Environmental epigenetics and allergic diseases: recent advances

Kuriakose, Julie; Miller, Rachel L.

doi:10.1111/j.1365-2222.2010.03599.x

Cited by 51 publications

(31 citation statements)

References 81 publications

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“…A more complete understanding of the control of developmental processes that occur during early-life maturation of the T-cell compartment may yield insights relevant to a range of autoimmune and allergic disorders. 26,27 Integration of DNA methylation and gene expression data on a genome-wide scale revealed that a direct relationship between DNA methylation and gene expression is often difficult to infer. Indeed, only a subset of probes on the methylation array Epigenetic programming of CD4 þ T-cell phenotypes during early life D Martino et al correlated with gene expression measurements in the expected direction based on the current dogma of DNA methylation being largely inhibitory to gene expression.…”

Section: Discussionmentioning

confidence: 99%

Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans

et al. 2012

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The aim of this study was to investigate the dynamics and relationship between DNA methylation and gene expression during early T-cell development. Mononuclear cells were collected at birth and at 12 months from 60 infants and were either activated with anti-CD3 for 24 h or cultured in media alone, and the CD4 þ T-cell subset purified. DNA and RNA were co-harvested and DNA methylation was measured in 450 000 CpG sites in parallel with expression measurements taken from 25 000 genes. In unstimulated cells, we found that a subset of 1188 differentially methylated loci were associated with a change in expression in 599 genes (adjusted P valueo0.01, b-fold 40.1). These genes were enriched in reprogramming regions of the genome known to control pluripotency. In contrast, over 630 genes were induced following low-level T-cell activation, but this was not associated with any significant change in DNA methylation. We conclude that DNA methylation is dynamic during early T-cell development, and has a role in the consolidation of T-cell-specific gene expression. During the early phase of clonal expansion, DNA methylation is stable and therefore appears to be of limited importance in short-term T-cell responsiveness.

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Section: Discussionmentioning

confidence: 99%

Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans

et al. 2012

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“…Exposure to diesel exhaust particles, cigarette smoke and ozone has been reported to cause epigenetic changes in the respiratory tract, which have been implicated in the development of inflammatory lung diseases (Rajendrasozhan et al, 2008; Baccarelli et al, 2009; Ho et al, 2012). DNA methylation and histone modifications are thought to be the major epigenetic mechanisms leading to transcriptional silencing of genes relevant to the development of airway inflammatory and allergic diseases following environmental exposures (Adcock et al, 2007; Kuriakose and Miller, 2010; Ho et al, 2012; Lepeule et al, 2012; Tzouvelekis and Kaminski, 2015). …”

Section: Introductionmentioning

confidence: 99%

World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung

Sunil

Vayas

Fang

et al. 2017

Experimental and Molecular Pathology

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Exposure to World Trade Center (WTC) dust has been linked to respiratory disease in humans. In the present studies we developed a rodent model of WTC dust exposure to analyze lung oxidative stress and inflammation, with the goal of elucidating potential epigenetic mechanisms underlying these responses. Exposure of mice to WTC dust (20 μg, i.t.) was associated with upregulation of heme oxygenase-1 and cyclooxygenase-2 within 3 days, a response which persisted for at least 21 days. Whereas matrix metalloproteinase was upregulated 7 days post-WTC dust exposure, IL-6RA1 was increased at 21 days; conversely, expression of mannose receptor, a scavenger receptor important in particle clearance, decreased. After WTC dust exposure, increases in methylation of histone H3 lysine K4 at 3 days, lysine K27 at 7 days and lysine K36, were observed in the lung, along with hypermethylation of Line-1 element at 21 days. Alterations in pulmonary mechanics were also observed following WTC dust exposure. Thus, 3 days post-exposure, lung resistance and tissue damping were decreased. In contrast at 21 days, lung resistance, central airway resistance, tissue damping and tissue elastance were increased. These data demonstrate that WTC dust-induced inflammation and oxidative stress are associated with epigenetic modifications in the lung and altered pulmonary mechanics. These changes may contribute to the development of WTC dust pathologies.

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“…It is possible that the increase in the prevalence of allergic diseases, including AR, is associated with complex gene-environment interactions. Previous studies have shown that environmental factors contribute to the growing epidemic of allergies worldwide, which are accompanied by epigenetic changes in some cases [3]. …”

Section: Introductionmentioning

confidence: 99%

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Rui

et al. 2019

Int Arch Allergy Immunol

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Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). Methods: In total, 234 patients, aged 6 years, were recruited, i.e., 114 were patients with AR (AR group) and 120 healthy children without AR (NAR group). The DNA methylation patterns of the IFN-γ promoter regions in CD4+ cells were analyzed using bisulfite sequencing. The percentage of Th1 was investigated by flow cytometry. The relationship among DNA methylation, early-life environment, and AR was examined. Results: After adjusting for several likely confounders, there was a higher likelihood of AR in children who had mothers with allergies than in children who had nonallergic mothers (OR = 5.19; 95% CI 1.18–29.41), in children who were born in autumn or winter than in children who were born in the summer or spring (OR = 2.69; 95% CI 1.34–5.40), and in children who lived with indoor carpet or wallpaper than in children who lived without indoor carpet or wallpaper (OR = 4.14; 95% CI 2.05–8.30). Compared to the NAR group, the AR group had higher mean methylation levels of the promoter region in IFN-γY, and lower numbers of IFN-γ+CD4+ cells were associated with autumn-winter birthdates. The season of birth had an indirect effect on AR at 6 years, which was mediated by the mean IFN-γ promoter methylation level. Conclusions: This study suggests that early-life environments affect AR, and this is supported by the finding of IFN-γY methylation as a mediator of the effect of an individual’s season of birth on AR.

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Environmental epigenetics and allergic diseases: recent advances

Cited by 51 publications

References 81 publications

Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans

Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans

World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

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