Environmental contamination status with common ingredients of household and personal care products exhibiting endocrine-disrupting potential

Klančič, Veronika; Gobec, Martina

doi:10.1007/s11356-022-22895-z

Cited by 9 publications

(2 citation statements)

References 182 publications

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“…The genes interacting with at least three of the four xenoestrogens studied were selected to perform functional enrichment analysis using The Database for Annotation, Visualization, and Integrated Discovery (DAVID) (version 2021; david. ncifcrf.gov) [12,13] database. GO function enrichment and KEGG pathway analysis were carried out in David 2021 database by selecting the "Homo sapiens" species.…”

Section: Gene Ontology (Go) Enrichment and Kyoto Encyclopedia Of Gene...mentioning

confidence: 99%

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Warrier,

VG,

R L

et al. 2024

Asian Pac J Cancer Prev

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Background: Breast cancer represents one of the leading causes of death worldwide. Apart from genetic factors, the sex hormone estrogen plays a pivotal role in breast cancer development. We are exposed to a plethora of estrogen mimics on a daily basis via various routes. Nevertheless, how xenoestrogens, the exogenous estrogen mimics, modulate cancer-associated signaling pathways and interact with specific genes is still underexplored. Hence, this study aims to explore the direct or indirect binding partners of xenoestrogens and their expression upon exposure to these estrogenic compounds. Methods: The collection of genes linked to the xenoestrogens Octylphenol, Nonylphenol, Bisphenol-A, and 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane were gathered from the Comparative Toxicogenomics Database. Venny 2.1 was utilized to pinpoint the genes shared by these xenoestrogens. Subsequently, the shared genes underwent Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis using the Database for Annotation, Visualization, and Integrated Discovery bioinformatics resource. A xenoestrogen-protein interaction network was constructed using Search Tool for Interactions of Chemicals. The expressions of common genes were studied with the microarray dataset GSE5200 from the Gene Expression Omnibus database. Also, the expression of a common gene set within different breast cancer subtypes was identified using the University of California, Santa Cruz Xena. Results: The genes linked to xenoestrogens were identified, and 13 genes were found to interact with all four xenoestrogens. Through DAVID analysis, the genes chosen are found to be enriched for various functions and pathways, including pathways in cancer, chemical carcinogenesis-receptor activation, and estrogen signaling pathways. The results of the Comparative Toxicogenomics Database and the chemical-protein interaction network derived from STITCH were similar. Microarray data analysis showed significantly high expression of all 13 genes in another study, with Bisphenol-A and Nonylphenol treated MCF-7 cells, most of the genes are expressed in luminal A or basal breast cancer subtype. Conclusion: In summary, the genes associated with the four xenoestrogens were mostly linked to pathways related to tumorigenesis, and the expression of these genes was found to be higher in breast cancer.

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Section: Gene Ontology (Go) Enrichment and Kyoto Encyclopedia Of Gene...mentioning

confidence: 99%

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Warrier,

VG,

R L

et al. 2024

Asian Pac J Cancer Prev

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“…Parabens enter the body mainly through ingestion, inhalation, and dermal absorption, whereas exposure to alkylphenols usually occurs through drinking water and food [1,4]. Because they readily enter the external environment, such as soil and water, through human activities, humans can also be exposed to them indirectly through secondary exposure [5]. Parabens and alkylphenols are usually metabolized in the liver and excreted in the urine after entering the body [6,7], so studies often use concentrations in urine or blood to understand recent internal human exposure to environmental contaminants.…”

Section: Introductionmentioning

confidence: 99%

Exposure Profile and Characteristics of Parabens and Alkylphenols in Plasma among Rural Adults in Central China

Gao,

Huan,

Song

et al. 2023

Toxics

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Parabens and alkylphenols pose serious hazards to human health, yet there are few studies on their exposure profiles and health risks in rural Chinese populations. In this study, 804 participants were selected from the Henan Rural Cohort in mid-eastern China. The plasma levels of parabens (methylparaben, ethylparaben, propylparaben, butylparaben (BuP)) and alkylphenols (4-tert-butylphenol (4-t-BP), 4-tert-octylphenol (4-t-OP)) were analyzed via liquid chromatography–tandem mass spectrometry. Linear regression models were used to investigate factors that may influence pollutant exposure levels. The correlation between contaminants was assessed using Spearman’s correlation. The human contaminant intake was estimated using the estimated daily intake (EDI). The health risk was assessed using the hazard quotient (HQ). The detection frequency of four parabens and two alkylphenols exceeded 75%, with median concentrations of 0.444, 0.067, 0.078, 0.053, 8.810, and 6.401 ng/mL, respectively. Significant correlations were observed between parabens, as well as between 4-t-BP and 4-t-OP. Regarding gender, paraben concentrations were higher in women than in men, except for BuP. The EDI for pollutants except 4-t-OP was lower than their respective tolerable/acceptable daily intake. In total, 85.70% of participants had 4-t-OP HQ > 1. A widespread exposure to parabens and alkylphenols among the rural population was found. The high health risks of alkylphenol exposure indicate that alkylphenols should be used with caution.

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Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing

Taylor,

Howdeshell,

Bommarito

et al. 2023

Environment International

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Environmental contamination status with common ingredients of household and personal care products exhibiting endocrine-disrupting potential

Cited by 9 publications

References 182 publications

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Xenoestrogen and Its Interaction with Human Genes and Cellular Proteins: An In-Silico Study

Exposure Profile and Characteristics of Parabens and Alkylphenols in Plasma among Rural Adults in Central China

Systematic evidence mapping informs a class-based approach to assessing personal care products and pubertal timing

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