Environmental enrichment aides in functional recovery following unilateral controlled cortical impact of the forelimb sensorimotor area however intranasal administration of nerve growth factor does not

Young, Jennica; Pionk, Timothy; Hiatt, I Mark; Geeck, Katalin; Smith, Jeffrey S.

doi:10.1016/j.brainresbull.2015.04.003

Cited by 21 publications

(11 citation statements)

References 31 publications

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“…The results of present study are not consistent with the findings of some studies that showed NGF reduction by progesterone following brain injury [50] and lack of NGF effect on neuronal recovery following TBI [51]. Possible differences in the results of the present study with others can be due to the difference in the type of brain injuries [50], the dosage and method of progesterone administration, and the severity of neurological injury [51].…”

Section: The Effect Of Progesterone On the Ngf Level In Serum And Csfcontrasting

confidence: 99%

Using the NGF/IL-6 ratio as a reliable criterion to show the beneficial effects of progesterone after experimental diffuse brain injury

Shirazpour

Khaksari

Shahrokhi

et al. 2020

Heliyon

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Acute progesterone injection has been shown to reduce brain edema following traumatic brain injury (TBI) due to its neuroprotective effect. We investigated the effects of sustained release of progesterone through implantation of subcutaneous capsules on rat's brain edema and alteration of cerebrospinal fluid (CSF), and serum ratio of NGF/ IL-6 after TBI. This experiment was performed on ovariectomized (OVX) rats and the brain injury was induced by Marmarou's method. A high and a low dose of progesterone (HP and LP) was injected intraperitoneally two h after the brain injury. In addition, in the capsule progesterone-treated group (CP), the intervention was implemented 6 h after the brain injury. Brain edema, NGF and IL-6 biomarkers in serum and cerebrospinal fluid (CSF) were measured 48 h after the TBI in injection groups and one week after the TBI in the CP group. No significant difference was found in the two groups or in the admonition methods. After TBI, the NGF level increased and IL-6 level decreased by injection of both doses, as well as by taking the capsule. Ratio of NGF/IL-6 in CSF increased significantly by all forms of progesterone administration. The increase in the level of NGF and IL-6 after TBI was higher in CSF than in serum. These results indicated that effects of progesterone in capsule form were better than the injection form. Progesterone probably works by increasing NGF and reducing IL-6. Future studies should investigate the ratio of these biomarkers as a variable to determine the neuroprotective effects of another drug.

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Section: The Effect Of Progesterone On the Ngf Level In Serum And Csfcontrasting

confidence: 99%

Using the NGF/IL-6 ratio as a reliable criterion to show the beneficial effects of progesterone after experimental diffuse brain injury

Shirazpour

Khaksari

Shahrokhi

et al. 2020

Heliyon

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“…Under experimental conditions environmental enrichment refers to housing conditions when complex motor, sensory, and cognitive stimulation is provided compared to a standard environment [30]. Numerous investigations provide evidence that enriched circumstances have protective effects against neural lesions caused by ischemic [57,58,59], toxic [27,60,61], and traumatic injuries [62,63,64]. Several research groups have described that enriched environment has an impact on the severity of symptoms and the progression of Parkinson’s disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Postnatal Enriched Environment in a Model of Parkinson’s Disease in Adult Rats

Jungling

Reglődi

Karadi

et al. 2017

IJMS

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Environmental enrichment is a widespread neuroprotective strategy during development and also in the mature nervous system. Several research groups have described that enriched environment in adult rats has an impact on the progression of Parkinson’s disease (PD). The aim of our present study was to examine the effects of early, postnatal environmental enrichment after 6-hydroxydopamine-induced (6-OHDA) lesion of the substantia nigra in adulthood. Newborn Wistar rats were divided into control and enriched groups according to their environmental conditions. For environmental enrichment, during the first five postnatal weeks animals were placed in larger cages and exposed to intensive complex stimuli. Dopaminergic cell loss, and hypokinetic and asymmetrical signs were evaluated after inducing PD with unilateral injections of 6-OHDA in three-month-old animals. Treatment with 6-OHDA led to a significant cell loss in the substantia nigra of control animals, however, postnatal enriched circumstances could rescue the dopaminergic cells. Although there was no significant difference in the percentage of surviving cells between 6-OHDA-treated control and enriched groups, the slightly less dopaminergic cell loss in the enriched group compared to control animals resulted in less severe hypokinesia. Our investigation is the first to provide evidence for the neuroprotective effect of postnatal enriched environment in PD later in life.

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“…In humans, the high dose of 0.2 mg/kg/day was used in a case report of TBI, cited above (Chiaretti et al, 2017). Based on this evidence and on the duration chosen for the treatment, we decided to use an intermediate dose of NGF (5 µg/kg/day), which was previously described as safe for a 7 day treatment (Young et al, 2015). For the design of the current study, we thoroughly examined the data in the literature to decide how to target tissue reconstruction and functional recovery in our model of brain lesion in rats.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Intranasal Nerve Growth Factor Treatment Favors Neuron Formation in de novo Brain Tissue

Colitti

Desmoulin

Friec

et al. 2022

Front. Cell. Neurosci.

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ObjectiveTo date, no safe and effective pharmacological treatment has been clinically validated for improving post-stroke neurogenesis. Growth factors are good candidates but low safety has limited their application in the clinic. An additional restraint is the delivery route. Intranasal delivery presents many advantages.Materials and MethodsA brain lesion was induced in twenty-four rats. Nerve growth factor (NGF) 5 μg/kg/day or vehicle was given intranasally from day 10 post-lesion for two periods of five weeks, separated by a two-week wash out period with no treatment. Lesion volume and atrophy were identified by magnetic resonance imaging (MRI). Anxiety and sensorimotor recovery were measured by behavior tests. Neurogenesis, angiogenesis and inflammation were evaluated by histology at 12 weeks.ResultsRemarkable neurogenesis occurred and was visible at the second and third months after the insult. Tissue reconstruction was clearly detected by T2 weighted MRI at 8 and 12 weeks post-lesion and confirmed by histology. In the new tissue (8.1% of the lesion in the NGF group vs. 2.4%, in the control group at 12 weeks), NGF significantly increased the percentage of mature neurons (19% vs. 7%). Angiogenesis and inflammation were not different in the two groups. Sensorimotor recovery was neither improved nor hampered by NGF during the first period of treatment, but NGF treatment limited motor recovery in the second period.InterpretationThe first five-week period of treatment was very well tolerated. This study is the first presenting the effects of a long treatment with NGF and has shown an important tissue regeneration rate at 8 and 12 weeks post-injury. NGF may have increased neuronal differentiation and survival and favored neurogenesis and neuron survival through subventricular zone (SVZ) neurogenesis or reprogramming of reactive astrocytes. For the first time, we evidenced a MRI biomarker of neurogenesis and tissue reconstruction with T2 and diffusion weighted imaging.

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Environmental enrichment aides in functional recovery following unilateral controlled cortical impact of the forelimb sensorimotor area however intranasal administration of nerve growth factor does not

Cited by 21 publications

References 31 publications

Using the NGF/IL-6 ratio as a reliable criterion to show the beneficial effects of progesterone after experimental diffuse brain injury

Using the NGF/IL-6 ratio as a reliable criterion to show the beneficial effects of progesterone after experimental diffuse brain injury

Effects of Postnatal Enriched Environment in a Model of Parkinson’s Disease in Adult Rats

Long-Term Intranasal Nerve Growth Factor Treatment Favors Neuron Formation in de novo Brain Tissue

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