020

Self Cite

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“…It is responsible for the highest number of either new cases or deaths, approximately 11.6% and 18.4% of the total, respectively [15]. So far, while smoking or consumption of tobacco products is the main cause of lung cancer that accounts for about 90% of cases; other risk factors, including environmental and occupational exposure, might contribute to the etiology of lung cancer [16,17]. As mentioned above, PM2.5 easily penetrates deeper into the lungs or bronchi alveoli and persistently remains in these areas due to its extremely small size.…”

Section: Epidemiological Evidences Of Pm25-associated Lung Cancermentioning

confidence: 99%

The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Lee

et al. 2020

Cancers

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Cancer is one of the leading causes of premature death and overall death in the world. On the other hand, fine particulate matter, which is less than 2.5 microns in aerodynamic diameter, is a global health problem due to its small diameter but high toxicity. Accumulating evidence has demonstrated the positive associations between this pollutant with both lung and non-lung cancer processes. However, the underlying mechanisms are yet to be elucidated. The present review summarizes and analyzes the most recent findings on the relationship between fine particulate matter and various types of cancer along with the oxidative stress mechanisms as its possible carcinogenic mechanisms. Also, promising antioxidant therapies against cancer induced by this poison factor are discussed.

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“…Moreover, the cancer of the lung and bronchus accounts for 27% of all cancer deaths and is the most common cause of cancer death in both sexes, men and women [1][2]. Lung cancer is a multifactorial disease with many risk factors [3]. Genetic, environmental and occupational factors, particularly, exposure to tobacco, non-ionizing and ionizing radiation, chemicals (asbestos, dioxins, metals, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Genetic, environmental and occupational factors, particularly, exposure to tobacco, non-ionizing and ionizing radiation, chemicals (asbestos, dioxins, metals, etc. ), and industrial emissions are all high risk factors in lung cancer development [3]. Of all lung cancer types, non-small cell lung cancer (NSCLC) accounts for the highest number of lung cancer death [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic Effects of Xanthohumol and Its Combination with Cisplatin on Human Metastatic Lung Cancer H1299 Cells

Long¹,

Parks

Pacurari

et al. 2019

JAMMR

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Aims: Non-small cell lung cancer (NSCLC) accounts for high lung cancer death that is mostly associated with advanced disease stage at diagnosis and resistance to chemotherapy. In the present study, we investigated whether xanthohumol, a prenylated flavonoid of hop plant, induces metastatic lung cancer H1299 cell death, and whether in combination with cisplatin there are additive effects. Methodology: H1299 cells were grown and treated with xanthohumol (6.25, 12.5, or 25 µM), cisplatin (12.5, 25, or 50 µM) and the combination of cisplatin and xanthohumol for 24 h. Cell viability, cell morphology, chromatin condensation, ɣH2AX, cPARP-1, capsase-3, p21WAF1/CIP1 and p14ARF genes were analyzed. Results: Xanthohumol, cisplatin, and the combination of cisplatin and xanthohumol inhibited H1299 cells viability. Cisplatin growth inhibitory effects were potentiated by xanthohumol. Xanthohumol induced chromatin condensation and apoptosis and potentiated cisplatin’s effect vs cisplatin alone. Further investigation of growth inhibitory effects, xanthohumol alone induced γH2AX foci formation and the combination potentiated γH2AX foci formation. Cisplatin, xanthohumol at 25 μM, and the combination of cisplatin and xanthohumol at 6.25 and 12.5 μM increased cPARP-1 level. Active caspase-3 was increased by cisplatin, 12.5 μM of xanthohumol, and the combination of xanthohumol and cisplatin. Xanthohumol at 6.25 or 12.5 μM potentiated cisplatin effect on active caspase-3 and cPARP-1, respectively. Xanthohumol at 25 µM significtly induced the expression cell cycle control genes p21WAF1/CIP1 and p14ARF. These results indicate that xanthohumol inhibits proliferation of H1299 cells and induces cell death through cleavage of PARP-1 and activation of caspase-3. The combination of cisplatin and xanthohumol potentiated cytotoxic effects of each other compound. Conclusion: The present study suggests that xanthohumol poses apoptotic effects and potentiates cisplatin’s growth inhibitory effects on metastatic lung cancer cells.

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Environmental and occupational determinants of lung cancer

Cited by 107 publications

References 122 publications

Lung Cancer Management Challenges Amidst COVID-19 Pandemic: Hope Lives Here

Lung Cancer Management Challenges Amidst COVID-19 Pandemic: Hope Lives Here

The Inducible Role of Ambient Particulate Matter in Cancer Progression via Oxidative Stress-Mediated Reactive Oxygen Species Pathways: A Recent Perception

Cytotoxic Effects of Xanthohumol and Its Combination with Cisplatin on Human Metastatic Lung Cancer H1299 Cells

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