Environmental exposure to asbestos

Bayram, Mehmet; Bakan, Nur Dilek

doi:10.1097/mcp.0000000000000053

Cited by 24 publications

(5 citation statements)

References 35 publications

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“…Various investigators reported that this uncertainty is based upon the possibility that not all forms of asbestos drive an autoimmune response, and that autoimmune responses are seen more often with amphibole, rather than chrysotile, exposures (Ferro, et al 2013;Pfau, et al 2015;Pfau 2017). Historically, chrysotile exposures have been prevalent due to extensive commercial use, but reductions in asbestos mining and product manufacturing are revealing that environmental asbestos exposures are abundant, often contain amphibole fibers, and exert adverse health impacts even at low levels of exposure (Baumann et al 2013;Wolfe, et al 2017;Bayram and Bakan 2014, Buck, et al 2013, Lockey, et al 2015, Andujar et al, 2016Lemen, 2016;Szeinuk, et al 2017). Therefore, the current study regarding LAA suggests that more research is needed regarding specific mineral fibers that may be triggers for SAID.…”

Section: Introductionmentioning

confidence: 93%

Case series: rheumatological manifestations attributed to exposure to Libby Asbestiform Amphiboles

Diegel

Black

Pfau

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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An increased risk for Systemic Autoimmune Diseases (SAID) has been reported in Libby, Montana, where extensive exposures to fibrous amphiboles occurred due to mining and use of asbestos-laden vermiculite. In addition, positive antinuclear autoantibody tests are associated with exposure to Libby Asbestiform Amphiboles (LAA) in both humans and mice. Among 6603 subjects who underwent health screening at the Center for Asbestos Related Diseases (CARD, Libby MT), 13.8% were diagnosed with an autoimmune disease, with prevalence values for the most common SAID being significantly higher than expected in the United States. Among the CARD screening population, serological and clinical profiles are diverse, representing symptoms and autoantibodies reflective of systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis and other rheumatic syndromes including Undifferentiated Connective Tissue Disease (UCTD). Based upon screening of medical records by physicians with rheumatology expertise, the evolving nature of rheumatological disease in these patients is often atypical, with mixed diagnostic criteria and with a 1:1 male-to-female ratio. Through the Libby Epidemiology Research Program, cases were identified that illustrate clinical autoimmune outcomes with LAA exposure. Our goal was to better characterize SAID in Libby, MT in order to improve recognition of autoimmune outcomes associated with this exposure. In view of recent discoveries of widespread exposure to fibrous minerals in several areas of the U.S. and globally, it is critical to evaluate rheumatologic manifestations in other cohorts so that screening, surveillance and diagnostic procedures are able to detect and recognize potential autoimmune outcomes of asbestos exposure.

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Section: Introductionmentioning

confidence: 93%

Case series: rheumatological manifestations attributed to exposure to Libby Asbestiform Amphiboles

Diegel

Black

Pfau

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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“…In urban areas and in the Colombian Andean and Caribbean regions, the highest frequency among people attended by asbestosis were estimated in the two five-year periods and analyzed. Likewise, in these geopolitical regions are the cities with the highest demographic and industrial growth—factors that stimulated internal migration to main cities and influenced the level of urbanization [ 24 25 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Asbestosis between 2010–2014 and 2015–2019 Periods in Colombia: Descriptive Study

