Environmental exposures and puberty in inner-city girls

Wolff, Mary S.; Britton, Julie A.; Boguski, Lisa; Hochman, Sarah; Maloney, Nell; Serra, Nicole; Liu, Zhisong; Berkowitz, Gertrud S.; Larson, Signe; Forman, Joel

doi:10.1016/j.envres.2008.03.006

Cited by 155 publications

(121 citation statements)

References 66 publications

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“…5B), we have proposed the involvement of DDT in the early pathogenesis of that increased rate of sexual precocity (Krstevska-Konstantinova et al, 2001). Wolff et al (2008) do not find any change in timing of breast development in relation to serum DDE levels in girls in New York city (Table 5). Data on the timing of menarche (Table 6) after prepubertal exposure to DDE (DDT) are discrepant since it has been found to be early (Ouyang et al, 2005;Deng et al, 2012) or normal (Denham et al, 2005;Ozen et al, 2012).…”

Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 98%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

161

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 98%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

161

140

View full text Add to dashboard Cite

show abstract

“…An explanation of the relationship between SES and gonadal function in females and males could be that there are nutritional and environmental differences due to SES. Endocrine disrupters have been shown to affect pubertal development, and subjects with a lower SES might be more exposed to endocrine disrupters, for example by inadequate food consumption (31,32).…”

Section: Discussionmentioning

confidence: 99%

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Kerkhof

Leunissen

Willemsen

et al. 2010

European Journal of Endocrinology

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Background/objectives: Preterm birth has been associated with reduced reproduction rates, and controversies remain regarding the effect of being born small for gestational age (SGA) on ovarian function. Recent findings in young men showed no effect of preterm and SGA birth on testis function. We hypothesised that follicle pool size in young adult women is also not affected by preterm and SGA birth. Design/methods: In 279 young women of the PROGRAM/PREMS study, aged 18-24 years, the influence of gestational age, birth length and birth weight on serum levels of anti-Mü llerian hormone (AMH) was analysed with multiple regression modelling. Additionally, AMH levels were analysed in preterm-versus term-born females and in three subgroups: females born SGA with either short stature or catch-up growth (SGA-CU), and females born term and appropriate for gestational age with normal stature (AGA controls). Results: Preterm and SGA birth did not affect AMH and other hormone levels. Older age at menarche and oral contraceptive pill use (OC-use) were related to lower AMH levels, and maternal smoking during gestation was related to higher AMH levels. After correction for maternal smoking, lower socioeconomic status (SES) was associated with lower AMH levels. In subgroup comparisons, SGA-CU women showed higher AMH levels than AGA controls, also after adjustment for several factors. Conclusion: Preterm and SGA birth did not affect AMH levels. Factors associated with serum AMH levels were OC-use, age at menarche, maternal smoking during gestation and SES. We conclude that preterm-and/or SGA-born females are not likely to have a reduced follicle pool size.

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“…Values less than the detection limit were set to the lowest positive value for a given analyte. This decision was based on the fact that many chemists and statisticians believe that a reported result, even if it is below the ''criterion for detection,'' is the best available estimate of the true value, and is preferable to assigning a zero or an arbitrary constant, such as one-half the detection limit (Wolff et al, 2008;Fitzgerald et al, 2007b). Coefficients of variation (SD/mean) of DDE and PCBs from the fortified pools were 10% to 15%.…”

Section: Serum Pcb Analysismentioning

confidence: 99%

Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval

Seegal

Fitzgerald

Hills

et al. 2010

J Expo Sci Environ Epidemiol

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To date, most estimates of the half-life of polychlorinated biphenyls (PCBs) in humans have been based on relatively short follow-up periods. To address this issue, we determined the half-lives of PCB congeners of occupational origin in the serum of former capacitor workers as part of a study conducted in [2003][2004][2005][2006] F approximately 28 years after their last occupational exposure. A total of 241 persons from a source population of 6798 former capacitor workers were interviewed and asked to donate a blood sample for serum PCB congener analysis. A subgroup of 45 participants also had serum archived from 1976 and reanalyzed for the same 27 PCB congeners by the same laboratory. Our estimates of the half-lives of the congeners among these 45 persons were longer than those reported by Wolff et al. (1992), due primarily to the much longer interval between exposure and determination of serum PCB concentrations. Half-lives were significantly greater for the heavy versus light occupational congeners, for women versus men and for those with low versus high initial exposure. Current serum total PCB concentrations, expressed as the geometric mean of wet weight data, averaged 6.7 ng/g for the entire 241-person cohort, which represents a 10-fold decrease from values reported in the late 1970s, but is still nearly twice the average for persons of similar age residing in the same area, but without occupational exposure. In addition, current serum PCB concentrations remained significantly and positively associated with earlier occupational exposure, but were not associated with fresh water fish consumption. In general, the results support a consistent and long-duration trend of increased PCB body burden in this cohort of former capacitor workers compared with non-occupationally exposed individuals. The results may aid in further understanding the toxicological/epidemiological consequences of exposure to PCBs in humans.

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Environmental exposures and puberty in inner-city girls

Cited by 155 publications

References 66 publications

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women

Estimating the half-lives of PCB congeners in former capacitor workers measured over a 28-year interval

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