Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling

Taylor, Rulaiha E.; Bhattacharya, Anisha; Guo, Grace L.

doi:10.1124/dmd.121.000388

Drug Metab Dispos

2021

DOI: 10.1124/dmd.121.000388

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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling

Rulaiha E. Taylor

Anisha Bhattacharya

Grace L. Guo

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Cited by 5 publications

(1 citation statement)

References 105 publications

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“…First, there was discussion of sex-dependent effects of AHR agonists in mice on serum and liver bile acids and intestinal mRNA levels for fibroblast growth factor-15 (Choudhuri and Klaassen, 2022). Second, AHR-dependent effects of TCDD and TCDF on multiple aspects of bile acid homeostasis in rats and mice were covered (Taylor et al, 2022). Third, there was consideration of the interactions between nuclear factor erythroidderived 2-like 2 (Nrf2) and AHR in which each xenosensor induces expression of the other (Rockwell et al, 2022).…”

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confidence: 99%

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Riddick

2023

Drug Metab Dispos

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The induction of multiple drug-metabolizing enzymes by halogenated and polycyclic aromatic hydrocarbon toxicants is mediated by the aryl hydrocarbons receptor (AHR). This fascinating receptor also has natural dietary and endogenous ligands, and much is now appreciated about the AHR's developmental and physiological roles, as well as its importance in cancer and other diseases. The past several years has witnessed increasing emphasis on understanding the multifaceted roles of the AHR in the immune system. Most would agree that the "discovery" of the AHR occurred in 1976, with the report of specific binding of a high affinity radioligand in mouse liver, just three years after the launch of the journal Drug Metabolism and Disposition (DMD) in 1973. Over the ensuing fifty years, the AHR and DMD have led parallel and often intersecting lives. The overall goal of this minireview is to provide a decade-by-decade overview of major historical landmark discoveries in the AHR field and to highlight the numerous contributions made by publications appearing in the pages of DMD. It is hoped that this historical tour might inspire current and future research in the AHR field. Significance Statement With the launch of Drug Metabolism and Disposition (DMD) in 1973 and the discovery of the aryl hydrocarbon receptor (AHR) in 1976, the journal and the receptor have led parallel and often intersecting lives over the past fifty years. Tracing the history of the AHR can reveal how knowledge in the field has evolved to the present and highlight the important contributions made by discoveries reported in DMD. This may inspire additional DMD papers reporting future AHR landmark discoveries.

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confidence: 99%

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Riddick

2023

Drug Metab Dispos

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Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Zhang

Liu

et al. 2023

Science of The Total Environment

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Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

Zhang,

Liu,

Sun

et al. 2024

Toxicology

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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling

Cited by 5 publications

References 105 publications

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages ofDrug Metabolism and Disposition

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

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