Environmental enrichment does not reverse the effects of maternal deprivation on NMDAR and Balb/c mice behaviors

Akıllıoğlu, Kübra; Yılmaz, Mehmet; Boga, Ayper; Binokay, Seçil; Kocatürk-Sel, Sabriye

doi:10.1016/j.brainres.2015.08.009

Cited by 32 publications

(11 citation statements)

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“…Early postnatal NMDAR dysfunction/ablation correlates with decreased numbers of PV+ interneurons, impairment of network synchrony, and cognitive symptoms including working memory loss ( Belforte et al, 2010;Korotkova et al, 2010;Radonjić et al, 2013). As early life stress seems to disturb the physiological glutamate receptor subunits 2B/2A switch (Viviani et al, 2014) and alters NMDAR levels in the hippocampus and cortex (Roceri et al, 2002;Akillioglu et al, 2015;Manatos et al, 2016), we can speculate that NMDAR dysfunction during early postnatal development causes inadequate maturation of PV+ interneurons. In addition, an important event in development occurring between postnatal days 5 and 10 is switch in GABA action from excitatory to inhibitory, due to the switch in ion exchanger composition on the neuron cell membrane (Ben-Ari et al, 2007;Marguet et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus

et al. 2021

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Early life stress has profound effects on the development of the central nervous system. We exposed 9-day-old rat pups to a 24 h maternal deprivation (MD) and sacrificed them as young adults (60-day-old), with the aim to study the effects of early stress on forebrain circuitry. We estimated numbers of various immunohistochemically defined interneuron subpopulations in several neocortical regions and in the hippocampus. MD rats showed reduced numbers of parvalbumin-expressing interneurons in the CA1 region of the hippocampus and in the prefrontal cortex, compared with controls. Numbers of reelin-expressing and calretinin-expressing interneurons were also reduced in the CA1 and CA3 hippocampal areas, but unaltered in the neocortex of MD rats. The number of calbinin-expressing interneurons in the neocortex was similar in the MD rats compared with controls. We analyzed cell death in 15-day-old rats after MD and found no difference compared to control rats. Thus, our results more likely reflect the downregulation of markers than the actual loss of interneurons. To investigate synaptic activity in the hippocampus we immunostained for glutamatergic and inhibitory vesicular transporters. The number of inhibitory synapses was decreased in the CA1 and CA3 regions of the hippocampus in MD rats, with the normal number of excitatory synapses. Our results indicate complex, cell type-specific, and region-specific alterations in the inhibitory circuitry induced by maternal deprivation. Such alterations may underlie symptoms of MD at the behavioral level and possibly contribute to mechanisms by which early life stress causes neuropsychiatric disorders, such as schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus

et al. 2021

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“…Pharmacological blockade of the GluN2B subunit by administration of Ro 25–6981 into the dHIP impaired drug context-induced reinstatement of cocaine-seeking behavior without altering instrumental behavior in the extinction context or food-reinforced instrumental responding (Xie et al, 2013). On the other hand, lack of the effect of the enriched environment on the GluN2B mRNA expression in the HIP was present in mice that underwent ischemic injury after 5 weeks pre-ischemic housing in an enriched environment tested in short- and long-term memory (Gonçalves et al, 2018), as well as in adult mice housed in an enriched environment after maternal deprivation (Akillioglu et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence

et al. 2021

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Background: Cocaine use disorder is associated with compulsive drug-seeking and drug-taking, whereas relapse may be induced by several factors, including stress, drug-related places, people, and cues. Recent observations strongly support the involvement of the N-methyl-D-aspartate (NMDA) receptors in cocaine use disorders and abstinence, whereas withdrawal in different environments may affect the intensification of relapse. Methods: The aim of this study was to examine the GluN2B subunit expression and its association with the postsynaptic density protein 95 (PSD95) in several brain structures in rats with a history of cocaine self-administration and housed either in an enriched environment or in an isolated condition. Furthermore, a selective antagonist of the GluN2B subunit—CP 101,606 (10 and 20 mg/kg) administered during exposure to cocaine or a drug-associated conditional stimulus (a cue) was used to evaluate seeking behavior in rats. Results: In rats previously self-administering cocaine, we observed an increase in the GluN2B expression in the total homogenate from the dorsal hippocampus under both enriched environment and isolation. Cocaine abstinence under isolation conditions increased the GluN2B and GluN2B/PSD95 complex levels in the PSD fraction of the prelimbic cortex in rats previously self-administering cocaine. Administration of CP 101,606 attenuated cue-induced cocaine-seeking behavior only in isolation-housed rats. Conclusion: In summary, in this study we showed region-specific changes in both the expression of GluN2B subunit and NMDA receptor trafficking during cocaine abstinence under different housing conditions. Furthermore, we showed that the pharmacological blockade of the GluN2B subunit may be useful in attenuating cocaine-seeking behavior.

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“…In fact, a study by Luby et al (2012) with children revealed that maternal support positively influenced the development of the hippocampus. Additionally, Akillioglu et al (2015) found that rodents deprived from contact with the progenitor showed changes in the hippocampus as well as impaired spatial memory. In addition, a study accomplished by Karimian and Attari (2015) reported that in a sample of twenty male rats, neurogenesis in the dentate gyrus of the hippocampus was significantly lower in isolated rats when compared to the group of social rats.…”

Section: Discussionmentioning

confidence: 99%

Attachment Dimensions and Spatial Navigation in Female College Students: The Role of Comfort With Closeness and Confidence in Others

et al. 2019

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There is preliminary evidence suggesting that hippocampal functioning is associated with attachment style. However, it is unknown if attachment is also associated with hippocampal-related cognitive function such as spatial learning and recall. This study aims to verify if attachment dimensions are associated with spatial learning and recall. Sixty-five female participants were recruited and were evaluated using the Adult Attachment Scale-R and tested on a virtual maze navigation task (VMT) at one moment (exploratory trial + 3 trials) and 24 h later (3 trials). There was a significant Moment × Trial × Close-Depend interaction for the outcome time, F (2,126) = 3.807, p = 0.025, with post hoc analysis indicating that the High Close-Depend group displayed significant improvements between Trial 1 and Trial 3 in the post-test assessment. Conversely, the Low Close-Depend group displayed significant improvements between Trial 1and Trial 3 but on the pre-test assessment. Furthermore, the Low Close-Depend group presented significant better performance in pre-test Trial 3 in comparison to the High Close-Depend group. Thereby, it seems that low comfort with proximity and trust in others is associated with reduced spatial recall, although spatial learning performance was actually superior in these participants. It is possible that reduced exposure to social interaction and meaningful relationships may be reduced in the Low Close-Depend group, leading to modifications in hippocampal function and, ultimately, reduced spatial recall. Oppositely, participants in the High Close-Depend group may not display typical spatial learning in the proposed task as they are more willing to freely explore the presented environment.

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Environmental enrichment does not reverse the effects of maternal deprivation on NMDAR and Balb/c mice behaviors

Cited by 32 publications

References 50 publications

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus

Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence

Attachment Dimensions and Spatial Navigation in Female College Students: The Role of Comfort With Closeness and Confidence in Others

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