Environmental Exposures may Hold the Key; Impact of Air Pollution, Greenness, and Rural/Farm Lifestyle on Allergic Outcomes

Jackson, Courtney M.; Kaplan, Alexandra N; Järvinen, Kirsi M.

doi:10.1007/s11882-022-01061-y

Cited by 7 publications

(2 citation statements)

References 130 publications

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“…Several components of the exposome are proposed to contribute to the rise in food allergy, including environmental exposure to food allergens through non-oral routes and exposure to pollutants. [58][59][60] Despite their potential adjuvant effects, [61][62][63][64] the role of air pollutants in food allergy development is unclear, with cohort studies and meta-analyses showing conflicting findings regarding associations between air pollution exposure and food allergy development. 58 A possible explanation is that food sensitization involves co-exposure to air pollutants and environmental food allergens through nonoral routes.…”

Section: Discussionmentioning

confidence: 99%

“…The recent increase in food allergy prevalence suggests that environmental exposures contribute to food allergy development. Several components of the exposome are proposed to contribute to the rise in food allergy, including environmental exposure to food allergens through non‐oral routes and exposure to pollutants 58–60 . Despite their potential adjuvant effects, 61–64 the role of air pollutants in food allergy development is unclear, with cohort studies and meta‐analyses showing conflicting findings regarding associations between air pollution exposure and food allergy development 58 .…”

Section: Discussionmentioning

confidence: 99%

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Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model

Immormino,

Smeekens,

Mathai

et al. 2023

Allergy

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BackgroundEnvironmental exposure to peanut through non‐oral routes is a risk factor for peanut allergy. Early‐life exposure to air pollutants, including particulate matter (PM), is associated with sensitization to foods through unknown mechanisms. We investigated whether PM promotes sensitization to environmental peanut and the development of peanut allergy in a mouse model.MethodsC57BL/6J mice were co‐exposed to peanut and either urban particulate matter (UPM) or diesel exhaust particles (DEP) via the airways and assessed for peanut sensitization and development of anaphylaxis following peanut challenge. Peanut‐specific CD4+ T helper (Th) cell responses were characterized by flow cytometry and Th cytokine production. Mice lacking select innate immune signaling genes were used to study mechanisms of PM‐induced peanut allergy.ResultsAirway co‐exposure to peanut and either UPM‐ or DEP‐induced systemic sensitization to peanut and anaphylaxis following peanut challenge. Exposure to UPM or DEP triggered activation and migration of lung dendritic cells to draining lymph nodes and induction of peanut‐specific CD4+ Th cells. UPM‐ and DEP‐induced distinct Th responses, but both stimulated expansion of T follicular helper (Tfh) cells essential for peanut allergy development. MyD88 signaling was critical for UPM‐ and DEP‐induced peanut allergy, whereas TLR4 signaling was dispensable. DEP‐induced peanut allergy and Tfh‐cell differentiation depended on IL‐1 but not IL‐33 signaling, whereas neither cytokine alone was necessary for UPM‐mediated sensitization.ConclusionEnvironmental co‐exposure to peanut and PM induces peanut‐specific Tfh cells and peanut allergy in mice.

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