Environmental exposition to xenoestrogens (XEs) and related health effects

Nowak-Starz, Grażyna; Łuszczki, Jarogniew J.; Chmielewski, Jarosław; Gworek, Barbara; Czarny-Działak, Małgorzata; Dutkiewicz, Ewa; Król, Halina

doi:10.5601/jelem.2021.26.2.2157

Cited by 3 publications

(4 citation statements)

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“…Intrauterine exposure to these EDs especially during the early developmental phases has several negative impacts including the increasing rates of RPL 2 , 3 , 8 . Most of the OCPs’ bad effects come from the disruption of the signaling cascades for many hormones such as thyroid, HCG, and sex steroids 6 , 7 , 10 , 24 , 29 , 30 . Also, they impair the body’s antioxidant capacity and generate OS and thus are genotoxic 31 .…”

Section: Discussionmentioning

confidence: 99%

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RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

El-Baz

Amin

Mohany

2023

Sci Rep

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We investigated the plasma levels of pesticides components namely polychlorinated biphenyls (PCBs), dieldrin, dichlorodiphenyldichloroethylene (DDE), ethion, malathion, and chlorpyrifos in recurrent pregnancy loss (RPL) cases, and tested their associations with placental oxidative stress (OS) biomarkers [nitric oxide (NO.), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), and superoxide dismutase (SOD)] and with placental apoptotic/antiapoptotic indices (Bcl-2 and caspase-3), and evaluated their possible cut-off points to distinguish RPL cases. The study recruited 101 pregnant women divided into; G1 [n = 49, control, normal 1st-trimester pregnancy, normal obstetric history with at least one previous normal live birth], G2 [n = 26, cases with missed abortion (< 3 abortions) before 24 weeks of gestation], and G3 [n = 26, cases with missed abortion (≥ 3 abortions) before 24 weeks of gestation]. The plasma pesticide levels were analyzed by gas chromatography-mass spectrometry. Plasma human chorionic gonadotrophin (HCG), placental OS, Bcl-2, and caspase-3, were analyzed by their corresponding methods and kits. Plasma PCBs, DDE, dieldrin, and ethion levels were significantly higher in RPL cases than in normal pregnancies (p ≤ 0.001). These levels correlated positively with placental OS and apoptosis and negatively with plasma HCG levels. Also, these levels were reliable markers of risk to RPL. Malathion and chlorpyrifos were not detected in any of the study’s participants. Pesticides may be risk factors in cases of spontaneous RPL cases. They are associated with an increasing placental OS and placental apoptosis. Specific measures should be taken to decrease maternal exposure to these pollutants’ sources, especially in underdeveloped and developing countries.

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Section: Discussionmentioning

confidence: 99%

“…Many of the pesticides’ components (e.g., PCBs) are xenoestrogens that disrupt the action of the endogenous estrogens and negatively impact human health. These impacts are more dangerous when exposure occurs early in intrauterine life 29 .…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

El-Baz

Amin

Mohany

2023

Sci Rep

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“…Lead (Pb) is one of the principal heavy metal contaminants. Lead exposure contributes to metabolic disorders in various tissues encompassing the liver, kidneys, gonads, blood and the central nervous system of mammals, which are associated with respiratory, neurologic, hematological, gastrointestinal, cardiovascular, genitourinary, circulatory and immunological pathologies in mammals including humans (6)(7)(8). Lead is regarded as a highly poisonous environmental pollutant.…”

Section: Introductionmentioning

confidence: 99%

A novel mushroom (Auricularia polytricha) glycoprotein protects against lead-induced hepatoxicity, promotes lead adsorption, inhibits organ accumulation of lead, upregulates detoxifying proteins, and enhances immunoregulation in rats

Zhao

Gao²,

Wang

et al. 2023

Front. Nutr.

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IntroductionLead is a ubiquitous environmental and industrial pollutant. Its nonbiodegradable toxicity induces a plethora of human diseases. A novel bioactive glycoprotein containing 1.15% carbohydrate, with the ability of adsorbing lead and effecting detoxification, has been purified from Auricularia polytricha and designated as APL. Besides, its mechanisms related to regulation of hepatic metabolic derangements at the proteome level were analyzed in this study.MethodsChromatographic techniques were utilized to purify APL in the current study. For investigating the protective effects of APL, Sprague-Dawley rats were given daily intraperitoneal injections of lead acetate for establishment of an animal model, and different dosages of APL were gastrically irrigated for study of protection from lead detoxification. Liver samples were prepared for proteomic analyses to explore the detoxification mechanisms.Results and discussionThe detoxifying glycoprotein APL displayed unique molecular properties with molecular weight of 252-kDa, was isolated from fruiting bodies of the edible fungus A. polytricha. The serum concentrations of lead and the liver function biomarkers aspartate and alanine aminotransferases were significantly (p<0.05) improved after APL treatment, as well as following treatment with the positive control EDTA (300 mg/kg body weight). Likewise, results on lead residue showed that the clearance ratios of the liver and kidneys were respectively 44.5% and 18.1% at the dosage of APL 160 mg/kg, which was even better than the corresponding data for EDTA. Proteomics disclosed that 351 proteins were differentially expressed following lead exposure and the expression levels of 41 proteins enriched in pathways mainly involved in cell detoxification and immune regulation were normalized after treatment with APL-H. The results signify that APL ameliorates lead-induced hepatic injury by positive regulation of immune processing, and suggest that APL can be applied as a therapeutic intervention of lead poisoning in clinical practice. This report represents the first demonstration of the protective action of a novel mushroom protein on lead-elicited hepatic toxicity.

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“…In this review, we will consider the broader definition of xenoestrogens that includes heavy metals [ 27 , 28 , 29 ]. Xenoestrogens influence on animal physiology is in most cases observed as having negative effects [ 30 , 31 , 32 , 33 ] ( Figure 1 ). However, some of those compounds may positively affect the organism, such as anti-tumor activity of certain phytoestrogens in estrogen-dependent breast tumors [ 34 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

Wojnarowski

Cholewińska

Palić

et al. 2022

IJMS

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Estrogen receptors (ERs) play a key role in many biochemical and physiological processes, that are involved in maintaining organism homeostasis. At the most basic level, they can be divided into nuclear estrogen receptors and membrane estrogen receptors that imply their effect in two ways: slower genomic, and faster non-genomic. In these ways, estrogens and xenoestrogens can negatively affect animal health and welfare. Most of the available literature focuses on human and mammalian physiology, and clearly, we can observe a need for further research focusing on complex mutual interactions between different estrogens and xenoestrogens in aquatic animals, primarily fishes. Understanding the mechanisms of action of estrogenic compounds on the ERs in fishes and their negative consequences, may improve efforts in environmental protection of these animals and their environment and benefit society in return. In this review, we have summarized the ER-mediated effects of xenoestrogens and estrogens on teleost fishes metabolism, their carcinogenic potential, immune, circulatory, and reproductive systems.

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Environmental exposition to xenoestrogens (XEs) and related health effects

Cited by 3 publications

References 0 publications

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

RETRACTED ARTICLE: Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case–control study

A novel mushroom (Auricularia polytricha) glycoprotein protects against lead-induced hepatoxicity, promotes lead adsorption, inhibits organ accumulation of lead, upregulates detoxifying proteins, and enhances immunoregulation in rats

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes—Review

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