Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge

Díaz˗Cruz, M. Silvia; Alda, Miren López de; Barceló, Damià

doi:10.1016/s0165-9936(03)00603-4

Cited by 415 publications

(196 citation statements)

References 42 publications

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“…13 C-phenacetin was used very often in studies where antibiotics were analyzed together with other pharmaceuticals [1,24,27,38,40,41,61]. Although simatone or phenacetin are good ISs, it is desirable that both IS and target compounds should have the structural similarities in order to reflect the properties of the target compound during the entire analytical procedure.…”

Section: Internal Standardmentioning

confidence: 99%

“…Strongly sorbing pharmaceuticals tend to accumulate in soils or sediment (TCs, FQs) and by contrast, highly mobile pharmaceuticals (SAs) have a potential to resist degradation and tend to leach into the groundwater and to be transported with the groundwater, drainage water and surface water run-off to surface waters [12]. The sorptive exchange of chemicals between a water phase and a solid phase is represented by the sorption coefficient K d,solid , which is defined as the ratio between the concentration of the compound in the sorbent and in the water at the equilibrium [13]. Another sorption mechanism is forming complexes between antibiotic and metal ions such as Ca 2+ , Mg 2+ , Fe 3+ or Al 3+ .…”

Section: Introductionmentioning

confidence: 99%

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An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

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a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

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Section: Internal Standardmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

322

170

View full text Add to dashboard Cite

show abstract

“…Some reported antibiotic concentrations in manures reach the level of microgram per kilogram (Haller et al 2002;Hamscher et al 2002;Martínez-Carballo et al 2007;Zhao et al 2010). Thus, application of manures containing antibiotics is the primary route for antibiotics to enter into terrestrial environments (Diaz-Cruz et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

Liu

Ying

et al. 2011

Appl Microbiol Biotechnol

107

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“…The occurrence of pharmaceuticals in the environment is well documented [19], although little is known about their environmental fate and availability [20] or their uptake, possible accumulation, and effects in biota [21]. The determination of the human pharmaceutical propranolol in Baltic Sea blue mussels (Mytilus edulus), exposed to the drug as part of a sublethal chronic exposure experiment, was chosen for an evaluation of the performance of quantitative SALDI analysis.…”

mentioning

confidence: 99%

SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

Amini

Shariatgorji

Thorsén

2009

J. Am. Soc. Mass Spectrom.

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The signal intensity of low-molecular-weight compounds analyzed using surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF-MS) was significantly enhanced when oxidized graphitized carbon black (GCB) particles were used as the desorption/ionization surface. The surface of oxidized GCB contains more carboxylic acid groups than non-oxidized GCB. Carboxylic acid groups enhance the efficiency of the ionization process and the desorption of more hydrophobic compounds. A common pharmaceutical compound, propranolol, was successfully extracted from Baltic Sea blue mussels and quantified using oxidized GCB as the SALDI surface, whereas deuterated propranolol was used as the internal standard. The calibration curve showed a wide linear dynamic range of response (0.1-20 g/mL) and good reproducibility (RSD Ͻ 10%). It was not possible to detect propranolol in Baltic Sea blue mussels when non-oxidized GCB was used as the SALDI surface. (J Am Soc Mass

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Environmental behavior and analysis of veterinary and human drugs in soils, sediments and sludge

Cited by 415 publications

References 42 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Changes in functional diversity of soil microbial community with addition of antibiotics sulfamethoxazole and chlortetracycline

SALDI-MS Signal enhancement using oxidized graphitized carbon black nanoparticles

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