Camero,

Villamizar,

Pombo

et al. 2023

Annals of Global Health

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Background: Asbestosis is a prevalent worldwide problem, but scarce data sourced from developing countries are available. We describe the sociodemographic characteristics and patterns in the occurrence of care provided for asbestosis in Colombia during the periods 2010–2014 and 2015–2019 to establish the behavior, trends, and variables associated with concentrations among people attended by asbestosis. Methods: A retrospective descriptive study was carried out with data from the Integrated Social Protection Information System (SISPRO) for two 5-year periods. People attended by asbestosis (ICD-10: J61) were identified; the frequency of patient visits, sociodemographic characteristics, case distribution patterns, and trends in both five-year periods were described, as was the crude frequency (cFr, 95% CI) of asbestosis (1,000,000 people/year) in both five-year periods (cFr ratio, 95% CI). Results: During the period 2010–2019, 765 people attended by asbestosis were identified; there were 308 people attended by asbestosis between 2010–2014 (cFr: 2.20, 1.96–2.47), and ther were 457 people attended by asbestos between 2015–2019 (cFr: 3.14, 2.92–3.50). In both periods, the estimated cFr in men was nine times the estimated cFr in women. The cFr increased in the 2015–2019 period (cFr_ratio: 1.23, 1.06–1.43). Compared with the 2010–2014 period, the cFr of asbestosis increased in women (cFr_ratio: 1.44, 1.03–2.01), in the Andean (cFr_ratio: 1.61, 1.35–1.95) and Caribbean regions (cFr_ratio: 1. 66, 1.21–2.30), in the urban area (cFr_ratio: 1.24, 1.05–1.48), and in the age groups 45–59 years (cFr_ratio: 1.34, 1.001–1.79) and ≥60 years (cFr_ratio: 1.43, 1.13–1.83). Discussion: During two five-year periods, the cFr of asbestosis was higher in men; between the first and second five-year periods, it increased significantly, especially in urbanized geographic areas and in populations aged ≥45 years. The estimates possibly reflect the effect of disease latency or the expected impact of public health policies to monitor asbestos exposure and complications.

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“…The association between asbestos and lung cancer is still debated, 10 given the typically multi-factorial etiology of this cancer, whereas the causal relationship between asbestos exposure and mesothelioma is much more specific. 11 …”

Section: Discussionmentioning

confidence: 99%

Elemental analysis of histological specimens: a method to unmask nano asbestos fibers

et al. 2016

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There is an increasing amount of evidence that nanoparticles may enhance toxicological potential in comparison to the same material in the bulk form. The aim of this study was to develop a new method to unmask asbestos nanofibers from Formalin-Fixed Paraffin-Embedded (FFPE) tissue. For the first time, in this study we applied Energy Dispersive X-ray (EDX) microanalysis through transmission electron microscopy to demonstrate the presence of asbestos nanofibers in histological specimens of patients with possible occupational exposure to asbestos. The diagnostic protocol was applied to 10 randomly selected lung cancer patients with no history of previous asbestos exposure. We detected asbestos nanofibers in close contact with lung cancer cells in two lung cancer patients with previous possible occupational exposure to asbestos. We were also able to identify the specific asbestos iso-type, which in one of the cases was the same rare variety used in the workplace of the affected patient. By contrast, asbestos nanofibers were not detected in lung cancer patients with no history of occupational asbestos exposure.The proposed technique can represent a potential useful tool for linking the disease to previous workplace exposure in uncertain cases. Furthermore, Formalin-Fixed Paraffin-Embedded (FFPE) tissues stored in the pathology departments might be re-evaluated for possible etiological attribution to asbestos in the case of plausible exposure. Since diseases acquired through occupational exposure to asbestos are generally covered by workers’ insurance in most countries, the application of the protocol used in this study may have also relevant social and economic implications.

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Environmental exposure to asbestos

Abstract: Although there is an expectance of decline in ARDs caused by industrial exposure to asbestos, the environmental exposure to asbestos is still a challenge waiting to be overcome.

Cited by 24 publications

References 35 publications

Case series: rheumatological manifestations attributed to exposure to Libby Asbestiform Amphiboles

Case series: rheumatological manifestations attributed to exposure to Libby Asbestiform Amphiboles

Epidemiology of Asbestosis between 2010–2014 and 2015–2019 Periods in Colombia: Descriptive Study

Elemental analysis of histological specimens: a method to unmask nano asbestos fibers

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