Environmental Epidemiology of Pediatric Asthma and Allergy

Johnson, Christine Cole; Ownby, Dennis R.; Zoratti, Edward M.; Alford, Sharon Hensley; Williams, L. Keoki; Joseph, Christine L.M.

doi:10.1093/epirev/mxf013

Cited by 73 publications

(56 citation statements)

References 208 publications

(190 reference statements)

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“…Concerning socioeconomic status, family sizes are fairly large, and about half of the participants had a low socio-economic status; this may help explain the very low prevalence of asthma, because studies have shown that some socioeconomic and cultural factors are related to a reduced risk of asthma (Johnson et al 2002;Hopkin 1997). The very low prevalence of pet ownership and smoking (1.2% and 3.4%, respectively) among the study group is worth mentioning as these factors provide more reasons for the low prevalence of asthma.…”

Section: Discussionmentioning

confidence: 99%

A preliminary survey of the prevalence of allergic disorders in a questionnaire-based study in Boshroye, a rural area of Iran

et al. 2009

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The susceptibility of 25 Stenotrophomonas maltophilia (S. maltophilia) clinical isolates to four different antimicrobials (trimethoprim/sulfomethoxazole, piperacillin/tazobactam, ceftazidime, ciprofloxacin) were investigated by disk diffusion, E-test and commercial Sensititre and PASCO broth microdilution techniques. Discrepancies between the results of broth microdilution and the other methods studied were characterized as very major, major and minor errors. Using the broth microdilution as the reference method, 24% of the isolates were found susceptible to trimethoprim/ sulfamethoxazole, 24% to ceftazidime, 0% to piperacillin/tazobactam and 12% to ciprofloxacin. Good correlation was observed between the two broth microdilution Sensititre and PASCO for all antibiotics tested. Disc diffusion and E-test generated inconsistent results for all agents except trimethoprim/sulfamethoxazole. A great genomic diversity was demonstrated within the S. maltophilia strains tested. Although our results confirm that trimethoprim-sulfamethoxazole had some in vitro activity against S. maltophilia, further clinical studies are necessary to evaluate the clinical efficacy of these compounds for the treatment of S. maltophilia infections, since no randomized controlled trials have been carried out and no correlation between the clinical response and susceptibility testing results has been reported. Furthermore, the high genomic diversity observed in the S. maltophilia strains indicates the need for careful epidemiological evaluation especially in nosocomial outbreaks.

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Section: Discussionmentioning

confidence: 99%

A preliminary survey of the prevalence of allergic disorders in a questionnaire-based study in Boshroye, a rural area of Iran

et al. 2009

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“…Thus, there is emerging evidence, suggesting, that the etiology of childhood asthma is complex and may include early-life environmental exposures as well as factors related to early allergic sensitization (Johnson, et al, 2002;Muhammad Yu-Fen Bryan, & Frank, n.d.).…”

Section: Literature Reviewmentioning

confidence: 99%

“…In some urban areas, as many as 25% of children have asthma or show signs of wheezing. In fact, it may be greatly under diagnosed (Johnson et al, 2002; Anonymous -1-(n.d.) On the other hand Several European cross-sectional studies have suggested a reduced risk of asthma with early-life exposures to a farming environment (Riedler, et al 2001;.It has been suggested that exposure to a farming environment (e.g. livestock, dust, crop) causes higher levels of bacterial endotoxin exposure, and the latter eventually leads to the production of several cytokines (e.g.interleukin-12, interferon-γ) that tip the balance toward the TH1-over TH2-mediated immunity, thereby reducing asthma risk (Braun, 2001; Muhammad,Yu-Fen Bryan, & Frank, n.d).…”

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Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Kubaisy

Ali

Thamiri

2017

ajE-Bs

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Asthma is one of the most common chronic diseases of children, causing a huge burden on family and society It"s prevalence has risen sharply over the past 30 years in many parts of the world with large geographical variations. However, in Iraq there is no national database which could be obtained. Due to the increasing number of cases and the burden of this health problem we investigated the sociodemographic and other risk factors related to asthma among primary school children. Modified ISAAC questionnaires were completed by the parents of 2262 children randomly chosen. We found males having higher rat of asthma Bing male be more at risk of developing asthma steadily increasing (27.4%), (28.3%)and (39.5%) with increased (CR) crowding rate (<3, 5 -5,and >5) respectively. only CR of >5 acts as a significant risk factor for asthma. Urbanization acts as significant risk for developing asthma EnvironmentBehaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. https://doi.org/10.21834/aje-bs.v2i4.212 Al -Kubaisy, W.,et.al., / Asian Journal of Environmen-Behaviour Studies, ajE-Bs, 2(4) Jul /Sep 2017 (p.75-84) This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for 76 IntroductionChildhood asthma is a major clinical concern worldwide. It causes a huge burden on family and society. It accounts for a large number of lost school days and may deprive the child of both academic achievement and social interaction. Childhood asthma also places strain on healthcare resources as a result of doctor and hospital visits and cost of treatment (Von, 2000). The prevalence of childhood asthma is increasing worldwide, consequently morbidity and mortality and cost of care continue to increase (Partridge& Alwan, 1997;Ece et al, 2001 andRorstad &Bhatt, 2000.)It has been documented that the prevalence of pediatric asthma has risen sharply over the past 30 years in many parts of the world with large geographical variations (Wood, 2002;Yuan, Basso Sorensen & Oslen, 2002;Douwes &Pearce. 2002). The reasons for this dramatic increase are not yet clear and likely to include multiple contributing factors (Wood, 2002; Anonymous-1-, n.d). These variations are possible due to different exposure to respiratory infections, indoor and /or outdoor pollution, and diet (Von, 2000; Partridge&Alwan,1997). Genetics, lifestyle and environmental factors also may play a role in these variations (Ece. et al, 2001).The prevalence of asthma seems to be higher in affluent than non -affluent populations (Partridge& Alwan, 1997; AlDagwood, 2001).No one really knows why more and more children are developing asthma. Some experts suggest that children are being exposed to more and more allergens such as dust, air pollution, and passive smokers. These are factors that trigg...

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“…An accumulating body of evidence indicates that both lifestyle factors and environmental exposures during early life may play particularly important roles in asthma occurrence (Johnson et al 2002). Moreover, timing of such environmental exposures during early development may also be critically important in allergic sensitization and later asthma development.…”

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confidence: 99%

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

Salam

Langholz

et al. 2004

Environ Health Perspect

181

107

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Early-life experiences and environmental exposures have been associated with childhood asthma. To investigate further whether the timing of such experiences and exposures is associated with the occurrence of asthma by 5 years of age, we conducted a prevalence case-control study nested within the Children's Health Study, a population-based study of > 4,000 school-aged children in 12 southern California communities. Cases were defined as physician-diagnosed asthma by age 5, and controls were asthma-free at study entry, frequency-matched on age, sex, and community of residence and countermatched on in utero exposure to maternal smoking. Telephone interviews were conducted with mothers to collect additional exposure and asthma histories. Conditional logistic regression models were fitted to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Asthma diagnosis before 5 years of age was associated with exposures in the first year of life to wood or oil smoke, soot, or exhaust (

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Environmental Epidemiology of Pediatric Asthma and Allergy

Cited by 73 publications

References 208 publications

A preliminary survey of the prevalence of allergic disorders in a questionnaire-based study in Boshroye, a rural area of Iran

A preliminary survey of the prevalence of allergic disorders in a questionnaire-based study in Boshroye, a rural area of Iran

Pediatric Asthma and its Relation to SocioDemographic Factors in Baghdad

Early-life environmental risk factors for asthma: findings from the Children's Health Study.

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